Dynamic Expression of m6A Regulators During Multiple Human Tissue Development and Cancers

Dynamic Expression of m6A Regulators During Multiple Human Tissue Development and Cancers

N6-methyladenosine (m6A) plays critical roles in human development and cancer progression. However, our knowledge regarding the dynamic expression of m6A regulators during human tissue development is still lacking. Here, we comprehensively analyzed the dynamic expression alterations of m6A regulator...

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Main Authors: Ya Zhang, Sicong Xu, Gang Xu, Yueying Gao, Si Li, Ke Zhang, Zhanyu Tian, Jing Guo, Xia Li, Juan Xu, Yongsheng Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
m6A regulators
tissue development
cancer
gene experession
survival
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.629030/full
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spelling doaj-df2c5b3f822e41f8a10f3dd5c61492bc2021-01-26T07:06:27ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-01-01810.3389/fcell.2020.629030629030Dynamic Expression of m6A Regulators During Multiple Human Tissue Development and CancersYa Zhang0Ya Zhang1Sicong Xu2Sicong Xu3Gang Xu4Gang Xu5Yueying Gao6Yueying Gao7Si Li8Si Li9Ke Zhang10Ke Zhang11Zhanyu Tian12Zhanyu Tian13Jing Guo14Jing Guo15Xia Li16Xia Li17Juan Xu18Juan Xu19Yongsheng Li20Yongsheng Li21Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, ChinaCollege of Biomedical Information and Engineering, Hainan Medical University, Haikou, ChinaKey Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, ChinaCollege of Biomedical Information and Engineering, Hainan Medical University, Haikou, ChinaKey Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, ChinaCollege of Biomedical Information and Engineering, Hainan Medical University, Haikou, ChinaKey Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, ChinaCollege of Biomedical Information and Engineering, Hainan Medical University, Haikou, ChinaKey Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, ChinaCollege of Biomedical Information and Engineering, Hainan Medical University, Haikou, ChinaKey Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, ChinaCollege of Biomedical Information and Engineering, Hainan Medical University, Haikou, ChinaKey Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, ChinaCollege of Biomedical Information and Engineering, Hainan Medical University, Haikou, ChinaKey Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, ChinaCollege of Biomedical Information and Engineering, Hainan Medical University, Haikou, ChinaKey Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, ChinaCollege of Biomedical Information and Engineering, Hainan Medical University, Haikou, ChinaKey Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, ChinaCollege of Biomedical Information and Engineering, Hainan Medical University, Haikou, ChinaKey Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, ChinaCollege of Biomedical Information and Engineering, Hainan Medical University, Haikou, ChinaN6-methyladenosine (m6A) plays critical roles in human development and cancer progression. However, our knowledge regarding the dynamic expression of m6A regulators during human tissue development is still lacking. Here, we comprehensively analyzed the dynamic expression alterations of m6A regulators during seven tissue development and eight cancer types. We found that m6A regulators globally exhibited decreased expression during development. In addition, IGF2BP1/2/3 (insulinlike growth factor 2 MRNA-binding protein 1/2/3) exhibited reverse expression pattern in cancer progression, suggesting an oncofetal reprogramming in cancer. The expressions of IGF2BP1/2/3 were regulated by genome alterations, particularly copy number amplification in cancer. Clinical association analysis revealed that higher expressions of IGF2BP1/2/3 were associated with worse survival of cancer patients. Finally, we found that genes significantly correlated with IGF2BP1/2/3 were significantly enriched in cancer hallmark-related pathways. In summary, dynamic expression analysis will guide both mechanistic and therapeutic roles of m6A regulators during tissue development and cancer progression.https://www.frontiersin.org/articles/10.3389/fcell.2020.629030/fullm6A regulatorstissue developmentcancergene experessionsurvival
collection DOAJ
language English
format Article
sources DOAJ
author Ya Zhang
Ya Zhang
Sicong Xu
Sicong Xu
Gang Xu
Gang Xu
Yueying Gao
Yueying Gao
Si Li
Si Li
Ke Zhang
Ke Zhang
Zhanyu Tian
Zhanyu Tian
Jing Guo
Jing Guo
Xia Li
Xia Li
Juan Xu
Juan Xu
Yongsheng Li
Yongsheng Li
spellingShingle Ya Zhang
Ya Zhang
Sicong Xu
Sicong Xu
Gang Xu
Gang Xu
Yueying Gao
Yueying Gao
Si Li
Si Li
Ke Zhang
Ke Zhang
Zhanyu Tian
Zhanyu Tian
Jing Guo
Jing Guo
Xia Li
Xia Li
Juan Xu
Juan Xu
Yongsheng Li
Yongsheng Li
Dynamic Expression of m6A Regulators During Multiple Human Tissue Development and Cancers
Frontiers in Cell and Developmental Biology
m6A regulators
tissue development
cancer
gene experession
survival
author_facet Ya Zhang
Ya Zhang
Sicong Xu
Sicong Xu
Gang Xu
Gang Xu
Yueying Gao
Yueying Gao
Si Li
Si Li
Ke Zhang
Ke Zhang
Zhanyu Tian
Zhanyu Tian
Jing Guo
Jing Guo
Xia Li
Xia Li
Juan Xu
Juan Xu
Yongsheng Li
Yongsheng Li
author_sort Ya Zhang
title Dynamic Expression of m6A Regulators During Multiple Human Tissue Development and Cancers
title_short Dynamic Expression of m6A Regulators During Multiple Human Tissue Development and Cancers
title_full Dynamic Expression of m6A Regulators During Multiple Human Tissue Development and Cancers
title_fullStr Dynamic Expression of m6A Regulators During Multiple Human Tissue Development and Cancers
title_full_unstemmed Dynamic Expression of m6A Regulators During Multiple Human Tissue Development and Cancers
title_sort dynamic expression of m6a regulators during multiple human tissue development and cancers
publisher Frontiers Media S.A.
series Frontiers in Cell and Developmental Biology
issn 2296-634X
publishDate 2021-01-01
description N6-methyladenosine (m6A) plays critical roles in human development and cancer progression. However, our knowledge regarding the dynamic expression of m6A regulators during human tissue development is still lacking. Here, we comprehensively analyzed the dynamic expression alterations of m6A regulators during seven tissue development and eight cancer types. We found that m6A regulators globally exhibited decreased expression during development. In addition, IGF2BP1/2/3 (insulinlike growth factor 2 MRNA-binding protein 1/2/3) exhibited reverse expression pattern in cancer progression, suggesting an oncofetal reprogramming in cancer. The expressions of IGF2BP1/2/3 were regulated by genome alterations, particularly copy number amplification in cancer. Clinical association analysis revealed that higher expressions of IGF2BP1/2/3 were associated with worse survival of cancer patients. Finally, we found that genes significantly correlated with IGF2BP1/2/3 were significantly enriched in cancer hallmark-related pathways. In summary, dynamic expression analysis will guide both mechanistic and therapeutic roles of m6A regulators during tissue development and cancer progression.
topic m6A regulators
tissue development
cancer
gene experession
survival
url https://www.frontiersin.org/articles/10.3389/fcell.2020.629030/full
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