Comparison of the Effects of Glycyrrhiza Glabra Vaginal Cream and Clotrimazole on the Symptoms of Fungal Vulvovaginitis
Background & Aims: Candidiasis accounts for 50-90% of vaginal infections in women. Resistance to azole drugs has prompted research into new drugs for the treatment of vaginal infections. The present study aimed to compare the effects of Glycyrrhiza Glabra vaginal cream and clotrimazole on the sy...
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doaj-df3ed334aae84a928dcd04bca29254132020-11-25T03:01:11ZfasIran University of Medical Sciencesنشریه پرستاری ایران2008-59312019-04-01321172230Comparison of the Effects of Glycyrrhiza Glabra Vaginal Cream and Clotrimazole on the Symptoms of Fungal VulvovaginitisN Dodangeh0M Kheirkhah1J Abolghasemi2F Mojab3F Farshad4 MS in Midwifery, School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran Assistant Professor, Department of Midwifery and Reproductive Health, Nursing Care Research Center, School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran (*Corresponding author) Tel: 09124787691 Email: kheirkhah.m@iums.ac.ir Assistant Professor, Department of Biostatistics, School of Public Health, Iran University of Medical Sciences, Tehran, Iran Professor, Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran Dentistry Student, Tehran University of Medical Sciences, Tehran, Iran Background & Aims: Candidiasis accounts for 50-90% of vaginal infections in women. Resistance to azole drugs has prompted research into new drugs for the treatment of vaginal infections. The present study aimed to compare the effects of Glycyrrhiza Glabra vaginal cream and clotrimazole on the symptoms of fungal vulvovaginitis. Materials & Methods: This triple-blind clinical trial was conducted on 60 women with candida vaginitis. The inclusion criteria were the presence of two symptoms of fungal vulvovaginitis (itching, burning, discharge, dyspareunia, and dysuria) and positive vaginal smear. After obtaining informed consent, eligible subjects chose the cards A or B and were assigned to each study group. The patients used an applicator containing clotrimazole or Glycyrrhiza Glabra vaginal cream every night, which were prepared in identical tubes (50 mg) and labeled A or B by a pharmacist. Data were collected using demographic and fertility forms, a checklist of clinical observations, and a record of the results of vaginal smear. After completing the treatment period for seven days, the subjects referred to the gynecological clinic again for examination and vaginal smears. Data analysis was performed in SPSS version 16 using Chi-square, McNemar's test, and generalized estimating equation. Results: The results of vaginal smear and improved symptoms of vulvovaginitis (discharge, dyspareunia, irritation, and irritation) were similar in clotrimazole and Glycyrrhiza Glabra groups, while the improvement of the symptoms of itching and burning was more significant in the clotrimazole group compared to the Glycyrrhiza glabra group. Conclusion: According to the results, Glycyrrhiza Glabra vaginal cream could be used as an adjunct therapy to major treatments in the women who are willing to use herbal medication. Therefore, it should be recommended to midwives and gynecologists.http://ijn.iums.ac.ir/article-1-2881-en.htmlvulvovaginitiscandidaglycyrrhiza glabraclotrimazole |
collection |
DOAJ |
language |
fas |
format |
Article |
sources |
DOAJ |
author |
N Dodangeh M Kheirkhah J Abolghasemi F Mojab F Farshad |
spellingShingle |
N Dodangeh M Kheirkhah J Abolghasemi F Mojab F Farshad Comparison of the Effects of Glycyrrhiza Glabra Vaginal Cream and Clotrimazole on the Symptoms of Fungal Vulvovaginitis نشریه پرستاری ایران vulvovaginitis candida glycyrrhiza glabra clotrimazole |
author_facet |
N Dodangeh M Kheirkhah J Abolghasemi F Mojab F Farshad |
author_sort |
N Dodangeh |
title |
Comparison of the Effects of Glycyrrhiza Glabra Vaginal Cream and Clotrimazole on the Symptoms of Fungal Vulvovaginitis |
title_short |
Comparison of the Effects of Glycyrrhiza Glabra Vaginal Cream and Clotrimazole on the Symptoms of Fungal Vulvovaginitis |
title_full |
Comparison of the Effects of Glycyrrhiza Glabra Vaginal Cream and Clotrimazole on the Symptoms of Fungal Vulvovaginitis |
title_fullStr |
Comparison of the Effects of Glycyrrhiza Glabra Vaginal Cream and Clotrimazole on the Symptoms of Fungal Vulvovaginitis |
title_full_unstemmed |
Comparison of the Effects of Glycyrrhiza Glabra Vaginal Cream and Clotrimazole on the Symptoms of Fungal Vulvovaginitis |
title_sort |
comparison of the effects of glycyrrhiza glabra vaginal cream and clotrimazole on the symptoms of fungal vulvovaginitis |
publisher |
Iran University of Medical Sciences |
series |
نشریه پرستاری ایران |
issn |
2008-5931 |
publishDate |
2019-04-01 |
description |
Background & Aims: Candidiasis accounts for 50-90% of vaginal infections in women. Resistance to azole drugs has prompted research into new drugs for the treatment of vaginal infections. The present study aimed to compare the effects of Glycyrrhiza Glabra vaginal cream and clotrimazole on the symptoms of fungal vulvovaginitis.
Materials & Methods: This triple-blind clinical trial was conducted on 60 women with candida vaginitis. The inclusion criteria were the presence of two symptoms of fungal vulvovaginitis (itching, burning, discharge, dyspareunia, and dysuria) and positive vaginal smear. After obtaining informed consent, eligible subjects chose the cards A or B and were assigned to each study group. The patients used an applicator containing clotrimazole or Glycyrrhiza Glabra vaginal cream every night, which were prepared in identical tubes (50 mg) and labeled A or B by a pharmacist. Data were collected using demographic and fertility forms, a checklist of clinical observations, and a record of the results of vaginal smear. After completing the treatment period for seven days, the subjects referred to the gynecological clinic again for examination and vaginal smears. Data analysis was performed in SPSS version 16 using Chi-square, McNemar's test, and generalized estimating equation.
Results: The results of vaginal smear and improved symptoms of vulvovaginitis (discharge, dyspareunia, irritation, and irritation) were similar in clotrimazole and Glycyrrhiza Glabra groups, while the improvement of the symptoms of itching and burning was more significant in the clotrimazole group compared to the Glycyrrhiza glabra group.
Conclusion: According to the results, Glycyrrhiza Glabra vaginal cream could be used as an adjunct therapy to major treatments in the women who are willing to use herbal medication. Therefore, it should be recommended to midwives and gynecologists. |
topic |
vulvovaginitis candida glycyrrhiza glabra clotrimazole |
url |
http://ijn.iums.ac.ir/article-1-2881-en.html |
work_keys_str_mv |
AT ndodangeh comparisonoftheeffectsofglycyrrhizaglabravaginalcreamandclotrimazoleonthesymptomsoffungalvulvovaginitis AT mkheirkhah comparisonoftheeffectsofglycyrrhizaglabravaginalcreamandclotrimazoleonthesymptomsoffungalvulvovaginitis AT jabolghasemi comparisonoftheeffectsofglycyrrhizaglabravaginalcreamandclotrimazoleonthesymptomsoffungalvulvovaginitis AT fmojab comparisonoftheeffectsofglycyrrhizaglabravaginalcreamandclotrimazoleonthesymptomsoffungalvulvovaginitis AT ffarshad comparisonoftheeffectsofglycyrrhizaglabravaginalcreamandclotrimazoleonthesymptomsoffungalvulvovaginitis |
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