Role of Site-Specific Glycosylation in the I-Like Domain of Integrin β1 in Small Extracellular Vesicle-Mediated Malignant Behavior and FAK Activation

Role of Site-Specific Glycosylation in the I-Like Domain of Integrin β1 in Small Extracellular Vesicle-Mediated Malignant Behavior and FAK Activation

Integrin β1 plays an essential role in the crosstalk between tumor cells and their microenvironment. Aberrant N-glycosylation of integrin β1 was documented to alter integrin β1 expression, dimerization, and biological function. However, the biological function of site-specific N-glycosylation of int...

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Bibliographic Details
Main Authors: Lin Cao, Yurong Wu, Xiuxiu Wang, Xiang Li, Zengqi Tan, Feng Guan
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
integrin β1
N-glycosylation
sEVs
FAK
migration
adhesion
Online Access:https://www.mdpi.com/1422-0067/22/4/1770

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