Signal-Dependent Recruitment of BRD4 to Cardiomyocyte Super-Enhancers Is Suppressed by a MicroRNA

Signal-Dependent Recruitment of BRD4 to Cardiomyocyte Super-Enhancers Is Suppressed by a MicroRNA

BRD4 governs pathological cardiac gene expression by binding acetylated chromatin, resulting in enhanced RNA polymerase II (Pol II) phosphorylation and transcription elongation. Here, we describe a signal-dependent mechanism for the regulation of BRD4 in cardiomyocytes. BRD4 expression is suppressed...

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Bibliographic Details
Main Authors: Matthew S. Stratton, Charles Y. Lin, Priti Anand, Philip D. Tatman, Bradley S. Ferguson, Sean T. Wickers, Amrut V. Ambardekar, Carmen C. Sucharov, James E. Bradner, Saptarsi M. Haldar, Timothy A. McKinsey
Format: Article
Language:English
Published: Elsevier 2016-08-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716308439

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