Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity
Heterogeneity within tumors presents a challenge to cancer treatment. Here, the authors investigate transcriptional heterogeneity in prostate cancer, examining expression profiles of different tissue components and highlighting expression gradients in the tumor microenvironment.
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Nature Publishing Group
2018-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-04724-5 |
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doaj-df809a2fbbdf48cfa7dfe5406664fb322021-05-11T10:07:17ZengNature Publishing GroupNature Communications2041-17232018-06-019111310.1038/s41467-018-04724-5Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneityEmelie Berglund0Jonas Maaskola1Niklas Schultz2Stefanie Friedrich3Maja Marklund4Joseph Bergenstråhle5Firas Tarish6Anna Tanoglidi7Sanja Vickovic8Ludvig Larsson9Fredrik Salmén10Christoph Ogris11Karolina Wallenborg12Jens Lagergren13Patrik Ståhl14Erik Sonnhammer15Thomas Helleday16Joakim Lundeberg17Department of Gene Technology, School of Engineering Sciences in Chemistry, Biotechnology and Health, Royal Institute of Technology (KTH), Science for Life LaboratoryDepartment of Gene Technology, School of Engineering Sciences in Chemistry, Biotechnology and Health, Royal Institute of Technology (KTH), Science for Life LaboratoryDepartment of Oncology-Pathology, Karolinska Institutet (KI), Science for Life LaboratoryDepartment of Biochemistry and Biophysics, Stockholm University, Science for Life LaboratoryDepartment of Gene Technology, School of Engineering Sciences in Chemistry, Biotechnology and Health, Royal Institute of Technology (KTH), Science for Life LaboratoryDepartment of Gene Technology, School of Engineering Sciences in Chemistry, Biotechnology and Health, Royal Institute of Technology (KTH), Science for Life LaboratoryDepartment of Oncology-Pathology, Karolinska Institutet (KI), Science for Life LaboratoryDepartment of Clinical Pathology, University Uppsala HospitalDepartment of Gene Technology, School of Engineering Sciences in Chemistry, Biotechnology and Health, Royal Institute of Technology (KTH), Science for Life LaboratoryDepartment of Gene Technology, School of Engineering Sciences in Chemistry, Biotechnology and Health, Royal Institute of Technology (KTH), Science for Life LaboratoryDepartment of Gene Technology, School of Engineering Sciences in Chemistry, Biotechnology and Health, Royal Institute of Technology (KTH), Science for Life LaboratoryDepartment of Biochemistry and Biophysics, Stockholm University, Science for Life LaboratoryDepartment of Oncology-Pathology, Karolinska Institutet (KI), Science for Life LaboratoryDepartment of Computational Biology, School of Computer Science and Communication, Royal Institute of Technology (KTH), Science for Life LaboratoryDepartment of Gene Technology, School of Engineering Sciences in Chemistry, Biotechnology and Health, Royal Institute of Technology (KTH), Science for Life LaboratoryDepartment of Biochemistry and Biophysics, Stockholm University, Science for Life LaboratoryDepartment of Oncology-Pathology, Karolinska Institutet (KI), Science for Life LaboratoryDepartment of Gene Technology, School of Engineering Sciences in Chemistry, Biotechnology and Health, Royal Institute of Technology (KTH), Science for Life LaboratoryHeterogeneity within tumors presents a challenge to cancer treatment. Here, the authors investigate transcriptional heterogeneity in prostate cancer, examining expression profiles of different tissue components and highlighting expression gradients in the tumor microenvironment.https://doi.org/10.1038/s41467-018-04724-5 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Emelie Berglund Jonas Maaskola Niklas Schultz Stefanie Friedrich Maja Marklund Joseph Bergenstråhle Firas Tarish Anna Tanoglidi Sanja Vickovic Ludvig Larsson Fredrik Salmén Christoph Ogris Karolina Wallenborg Jens Lagergren Patrik Ståhl Erik Sonnhammer Thomas Helleday Joakim Lundeberg |
| spellingShingle |
Emelie Berglund Jonas Maaskola Niklas Schultz Stefanie Friedrich Maja Marklund Joseph Bergenstråhle Firas Tarish Anna Tanoglidi Sanja Vickovic Ludvig Larsson Fredrik Salmén Christoph Ogris Karolina Wallenborg Jens Lagergren Patrik Ståhl Erik Sonnhammer Thomas Helleday Joakim Lundeberg Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity Nature Communications |
| author_facet |
Emelie Berglund Jonas Maaskola Niklas Schultz Stefanie Friedrich Maja Marklund Joseph Bergenstråhle Firas Tarish Anna Tanoglidi Sanja Vickovic Ludvig Larsson Fredrik Salmén Christoph Ogris Karolina Wallenborg Jens Lagergren Patrik Ståhl Erik Sonnhammer Thomas Helleday Joakim Lundeberg |
| author_sort |
Emelie Berglund |
| title |
Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity |
| title_short |
Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity |
| title_full |
Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity |
| title_fullStr |
Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity |
| title_full_unstemmed |
Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity |
| title_sort |
spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-06-01 |
| description |
Heterogeneity within tumors presents a challenge to cancer treatment. Here, the authors investigate transcriptional heterogeneity in prostate cancer, examining expression profiles of different tissue components and highlighting expression gradients in the tumor microenvironment. |
| url |
https://doi.org/10.1038/s41467-018-04724-5 |
| work_keys_str_mv |
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| _version_ |
1721448776827142144 |