The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry
The implementation of continuous flow processing as a key enabling technology has transformed the way we conduct chemistry and has expanded our synthetic capabilities. As a result many new preparative routes have been designed towards commercially relevant drug compounds achieving more efficient and...
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Online Access: | https://doi.org/10.3762/bjoc.11.134 |
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doaj-df50eedeb4a7418b98123d5219c9b70f2021-02-02T01:03:04ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972015-07-011111194121910.3762/bjoc.11.1341860-5397-11-134The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistryMarcus Baumann0Ian R. Baxendale1Department of Chemistry, Durham University, South Road, DH1 3LE Durham, United KingdomDepartment of Chemistry, Durham University, South Road, DH1 3LE Durham, United KingdomThe implementation of continuous flow processing as a key enabling technology has transformed the way we conduct chemistry and has expanded our synthetic capabilities. As a result many new preparative routes have been designed towards commercially relevant drug compounds achieving more efficient and reproducible manufacture. This review article aims to illustrate the holistic systems approach and diverse applications of flow chemistry to the preparation of pharmaceutically active molecules, demonstrating the value of this strategy towards every aspect ranging from synthesis, in-line analysis and purification to final formulation and tableting. Although this review will primarily concentrate on large scale continuous processing, additional selected syntheses using micro or meso-scaled flow reactors will be exemplified for key transformations and process control. It is hoped that the reader will gain an appreciation of the innovative technology and transformational nature that flow chemistry can leverage to an overall process.https://doi.org/10.3762/bjoc.11.134continuous processingflow synthesisin-line analysismanufacturepharmaceuticalsscalability |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marcus Baumann Ian R. Baxendale |
spellingShingle |
Marcus Baumann Ian R. Baxendale The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry Beilstein Journal of Organic Chemistry continuous processing flow synthesis in-line analysis manufacture pharmaceuticals scalability |
author_facet |
Marcus Baumann Ian R. Baxendale |
author_sort |
Marcus Baumann |
title |
The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry |
title_short |
The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry |
title_full |
The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry |
title_fullStr |
The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry |
title_full_unstemmed |
The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry |
title_sort |
synthesis of active pharmaceutical ingredients (apis) using continuous flow chemistry |
publisher |
Beilstein-Institut |
series |
Beilstein Journal of Organic Chemistry |
issn |
1860-5397 |
publishDate |
2015-07-01 |
description |
The implementation of continuous flow processing as a key enabling technology has transformed the way we conduct chemistry and has expanded our synthetic capabilities. As a result many new preparative routes have been designed towards commercially relevant drug compounds achieving more efficient and reproducible manufacture. This review article aims to illustrate the holistic systems approach and diverse applications of flow chemistry to the preparation of pharmaceutically active molecules, demonstrating the value of this strategy towards every aspect ranging from synthesis, in-line analysis and purification to final formulation and tableting. Although this review will primarily concentrate on large scale continuous processing, additional selected syntheses using micro or meso-scaled flow reactors will be exemplified for key transformations and process control. It is hoped that the reader will gain an appreciation of the innovative technology and transformational nature that flow chemistry can leverage to an overall process. |
topic |
continuous processing flow synthesis in-line analysis manufacture pharmaceuticals scalability |
url |
https://doi.org/10.3762/bjoc.11.134 |
work_keys_str_mv |
AT marcusbaumann thesynthesisofactivepharmaceuticalingredientsapisusingcontinuousflowchemistry AT ianrbaxendale thesynthesisofactivepharmaceuticalingredientsapisusingcontinuousflowchemistry AT marcusbaumann synthesisofactivepharmaceuticalingredientsapisusingcontinuousflowchemistry AT ianrbaxendale synthesisofactivepharmaceuticalingredientsapisusingcontinuousflowchemistry |
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