The Role of Mesenchymal Stem Cells in Atherosclerosis: Prospects for Therapy via the Modulation of Inflammatory Milieu
Atherosclerosis is a chronic, inflammatory disease that mainly affects the arterial intima. The disease is more prevalent in middle-age and older individuals with one or more cardiovascular risk factors, including dyslipidemia, hypertension, diabetes, smoking, obesity, and others. The beginning and...
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doaj-df930ee5d5ff43fcab52326037e3d27b2020-11-25T01:17:15ZengMDPI AGJournal of Clinical Medicine2077-03832019-09-0189141310.3390/jcm8091413jcm8091413The Role of Mesenchymal Stem Cells in Atherosclerosis: Prospects for Therapy via the Modulation of Inflammatory MilieuArmita Mahdavi Gorabi0Maciej Banach1Željko Reiner2Matteo Pirro3Saeideh Hajighasemi4Thomas P. Johnston5Amirhossein Sahebkar6Department of Basic and Clinical Research, Tehran Heart Center, Tehran University of Medical Sciences, Tehran 1411713138, IranDepartment of Hypertension, WAM University Hospital in Lodz, Medical University of Lodz, Zeromskiego 113, 90-549 Lodz, PolandDepartment of Internal medicine, University Hospital Center Zagreb, Kišpatićeva 12, Zagreb 1000, CroatiaUnit of Internal Medicine, Angiology and Arteriosclerosis Diseases, Department of Medicine, University of Perugia, 06123 Perugia, ItalyDepartment of Medical Biotechnology, Faculty of Paramedicine, Qazvin University of Medical Sciences, Qazvin 1531534199, IranDivision of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO 64110, USABiotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad 91778-99191, IranAtherosclerosis is a chronic, inflammatory disease that mainly affects the arterial intima. The disease is more prevalent in middle-age and older individuals with one or more cardiovascular risk factors, including dyslipidemia, hypertension, diabetes, smoking, obesity, and others. The beginning and development of atherosclerosis has been associated with several immune components, including infiltration of inflammatory cells, monocyte/macrophage-derived foam cells, and inflammatory cytokines and chemokines. Mesenchymal stem cells (MSCs) originate from several tissue sources of the body and have self-renewal and multipotent differentiation characteristics. They also have immunomodulatory and anti-inflammatory properties. Recently, it was shown that MSCs have a regulatory role in plasma lipid levels. In addition, MSCs have shown to have promising potential in terms of treatment strategies for several diseases, including those with an inflammatory component. In this regard, transplantation of MSCs to patients with atherosclerosis has been proposed as a novel strategy in the treatment of this disease. In this review, we summarize the current advancements regarding MSCs for the treatment of atherosclerosis.https://www.mdpi.com/2077-0383/8/9/1413atherosclerosismesenchymal stem cellsinflammationcytokinestherapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Armita Mahdavi Gorabi Maciej Banach Željko Reiner Matteo Pirro Saeideh Hajighasemi Thomas P. Johnston Amirhossein Sahebkar |
spellingShingle |
Armita Mahdavi Gorabi Maciej Banach Željko Reiner Matteo Pirro Saeideh Hajighasemi Thomas P. Johnston Amirhossein Sahebkar The Role of Mesenchymal Stem Cells in Atherosclerosis: Prospects for Therapy via the Modulation of Inflammatory Milieu Journal of Clinical Medicine atherosclerosis mesenchymal stem cells inflammation cytokines therapy |
author_facet |
Armita Mahdavi Gorabi Maciej Banach Željko Reiner Matteo Pirro Saeideh Hajighasemi Thomas P. Johnston Amirhossein Sahebkar |
author_sort |
Armita Mahdavi Gorabi |
title |
The Role of Mesenchymal Stem Cells in Atherosclerosis: Prospects for Therapy via the Modulation of Inflammatory Milieu |
title_short |
The Role of Mesenchymal Stem Cells in Atherosclerosis: Prospects for Therapy via the Modulation of Inflammatory Milieu |
title_full |
The Role of Mesenchymal Stem Cells in Atherosclerosis: Prospects for Therapy via the Modulation of Inflammatory Milieu |
title_fullStr |
The Role of Mesenchymal Stem Cells in Atherosclerosis: Prospects for Therapy via the Modulation of Inflammatory Milieu |
title_full_unstemmed |
The Role of Mesenchymal Stem Cells in Atherosclerosis: Prospects for Therapy via the Modulation of Inflammatory Milieu |
title_sort |
role of mesenchymal stem cells in atherosclerosis: prospects for therapy via the modulation of inflammatory milieu |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2019-09-01 |
description |
Atherosclerosis is a chronic, inflammatory disease that mainly affects the arterial intima. The disease is more prevalent in middle-age and older individuals with one or more cardiovascular risk factors, including dyslipidemia, hypertension, diabetes, smoking, obesity, and others. The beginning and development of atherosclerosis has been associated with several immune components, including infiltration of inflammatory cells, monocyte/macrophage-derived foam cells, and inflammatory cytokines and chemokines. Mesenchymal stem cells (MSCs) originate from several tissue sources of the body and have self-renewal and multipotent differentiation characteristics. They also have immunomodulatory and anti-inflammatory properties. Recently, it was shown that MSCs have a regulatory role in plasma lipid levels. In addition, MSCs have shown to have promising potential in terms of treatment strategies for several diseases, including those with an inflammatory component. In this regard, transplantation of MSCs to patients with atherosclerosis has been proposed as a novel strategy in the treatment of this disease. In this review, we summarize the current advancements regarding MSCs for the treatment of atherosclerosis. |
topic |
atherosclerosis mesenchymal stem cells inflammation cytokines therapy |
url |
https://www.mdpi.com/2077-0383/8/9/1413 |
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