Evolution and regulation of nitrogen flux through compartmentalized metabolic networks in a marine diatom
Here, using the diatom Phaeodactylum tricornutum as a model organism, the authors combine functional genomics, phylogenetics, and metabolic modeling to describe how diatoms might have functionally integrated nitrogen metabolism during evolution and how metabolic flux is regulated across cellular com...
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2019-10-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-12407-y |
| id |
doaj-df8bdef394aa4d558203fcc3850cecce |
|---|---|
| record_format |
Article |
| spelling |
doaj-df8bdef394aa4d558203fcc3850cecce2021-05-11T11:37:35ZengNature Publishing GroupNature Communications2041-17232019-10-0110111410.1038/s41467-019-12407-yEvolution and regulation of nitrogen flux through compartmentalized metabolic networks in a marine diatomSarah R. Smith0Chris L. Dupont1James K. McCarthy2Jared T. Broddrick3Miroslav Oborník4Aleš Horák5Zoltán Füssy6Jaromír Cihlář7Sabrina Kleessen8Hong Zheng9John P. McCrow10Kim K. Hixson11Wagner L. Araújo12Adriano Nunes-Nesi13Alisdair Fernie14Zoran Nikoloski15Bernhard O. Palsson16Andrew E. Allen17Microbial and Environmental Genomics, J. Craig Venter InstituteMicrobial and Environmental Genomics, J. Craig Venter InstituteMicrobial and Environmental Genomics, J. Craig Venter InstituteDivision of Biological Sciences, University of California, San DiegoInstitute of Parasitology, Biology Centre Czech Academy of SciencesInstitute of Parasitology, Biology Centre Czech Academy of SciencesInstitute of Parasitology, Biology Centre Czech Academy of SciencesInstitute of Parasitology, Biology Centre Czech Academy of SciencesTargenomix, GmbHMicrobial and Environmental Genomics, J. Craig Venter InstituteMicrobial and Environmental Genomics, J. Craig Venter InstituteEnvironmental Molecular Sciences Laboratory, Pacific Northwest National LaboratoryDepartamento de Biologia Vegetal, Universidade Federal de ViçosaDepartamento de Biologia Vegetal, Universidade Federal de ViçosaMax Planck Institut of Molecular Plant PhysiologyInstitute of Biochemistry and Biology, University of PotsdamDepartment of Bioengineering, University of California, San DiegoMicrobial and Environmental Genomics, J. Craig Venter InstituteHere, using the diatom Phaeodactylum tricornutum as a model organism, the authors combine functional genomics, phylogenetics, and metabolic modeling to describe how diatoms might have functionally integrated nitrogen metabolism during evolution and how metabolic flux is regulated across cellular compartmentshttps://doi.org/10.1038/s41467-019-12407-y |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Sarah R. Smith Chris L. Dupont James K. McCarthy Jared T. Broddrick Miroslav Oborník Aleš Horák Zoltán Füssy Jaromír Cihlář Sabrina Kleessen Hong Zheng John P. McCrow Kim K. Hixson Wagner L. Araújo Adriano Nunes-Nesi Alisdair Fernie Zoran Nikoloski Bernhard O. Palsson Andrew E. Allen |
| spellingShingle |
Sarah R. Smith Chris L. Dupont James K. McCarthy Jared T. Broddrick Miroslav Oborník Aleš Horák Zoltán Füssy Jaromír Cihlář Sabrina Kleessen Hong Zheng John P. McCrow Kim K. Hixson Wagner L. Araújo Adriano Nunes-Nesi Alisdair Fernie Zoran Nikoloski Bernhard O. Palsson Andrew E. Allen Evolution and regulation of nitrogen flux through compartmentalized metabolic networks in a marine diatom Nature Communications |
| author_facet |
Sarah R. Smith Chris L. Dupont James K. McCarthy Jared T. Broddrick Miroslav Oborník Aleš Horák Zoltán Füssy Jaromír Cihlář Sabrina Kleessen Hong Zheng John P. McCrow Kim K. Hixson Wagner L. Araújo Adriano Nunes-Nesi Alisdair Fernie Zoran Nikoloski Bernhard O. Palsson Andrew E. Allen |
| author_sort |
Sarah R. Smith |
| title |
Evolution and regulation of nitrogen flux through compartmentalized metabolic networks in a marine diatom |
| title_short |
Evolution and regulation of nitrogen flux through compartmentalized metabolic networks in a marine diatom |
| title_full |
Evolution and regulation of nitrogen flux through compartmentalized metabolic networks in a marine diatom |
| title_fullStr |
Evolution and regulation of nitrogen flux through compartmentalized metabolic networks in a marine diatom |
| title_full_unstemmed |
Evolution and regulation of nitrogen flux through compartmentalized metabolic networks in a marine diatom |
| title_sort |
evolution and regulation of nitrogen flux through compartmentalized metabolic networks in a marine diatom |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-10-01 |
| description |
Here, using the diatom Phaeodactylum tricornutum as a model organism, the authors combine functional genomics, phylogenetics, and metabolic modeling to describe how diatoms might have functionally integrated nitrogen metabolism during evolution and how metabolic flux is regulated across cellular compartments |
| url |
https://doi.org/10.1038/s41467-019-12407-y |
| work_keys_str_mv |
AT sarahrsmith evolutionandregulationofnitrogenfluxthroughcompartmentalizedmetabolicnetworksinamarinediatom AT chrisldupont evolutionandregulationofnitrogenfluxthroughcompartmentalizedmetabolicnetworksinamarinediatom AT jameskmccarthy evolutionandregulationofnitrogenfluxthroughcompartmentalizedmetabolicnetworksinamarinediatom AT jaredtbroddrick evolutionandregulationofnitrogenfluxthroughcompartmentalizedmetabolicnetworksinamarinediatom AT miroslavobornik evolutionandregulationofnitrogenfluxthroughcompartmentalizedmetabolicnetworksinamarinediatom AT aleshorak evolutionandregulationofnitrogenfluxthroughcompartmentalizedmetabolicnetworksinamarinediatom AT zoltanfussy evolutionandregulationofnitrogenfluxthroughcompartmentalizedmetabolicnetworksinamarinediatom AT jaromircihlar evolutionandregulationofnitrogenfluxthroughcompartmentalizedmetabolicnetworksinamarinediatom AT sabrinakleessen evolutionandregulationofnitrogenfluxthroughcompartmentalizedmetabolicnetworksinamarinediatom AT hongzheng evolutionandregulationofnitrogenfluxthroughcompartmentalizedmetabolicnetworksinamarinediatom AT johnpmccrow evolutionandregulationofnitrogenfluxthroughcompartmentalizedmetabolicnetworksinamarinediatom AT kimkhixson evolutionandregulationofnitrogenfluxthroughcompartmentalizedmetabolicnetworksinamarinediatom AT wagnerlaraujo evolutionandregulationofnitrogenfluxthroughcompartmentalizedmetabolicnetworksinamarinediatom AT adrianonunesnesi evolutionandregulationofnitrogenfluxthroughcompartmentalizedmetabolicnetworksinamarinediatom AT alisdairfernie evolutionandregulationofnitrogenfluxthroughcompartmentalizedmetabolicnetworksinamarinediatom AT zorannikoloski evolutionandregulationofnitrogenfluxthroughcompartmentalizedmetabolicnetworksinamarinediatom AT bernhardopalsson evolutionandregulationofnitrogenfluxthroughcompartmentalizedmetabolicnetworksinamarinediatom AT andreweallen evolutionandregulationofnitrogenfluxthroughcompartmentalizedmetabolicnetworksinamarinediatom |
| _version_ |
1721446242001616896 |