Circular RNA: A potential diagnostic, prognostic, and therapeutic biomarker for human triple-negative breast cancer
Triple-negative breast cancer (TNBC), which is the most malignant subtype of breast cancer (BC), accounts for 10%–20% of all BC cases. TNBC, which occurs more frequently in young women, is characterized by high rates of cell proliferation and metastasis and poor prognosis. Chemotherapy is the primar...
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doaj-df5c55fa260246f2a514ff2e82f44b502021-09-01T04:20:51ZengElsevierMolecular Therapy: Nucleic Acids2162-25312021-12-01266380Circular RNA: A potential diagnostic, prognostic, and therapeutic biomarker for human triple-negative breast cancerTian Tian0Yangzhi Zhao1Jingying Zheng2Shunzi Jin3Zhongshan Liu4Tiejun Wang5Department of Radiation Oncology, The Second Affiliated Hospital of Jilin University, Changchun 130041, ChinaDepartment of Hematology, The First Hospital of Jilin University, Changchun 130021, ChinaDepartment of Gynecology and Obstetrics, The Second Affiliated Hospital of Jilin University, Changchun 130041, ChinaNHC Key Laboratory of Radiobiology, Jilin University, Changchun 130021, ChinaDepartment of Radiation Oncology, The Second Affiliated Hospital of Jilin University, Changchun 130041, China; Corresponding author: Zhongshan Liu, Department of Radiation Oncology, The Second Affiliated Hospital of Jilin University, Changchun 130041, China.Department of Radiation Oncology, The Second Affiliated Hospital of Jilin University, Changchun 130041, China; Corresponding author: Tiejun Wang, Department of Department of Radiation Oncology, The Second Affiliated Hospital of Jilin University, Changchun 130041, China.Triple-negative breast cancer (TNBC), which is the most malignant subtype of breast cancer (BC), accounts for 10%–20% of all BC cases. TNBC, which occurs more frequently in young women, is characterized by high rates of cell proliferation and metastasis and poor prognosis. Chemotherapy is the primary systemic therapeutic strategy for TNBC. However, chemotherapy is largely unsuccessful, and effective targeted therapies for TNBC have not been established. Therefore, it is a matter of great urgency to identify precise molecular targets for the promising prognosis of patients with TNBC. Circular RNAs (circRNAs), which are a type of non-coding RNAs (ncRNAs), are abundantly expressed in the eukaryotic cells and exhibit diverse cellular functions. The roles of circRNAs are to sponge microRNA or RNA-binding proteins, regulate gene expression, and serve as templates for translation. Here, we review the current findings on the potential of circRNAs as a diagnostic, prognostic, and therapeutic biomarker for TNBC. However, further studies are essential to elucidate the functions of circRNAs in TNBC. This review also discusses the current limitations and future directions of TNBC-associated circRNAs, which can facilitate the translation of experimental research into clinical application.http://www.sciencedirect.com/science/article/pii/S216225312100158Xcircular RNAstriple-negative breast cancerbiomarkerdiagnosisprognosistherapeutic potential |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tian Tian Yangzhi Zhao Jingying Zheng Shunzi Jin Zhongshan Liu Tiejun Wang |
spellingShingle |
Tian Tian Yangzhi Zhao Jingying Zheng Shunzi Jin Zhongshan Liu Tiejun Wang Circular RNA: A potential diagnostic, prognostic, and therapeutic biomarker for human triple-negative breast cancer Molecular Therapy: Nucleic Acids circular RNAs triple-negative breast cancer biomarker diagnosis prognosis therapeutic potential |
author_facet |
Tian Tian Yangzhi Zhao Jingying Zheng Shunzi Jin Zhongshan Liu Tiejun Wang |
author_sort |
Tian Tian |
title |
Circular RNA: A potential diagnostic, prognostic, and therapeutic biomarker for human triple-negative breast cancer |
title_short |
Circular RNA: A potential diagnostic, prognostic, and therapeutic biomarker for human triple-negative breast cancer |
title_full |
Circular RNA: A potential diagnostic, prognostic, and therapeutic biomarker for human triple-negative breast cancer |
title_fullStr |
Circular RNA: A potential diagnostic, prognostic, and therapeutic biomarker for human triple-negative breast cancer |
title_full_unstemmed |
Circular RNA: A potential diagnostic, prognostic, and therapeutic biomarker for human triple-negative breast cancer |
title_sort |
circular rna: a potential diagnostic, prognostic, and therapeutic biomarker for human triple-negative breast cancer |
publisher |
Elsevier |
series |
Molecular Therapy: Nucleic Acids |
issn |
2162-2531 |
publishDate |
2021-12-01 |
description |
Triple-negative breast cancer (TNBC), which is the most malignant subtype of breast cancer (BC), accounts for 10%–20% of all BC cases. TNBC, which occurs more frequently in young women, is characterized by high rates of cell proliferation and metastasis and poor prognosis. Chemotherapy is the primary systemic therapeutic strategy for TNBC. However, chemotherapy is largely unsuccessful, and effective targeted therapies for TNBC have not been established. Therefore, it is a matter of great urgency to identify precise molecular targets for the promising prognosis of patients with TNBC. Circular RNAs (circRNAs), which are a type of non-coding RNAs (ncRNAs), are abundantly expressed in the eukaryotic cells and exhibit diverse cellular functions. The roles of circRNAs are to sponge microRNA or RNA-binding proteins, regulate gene expression, and serve as templates for translation. Here, we review the current findings on the potential of circRNAs as a diagnostic, prognostic, and therapeutic biomarker for TNBC. However, further studies are essential to elucidate the functions of circRNAs in TNBC. This review also discusses the current limitations and future directions of TNBC-associated circRNAs, which can facilitate the translation of experimental research into clinical application. |
topic |
circular RNAs triple-negative breast cancer biomarker diagnosis prognosis therapeutic potential |
url |
http://www.sciencedirect.com/science/article/pii/S216225312100158X |
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