HLA-B*13 :01 Is a Predictive Marker of Dapsone-Induced Severe Cutaneous Adverse Reactions in Thai Patients

HLA-B*13 :01 Is a Predictive Marker of Dapsone-Induced Severe Cutaneous Adverse Reactions in Thai Patients

HLA-B*13:01 allele has been identified as the genetic determinant of dapsone hypersensitivity syndrome (DHS) among leprosy and non-leprosy patients in several studies. Dapsone hydroxylamine (DDS-NHOH), an active metabolite of dapsone, has been believed to be responsible for DHS. However, studies hav...

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Main Authors: Patompong Satapornpong, Jirawat Pratoomwun, Pawinee Rerknimitr, Jettanong Klaewsongkram, Nontaya Nakkam, Thanyada Rungrotmongkol, Parinya Konyoung, Niwat Saksit, Ajanee Mahakkanukrauh, Warayuwadee Amornpinyo, Usanee Khunarkornsiri, Therdpong Tempark, Kittipong Wantavornprasert, Pimonpan Jinda, Napatrupron Koomdee, Thawinee Jantararoungtong, Ticha Rerkpattanapipat, Chuang-Wei Wang, Dean Naisbitt, Wichittra Tassaneeyakul, Manasalak Ariyachaipanich, Thapana Roonghiranwat, Munir Pirmohamed, Wen-Hung Chung, Chonlaphat Sukasem
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
dapsone-induced severe cutaneous adverse reactions
HLA class I and II alleles
HLA-B*13:01
cytochrome P450
Thais and Taiwaneses
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.661135/full

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