RESULTS OF ALLOGENIC BONE MARROW TRANSPLANTATION IN CML IN IRAN

• Main Authors: A. khodabeh., P.Nasseri., M Jahani., A.Ghavamzadeh., I. Baybordi., M. Mohyeddin. G. Ghahremani
• Format: Article
• Language: English
• Published: Tehran University of Medical Sciences 1998-06-01
• Series: Acta Medica Iranica
• Subjects: Allogenic
• Online Access: https://acta.tums.ac.ir/index.php/acta/article/view/1742

Nineteen patterns with CML have been transplanted in our Bone Marrow Transplantation (BMT) section since 1991, The mean age of these patients was 26.05 (SD = 9.35). Our conditioning regimen for these patients was cyclophosphamide 60mglkg for 2 days and busulfan 4mglkg for 4 consecutive days. Eleven patients are still alive arid eight patients died during follow-up ranging from 6 months to 5 years. This review revealed a poor outcome for patients older than 30. There was also a rise in the mortality rate when the interval between diagnosis and BMT was longer than 2 years. In contrast with some previous reports, we found no relationship between spleen size in the pre-transplant period and BMT outcome, however recurrence of CM L after BMT correlates strongly with spleen size (P 1000/ml, PMN > 5001ml. PLT > 1000001ml) correlates directly with spleen size as well (P