Histopathological evaluation of the effect of swimming training on ethylene glycol-induced crystal deposition in urinary system and its related damage in rats

• Main Authors: Ezzatifar M, Rahmani M, Hassanpour-Ezatti M
• Format: Article
• Language: fas
• Published: Kashan University of Medical Sciences and Health Services 2020-05-01
• Series: Fiyz̤
• Subjects: ethylene glycol; swimming training; nephrolithiasis; rats
• Online Access: http://feyz.kaums.ac.ir/article-1-3815-en.html

Background: The evaluation of exercise effects on the prevention of various diseases is one of the major research fields. In this research, the effect of swimming training on the prevention of kidney crystal deposit and damages induced by ethylene glycol was investigated. Materials and Methods: In this experimental study, 24 rats were randomly divided into four groups: Control (C), treated with: ethylene glycol 1%(EG), swimming training (SW) and (EG+SW) group that concurrently received ethylene glycol 1%+ swimming practice. Rats in EG and EG+SW groups received 4 weeks drinking water containing1% ethylene glycol. The rats in SW and EG+SW groups were performed swimming training over 6 weeks, three sessions a week for 45 minutes. At the end of the swimming session, rats were euthanized, and kidneys, ureters and bladder tissue samples were histologically evaluated after haematoxylin & eosin staining. Results: Crystal deposition were observed in all urinary system epithelium surfaces together with renal damages in EG-treated rats, but not observed in urinary system tissue samples of C and SW groups. Renal crystals were detected in renal tissues of EG+SW group was lower than EG group. The total stones were detected in the renal tissue, ureters and bladder and its size in the EG+SW group were significantly lower than EG group (P=0.003). Renal tissue damages of EG+SW group due to ethylene glycol were much less pronounced than EG group. Conclusion: The swimming training can prevent from renal stones formation induced by ethylene glycol and reduce the tissue damage caused by it.