| Summary: | Read with interest the article by Arias et al on a case of orthodromic atrioventricular reentry (ORT) mediated through the left free wall (LFW) accessory pathway(AP) with an apparently concentric atrial activation sequence [1]. Based on the observation that the atrial signals during the tachycardia were earlier in the His bundle (HB, anterosuperior septum) compared to the proximal coronary sinus (CS, posteroinferior septum), the authors proposed a de novo conduction delay at lateral mitral isthmus (LMI) in this case. However, the electrophysiological correlates of local conduction delay - fractionated electrograms or double potentials - were not documented across LMI to substantiate this. Though the retroaortic route potentially limited recording the endocardial atrial signals, no marked delay in the atrial electrograms between the adjacent CS bipoles was recorded even while CS was deeply cannulated. During ORT, prolonged local VA intervals in mid/proximal, but not in distal CS, bipoles could also represent a conduction delay in the posteroinferior left atrium (LA) immediately medial to the AP insertion. The given intracardiac tracings do not suggest this either. Furthermore, achieving a block across LMI is often difficult during ablative procedures due to the thickened local atrial tissue and /or blood flow of adjacent CS. In a large study, this necessitated epicaridal (inside CS) as well as endocardial ablation in 68%, and radiofrequency delivery exceeding 30 minutes in 20% of cases [2]. These characteristics do make a de novo conduction delay across LMI unlikely in an otherwise normal heart. Authors could have attempted atrial pacing at decremental cycle lengths through the distal CS bipole positioned lateral to LMI to unmask a potential functional delay across LMI and substantiate their hypothesis. This is expected to result in progressive displacement of the collision point of clockwise and anticlockwise impulses in the posteroinferior LA, finally leading to complete reversal of the atrial activation sequence recorded in CS bipoles medial to LMI, in presence of the proposed functional conduction delay at LMI.
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