Early Rise of Blood T Follicular Helper Cell Subsets and Baseline Immunity as Predictors of Persisting Late Functional Antibody Responses to Vaccination in Humans.

Early Rise of Blood T Follicular Helper Cell Subsets and Baseline Immunity as Predictors of Persisting Late Functional Antibody Responses to Vaccination in Humans.

CD4+ T follicular helper cells (T(FH)) have been identified as the T-cell subset specialized in providing help to B cells for optimal activation and production of high affinity antibody. We recently demonstrated that the expansion of peripheral blood influenza-specific CD4(+)IL-21(+)ICOS1(+) T helpe...

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Bibliographic Details
Main Authors: Fabiana Spensieri, Emilio Siena, Erica Borgogni, Luisanna Zedda, Rocco Cantisani, Nico Chiappini, Francesca Schiavetti, Domenico Rosa, Flora Castellino, Emanuele Montomoli, Caroline L Bodinham, David J Lewis, Duccio Medini, Sylvie Bertholet, Giuseppe Del Giudice
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4918887?pdf=render

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