Ethanol exposure increases mutation rate through error-prone polymerases
Whereas the toxic effects of ethanol are well-documented, the underlying mechanism is obscure. This study uses the eukaryotic model S. cerevisiae to reveal how exposure to sublethal ethanol concentrations causes DNA replication stress and an increased mutation rate.
Bibliographic Details
| Main Authors: |
Karin Voordeckers,
Camilla Colding,
Lavinia Grasso,
Benjamin Pardo,
Lore Hoes,
Jacek Kominek,
Kim Gielens,
Kaat Dekoster,
Jonathan Gordon,
Elisa Van der Zande,
Peter Bircham,
Toon Swings,
Jan Michiels,
Peter Van Loo,
Sandra Nuyts,
Philippe Pasero,
Michael Lisby,
Kevin J. Verstrepen |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2020-07-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-020-17447-3
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