Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells
Factor XII initiates the intrinsic blood coagulation cascade and the kinin system. Here the authors show that Factor XII is elevated in the blood of multiple sclerosis patients, activates dendritic cells via CD87 and cAMP, and its blockade inhibits immunopathology in a mouse model of the disease.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2016-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms11626 |
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doaj-df39268cbc9348e48bfb9cdea92d808d |
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| record_format |
Article |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Kerstin Göbel Susann Pankratz Chloi-Magdalini Asaridou Alexander M. Herrmann Stefan Bittner Monika Merker Tobias Ruck Sarah Glumm Friederike Langhauser Peter Kraft Thorsten F. Krug Johanna Breuer Martin Herold Catharina C. Gross Denise Beckmann Adelheid Korb-Pap Michael K. Schuhmann Stefanie Kuerten Ioannis Mitroulis Clemens Ruppert Marc W. Nolte Con Panousis Luisa Klotz Beate Kehrel Thomas Korn Harald F. Langer Thomas Pap Bernhard Nieswandt Heinz Wiendl Triantafyllos Chavakis Christoph Kleinschnitz Sven G. Meuth |
| spellingShingle |
Kerstin Göbel Susann Pankratz Chloi-Magdalini Asaridou Alexander M. Herrmann Stefan Bittner Monika Merker Tobias Ruck Sarah Glumm Friederike Langhauser Peter Kraft Thorsten F. Krug Johanna Breuer Martin Herold Catharina C. Gross Denise Beckmann Adelheid Korb-Pap Michael K. Schuhmann Stefanie Kuerten Ioannis Mitroulis Clemens Ruppert Marc W. Nolte Con Panousis Luisa Klotz Beate Kehrel Thomas Korn Harald F. Langer Thomas Pap Bernhard Nieswandt Heinz Wiendl Triantafyllos Chavakis Christoph Kleinschnitz Sven G. Meuth Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells Nature Communications |
| author_facet |
Kerstin Göbel Susann Pankratz Chloi-Magdalini Asaridou Alexander M. Herrmann Stefan Bittner Monika Merker Tobias Ruck Sarah Glumm Friederike Langhauser Peter Kraft Thorsten F. Krug Johanna Breuer Martin Herold Catharina C. Gross Denise Beckmann Adelheid Korb-Pap Michael K. Schuhmann Stefanie Kuerten Ioannis Mitroulis Clemens Ruppert Marc W. Nolte Con Panousis Luisa Klotz Beate Kehrel Thomas Korn Harald F. Langer Thomas Pap Bernhard Nieswandt Heinz Wiendl Triantafyllos Chavakis Christoph Kleinschnitz Sven G. Meuth |
| author_sort |
Kerstin Göbel |
| title |
Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells |
| title_short |
Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells |
| title_full |
Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells |
| title_fullStr |
Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells |
| title_full_unstemmed |
Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells |
| title_sort |
blood coagulation factor xii drives adaptive immunity during neuroinflammation via cd87-mediated modulation of dendritic cells |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2016-05-01 |
| description |
Factor XII initiates the intrinsic blood coagulation cascade and the kinin system. Here the authors show that Factor XII is elevated in the blood of multiple sclerosis patients, activates dendritic cells via CD87 and cAMP, and its blockade inhibits immunopathology in a mouse model of the disease. |
| url |
https://doi.org/10.1038/ncomms11626 |
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1721447088277946368 |
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doaj-df39268cbc9348e48bfb9cdea92d808d2021-05-11T11:05:20ZengNature Publishing GroupNature Communications2041-17232016-05-017111610.1038/ncomms11626Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cellsKerstin Göbel0Susann Pankratz1Chloi-Magdalini Asaridou2Alexander M. Herrmann3Stefan Bittner4Monika Merker5Tobias Ruck6Sarah Glumm7Friederike Langhauser8Peter Kraft9Thorsten F. Krug10Johanna Breuer11Martin Herold12Catharina C. Gross13Denise Beckmann14Adelheid Korb-Pap15Michael K. Schuhmann16Stefanie Kuerten17Ioannis Mitroulis18Clemens Ruppert19Marc W. Nolte20Con Panousis21Luisa Klotz22Beate Kehrel23Thomas Korn24Harald F. Langer25Thomas Pap26Bernhard Nieswandt27Heinz Wiendl28Triantafyllos Chavakis29Christoph Kleinschnitz30Sven G. Meuth31Department of Neurology, Clinic of Neurology and Institute for Translational Neurology, University of MünsterDepartment of Neurology, Clinic of Neurology and Institute for Translational Neurology, University of MünsterDepartment of Neurology, Clinic of Neurology and Institute for Translational Neurology, University of MünsterDepartment of Neurology, Clinic of Neurology and Institute for Translational Neurology, University of MünsterDepartment of Neurology, Clinic of Neurology and Institute for Translational Neurology, University of MünsterDepartment of Neurology, Clinic of Neurology and Institute for Translational Neurology, University of MünsterDepartment of Neurology, Clinic of Neurology and Institute for Translational Neurology, University of MünsterDepartment of Neurology, Clinic of Neurology and Institute for Translational Neurology, University of MünsterDepartment of Neurology, University Hospital WürzburgDepartment of Neurology, University Hospital WürzburgDepartment of Neurology, Clinic of Neurology and Institute for Translational Neurology, University of MünsterDepartment of Neurology, Clinic of Neurology and Institute for Translational Neurology, University of MünsterDepartment of Neurology, Clinic of Neurology and Institute for Translational Neurology, University of MünsterDepartment of Neurology, Clinic of Neurology and Institute for Translational Neurology, University of MünsterInstitute of Experimental Musculoskeletal Medicine, University Hospital MünsterInstitute of Experimental Musculoskeletal Medicine, University Hospital MünsterDepartment of Neurology, University Hospital WürzburgDepartment of Anatomy and Cell Biology, University of WürzburgDepartment of Clinical Pathobiochemistry and Institute for Clinical Chemistry and Laboratory Medicine, University Clinic Carl Gustav Carus, Technische Universität of DresdenDepartment of Internal Medicine, Universities of Giessen & Marburg Lung Center (UGMLC)/Member of the German Center for Lung Research (DZL), Justus-Liebig UniversityCSL Behring GmbHCSL Limited, Bio21 InstituteDepartment of Neurology, Clinic of Neurology and Institute for Translational Neurology, University of MünsterDepartment of Anesthesiology, Intensive Care and Pain Medicine, Experimental and Clinical Hemostasis, University of MünsterDepartment of Neurology, Klinikum rechts der Isar, Technical University of MunichDepartment of Cardiology and Cardiovascular Medicine, Section for Cardioimmunology, University Clinic of TübingenInstitute of Experimental Musculoskeletal Medicine, University Hospital MünsterRudolf Virchow Center, Deutsche Forschungsgemeinschaft Research Center for Experimental Biomedicine, University of WürzburgDepartment of Neurology, Clinic of Neurology and Institute for Translational Neurology, University of MünsterDepartment of Clinical Pathobiochemistry and Institute for Clinical Chemistry and Laboratory Medicine, University Clinic Carl Gustav Carus, Technische Universität of DresdenDepartment of Neurology, University Hospital WürzburgDepartment of Neurology, Clinic of Neurology and Institute for Translational Neurology, University of MünsterFactor XII initiates the intrinsic blood coagulation cascade and the kinin system. Here the authors show that Factor XII is elevated in the blood of multiple sclerosis patients, activates dendritic cells via CD87 and cAMP, and its blockade inhibits immunopathology in a mouse model of the disease.https://doi.org/10.1038/ncomms11626 |