Serum ferritin levels and polycystic ovary syndrome in obese and nonobese women
Objective: The aim of this study is to evaluate serum ferritin levels and polycystic ovary syndrome (PCOS)-related complications in obese and nonobese women. Materials and methods: This retrospective study included 539 (286 with PCOS and 253 without PCOS). Results: Serum ferritin correlated with men...
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doaj-df22d0ac26124e4cb31021f6640d88e72020-11-25T00:17:56ZengElsevierTaiwanese Journal of Obstetrics & Gynecology1028-45592015-08-0154440340710.1016/j.tjog.2014.06.005Serum ferritin levels and polycystic ovary syndrome in obese and nonobese womenPo-Chun Ko0Shih-Yi Huang1Ching-Hung Hsieh2Ming-I Hsu3Chun-Sen Hsu4Department of Obstetrics and Gynaecology, Wan Fang Hospital, Taipei Medical University, Taipei, TaiwanSchool of Nutrition and Health Sciences, College of Public Health and Nutrition, Taipei Medical University, Taipei, TaiwanDepartment of Obstetrics and Gynecology, Clinic of Fu Jen Catholic University, Taipei, TaiwanDepartment of Obstetrics and Gynaecology, Wan Fang Hospital, Taipei Medical University, Taipei, TaiwanDepartment of Obstetrics and Gynaecology, Wan Fang Hospital, Taipei Medical University, Taipei, TaiwanObjective: The aim of this study is to evaluate serum ferritin levels and polycystic ovary syndrome (PCOS)-related complications in obese and nonobese women. Materials and methods: This retrospective study included 539 (286 with PCOS and 253 without PCOS). Results: Serum ferritin correlated with menstrual cycle length, sex hormone-binding globulin, total testosterone, androstenedione, triglyceride, and total cholesterol in both obese and nonobese women. Obese women with high ferritin levels exhibited higher insulin resistance, impaired glucose tolerance, and liver enzymes (glutamic oxaloacetic transaminase, glutamic pyruvic transaminase) than obese women with low ferritin levels. However, among nonobese women, insulin resistance and risk of diabetes were not significantly different between the high and low ferritin groups. Independent of obesity, hypertriglyceridemia was the major metabolic disturbance observed in women with elevated serum ferritin levels. Conclusion: Elevated serum ferritin levels are associated with increased insulin resistance and risk of diabetes in obese women but not in nonobese women. However, higher serum ferritin levels were correlated with a greater risk of hyperglyceridemia in both obese and nonobese women. Therefore, hypertriglyceridemia in women with PCOS might be associated with iron metabolism.http://www.sciencedirect.com/science/article/pii/S1028455915001060ferritininsulin resistancemetabolic syndromeobesitypolycystic ovary syndrome |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Po-Chun Ko Shih-Yi Huang Ching-Hung Hsieh Ming-I Hsu Chun-Sen Hsu |
spellingShingle |
Po-Chun Ko Shih-Yi Huang Ching-Hung Hsieh Ming-I Hsu Chun-Sen Hsu Serum ferritin levels and polycystic ovary syndrome in obese and nonobese women Taiwanese Journal of Obstetrics & Gynecology ferritin insulin resistance metabolic syndrome obesity polycystic ovary syndrome |
author_facet |
Po-Chun Ko Shih-Yi Huang Ching-Hung Hsieh Ming-I Hsu Chun-Sen Hsu |
author_sort |
Po-Chun Ko |
title |
Serum ferritin levels and polycystic ovary syndrome in obese and nonobese women |
title_short |
Serum ferritin levels and polycystic ovary syndrome in obese and nonobese women |
title_full |
Serum ferritin levels and polycystic ovary syndrome in obese and nonobese women |
title_fullStr |
Serum ferritin levels and polycystic ovary syndrome in obese and nonobese women |
title_full_unstemmed |
Serum ferritin levels and polycystic ovary syndrome in obese and nonobese women |
title_sort |
serum ferritin levels and polycystic ovary syndrome in obese and nonobese women |
publisher |
Elsevier |
series |
Taiwanese Journal of Obstetrics & Gynecology |
issn |
1028-4559 |
publishDate |
2015-08-01 |
description |
Objective: The aim of this study is to evaluate serum ferritin levels and polycystic ovary syndrome (PCOS)-related complications in obese and nonobese women.
Materials and methods: This retrospective study included 539 (286 with PCOS and 253 without PCOS).
Results: Serum ferritin correlated with menstrual cycle length, sex hormone-binding globulin, total testosterone, androstenedione, triglyceride, and total cholesterol in both obese and nonobese women. Obese women with high ferritin levels exhibited higher insulin resistance, impaired glucose tolerance, and liver enzymes (glutamic oxaloacetic transaminase, glutamic pyruvic transaminase) than obese women with low ferritin levels. However, among nonobese women, insulin resistance and risk of diabetes were not significantly different between the high and low ferritin groups. Independent of obesity, hypertriglyceridemia was the major metabolic disturbance observed in women with elevated serum ferritin levels.
Conclusion: Elevated serum ferritin levels are associated with increased insulin resistance and risk of diabetes in obese women but not in nonobese women. However, higher serum ferritin levels were correlated with a greater risk of hyperglyceridemia in both obese and nonobese women. Therefore, hypertriglyceridemia in women with PCOS might be associated with iron metabolism. |
topic |
ferritin insulin resistance metabolic syndrome obesity polycystic ovary syndrome |
url |
http://www.sciencedirect.com/science/article/pii/S1028455915001060 |
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