A Dietary Intervention with Reduction of Starch and Sucrose Leads to Reduced Gastrointestinal and Extra-Intestinal Symptoms in IBS Patients
Patients with irritable bowel syndrome (IBS) exhibit low-grade inflammation and increased gut permeability. Dietary sugar has been shown to contribute to low-grade inflammation and increased gut permeability, and to correlate with gastrointestinal (GI) symptoms. The aim of the present study was to e...
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doaj-df345d0a621343059ab21eaa8c1b29052020-11-25T00:32:08ZengMDPI AGNutrients2072-66432019-07-01117166210.3390/nu11071662nu11071662A Dietary Intervention with Reduction of Starch and Sucrose Leads to Reduced Gastrointestinal and Extra-Intestinal Symptoms in IBS PatientsClara Nilholm0Bodil Roth1Bodil Ohlsson2Department of Internal Medicine, Lund University, Skåne University Hospital, 205 02 Malmö, SwedenDepartment of Internal Medicine, Lund University, Skåne University Hospital, 205 02 Malmö, SwedenDepartment of Internal Medicine, Lund University, Skåne University Hospital, 205 02 Malmö, SwedenPatients with irritable bowel syndrome (IBS) exhibit low-grade inflammation and increased gut permeability. Dietary sugar has been shown to contribute to low-grade inflammation and increased gut permeability, and to correlate with gastrointestinal (GI) symptoms. The aim of the present study was to examine the effect of a starch- and sucrose-reduced diet (SSRD) on gastrointestinal (GI) and extra-intestinal symptoms in IBS. One hundred and five IBS patients (82 women, 46.06 ± 13.11 years), with irritable bowel syndrome-symptom severity scale (IBS-SSS) > 175, were randomized to SSRD for 4 weeks or continued ordinary eating habits. The visual analog scale for irritable bowel syndrome (VAS-IBS), IBS-SSS, and 4-day food diaries were collected at baseline and after 2 and 4 weeks. After the intervention, one-third of the patients did not fulfill the criteria for IBS/functional gastrointestinal disorder. Half of the participants changed from moderate/severe disease to no/mild disease according to IBS-SSS. Comparisons between the groups showed decreased weight and sweet cravings, and parallel decreases in total IBS-SSS and extra-intestinal IBS-SSS scores, in the intervention group compared to controls (<i>p</i> < 0.001 for all). When calculating separate extra-intestinal symptoms, belching (<i>p</i> = 0.001), muscle/joint pain (<i>p</i> = 0.029), urinary urgency (<i>p</i> = 0.017), and tiredness (<i>p</i> = 0.011) were decreased after introduction of SSRD compared to controls. In conclusion, SSRD improves both GI and extra-intestinal symptoms in IBS.https://www.mdpi.com/2072-6643/11/7/1662dietextra-intestinal symptomsgastrointestinal symptomsirritable bowel syndromestarchsucrose |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Clara Nilholm Bodil Roth Bodil Ohlsson |
spellingShingle |
Clara Nilholm Bodil Roth Bodil Ohlsson A Dietary Intervention with Reduction of Starch and Sucrose Leads to Reduced Gastrointestinal and Extra-Intestinal Symptoms in IBS Patients Nutrients diet extra-intestinal symptoms gastrointestinal symptoms irritable bowel syndrome starch sucrose |
author_facet |
Clara Nilholm Bodil Roth Bodil Ohlsson |
author_sort |
Clara Nilholm |
title |
A Dietary Intervention with Reduction of Starch and Sucrose Leads to Reduced Gastrointestinal and Extra-Intestinal Symptoms in IBS Patients |
title_short |
A Dietary Intervention with Reduction of Starch and Sucrose Leads to Reduced Gastrointestinal and Extra-Intestinal Symptoms in IBS Patients |
title_full |
A Dietary Intervention with Reduction of Starch and Sucrose Leads to Reduced Gastrointestinal and Extra-Intestinal Symptoms in IBS Patients |
title_fullStr |
A Dietary Intervention with Reduction of Starch and Sucrose Leads to Reduced Gastrointestinal and Extra-Intestinal Symptoms in IBS Patients |
title_full_unstemmed |
A Dietary Intervention with Reduction of Starch and Sucrose Leads to Reduced Gastrointestinal and Extra-Intestinal Symptoms in IBS Patients |
title_sort |
dietary intervention with reduction of starch and sucrose leads to reduced gastrointestinal and extra-intestinal symptoms in ibs patients |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2019-07-01 |
description |
Patients with irritable bowel syndrome (IBS) exhibit low-grade inflammation and increased gut permeability. Dietary sugar has been shown to contribute to low-grade inflammation and increased gut permeability, and to correlate with gastrointestinal (GI) symptoms. The aim of the present study was to examine the effect of a starch- and sucrose-reduced diet (SSRD) on gastrointestinal (GI) and extra-intestinal symptoms in IBS. One hundred and five IBS patients (82 women, 46.06 ± 13.11 years), with irritable bowel syndrome-symptom severity scale (IBS-SSS) > 175, were randomized to SSRD for 4 weeks or continued ordinary eating habits. The visual analog scale for irritable bowel syndrome (VAS-IBS), IBS-SSS, and 4-day food diaries were collected at baseline and after 2 and 4 weeks. After the intervention, one-third of the patients did not fulfill the criteria for IBS/functional gastrointestinal disorder. Half of the participants changed from moderate/severe disease to no/mild disease according to IBS-SSS. Comparisons between the groups showed decreased weight and sweet cravings, and parallel decreases in total IBS-SSS and extra-intestinal IBS-SSS scores, in the intervention group compared to controls (<i>p</i> < 0.001 for all). When calculating separate extra-intestinal symptoms, belching (<i>p</i> = 0.001), muscle/joint pain (<i>p</i> = 0.029), urinary urgency (<i>p</i> = 0.017), and tiredness (<i>p</i> = 0.011) were decreased after introduction of SSRD compared to controls. In conclusion, SSRD improves both GI and extra-intestinal symptoms in IBS. |
topic |
diet extra-intestinal symptoms gastrointestinal symptoms irritable bowel syndrome starch sucrose |
url |
https://www.mdpi.com/2072-6643/11/7/1662 |
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