Highly parallel lab evolution reveals that epistasis can curb the evolution of antibiotic resistance

Highly parallel lab evolution reveals that epistasis can curb the evolution of antibiotic resistance

The antibiotic resistance crisis calls for new ways of restricting the ability of bacteria to evolve resistance. Here, Lukačišinová et al. perform highly controlled evolution experiments in E. coli strains to identify genetic perturbations that strongly limit the evolution of antibiotic resistance t...

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Main Authors: Marta Lukačišinová, Booshini Fernando, Tobias Bollenbach
Format: Article
Language:English
Published: Nature Publishing Group 2020-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16932-z
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spelling doaj-df72a91427cc44d6b277ce9d4f48db762021-06-20T11:14:59ZengNature Publishing GroupNature Communications2041-17232020-06-0111111410.1038/s41467-020-16932-zHighly parallel lab evolution reveals that epistasis can curb the evolution of antibiotic resistanceMarta Lukačišinová0Booshini Fernando1Tobias Bollenbach2University of Cologne, Institute for Biological PhysicsUniversity of Cologne, Institute for Biological PhysicsUniversity of Cologne, Institute for Biological PhysicsThe antibiotic resistance crisis calls for new ways of restricting the ability of bacteria to evolve resistance. Here, Lukačišinová et al. perform highly controlled evolution experiments in E. coli strains to identify genetic perturbations that strongly limit the evolution of antibiotic resistance through epistasis.https://doi.org/10.1038/s41467-020-16932-z
collection DOAJ
language English
format Article
sources DOAJ
author Marta Lukačišinová
Booshini Fernando
Tobias Bollenbach
spellingShingle Marta Lukačišinová
Booshini Fernando
Tobias Bollenbach
Highly parallel lab evolution reveals that epistasis can curb the evolution of antibiotic resistance
Nature Communications
author_facet Marta Lukačišinová
Booshini Fernando
Tobias Bollenbach
author_sort Marta Lukačišinová
title Highly parallel lab evolution reveals that epistasis can curb the evolution of antibiotic resistance
title_short Highly parallel lab evolution reveals that epistasis can curb the evolution of antibiotic resistance
title_full Highly parallel lab evolution reveals that epistasis can curb the evolution of antibiotic resistance
title_fullStr Highly parallel lab evolution reveals that epistasis can curb the evolution of antibiotic resistance
title_full_unstemmed Highly parallel lab evolution reveals that epistasis can curb the evolution of antibiotic resistance
title_sort highly parallel lab evolution reveals that epistasis can curb the evolution of antibiotic resistance
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-06-01
description The antibiotic resistance crisis calls for new ways of restricting the ability of bacteria to evolve resistance. Here, Lukačišinová et al. perform highly controlled evolution experiments in E. coli strains to identify genetic perturbations that strongly limit the evolution of antibiotic resistance through epistasis.
url https://doi.org/10.1038/s41467-020-16932-z
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AT booshinifernando highlyparallellabevolutionrevealsthatepistasiscancurbtheevolutionofantibioticresistance
AT tobiasbollenbach highlyparallellabevolutionrevealsthatepistasiscancurbtheevolutionofantibioticresistance
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