Serological Protection 5–6 Years Post Vaccination Against Yellow Fever in African Infants Vaccinated in Routine Programmes
Introduction: Although effective live attenuated yellow fever (YF) vaccines have been available for over 9 decades sporadic outbreaks continue to occur in endemic regions. These may be linked to several factors including epidemiological factors such as vector and intermediate host distribution or va...
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doaj-dfc6d809734849388d2e079616b59a152020-11-25T03:51:56ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-10-011110.3389/fimmu.2020.577751577751Serological Protection 5–6 Years Post Vaccination Against Yellow Fever in African Infants Vaccinated in Routine ProgrammesOlubukola T. Idoko0Olubukola T. Idoko1Cristina Domingo2Milagritos D. Tapia3Samba O. Sow4Christof Geldmacher5Christof Geldmacher6Elmar Saathoff7Elmar Saathoff8Beate Kampmann9Beate Kampmann10Vaccines and Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, GambiaCIHLMU Center for International Health, Medical Center of the University of Munich (Ludwig-Maximilians-Universität München), Munich, GermanyCentre for Biological Threats and Special Pathogens, Robert Koch Institute, Berlin, GermanyCentre pour le Développement des Vaccins, University of Maryland, Bamako, MaliCentre pour le Développement des Vaccins, University of Maryland, Bamako, MaliDivision of Infectious Diseases and Tropical Medicine, University Hospital, Ludwig-Maximilians-Universität München Munich, Munich, GermanyGerman Centre for Infection Research (Deutsches Zentrum für Infektionsforschung), Munich, GermanyDivision of Infectious Diseases and Tropical Medicine, University Hospital, Ludwig-Maximilians-Universität München Munich, Munich, GermanyGerman Centre for Infection Research (Deutsches Zentrum für Infektionsforschung), Munich, GermanyVaccines and Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, GambiaThe Vaccine Centre, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United KingdomIntroduction: Although effective live attenuated yellow fever (YF) vaccines have been available for over 9 decades sporadic outbreaks continue to occur in endemic regions. These may be linked to several factors including epidemiological factors such as vector and intermediate host distribution or vaccine coverage and efficacy. The World Health Organization's research priorities include gathering systematic evidence around the potential need for booster vaccination with YF vaccine whether this follows full or fractional doses in children. Knowledge on the longevity of response to YF vaccine and the implications of this response needs to be consolidated to guide future vaccination policy.Methods: We measured anti-YF IgG by microneutralization assay in a group of 481 African infants who had received YF vaccine as part of routine EPI programmes, to explore serological protection from YF 5–6 years post YF vaccination, as well as the effect of co variates.Findings: Notably, 22.2% of the cohort had undetectable antibody concentrations, with another 7.5% revealing concentrations below the threshold of seropositivity of 0.5 IU/mL. Sex, season, country and time since vaccination did not affect the longevity of antibody concentration or having antibody concentrations above a defined threshold.Conclusion: Roughly 30% of children in this cohort did not demonstrate anti-yellow fever antibody concentrations above the defined threshold of protection, with 20% having no demonstrable antibody. Knowledge on the longevity of response to YF vaccine and the implications needs to be consolidated to guide future vaccination policy.https://www.frontiersin.org/article/10.3389/fimmu.2020.577751/fullserologicprotection5-6 years post vaccinationyellow feverroutine immunizations |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Olubukola T. Idoko Olubukola T. Idoko Cristina Domingo Milagritos D. Tapia Samba O. Sow Christof Geldmacher Christof Geldmacher Elmar Saathoff Elmar Saathoff Beate Kampmann Beate Kampmann |
spellingShingle |
Olubukola T. Idoko Olubukola T. Idoko Cristina Domingo Milagritos D. Tapia Samba O. Sow Christof Geldmacher Christof Geldmacher Elmar Saathoff Elmar Saathoff Beate Kampmann Beate Kampmann Serological Protection 5–6 Years Post Vaccination Against Yellow Fever in African Infants Vaccinated in Routine Programmes Frontiers in Immunology serologic protection 5-6 years post vaccination yellow fever routine immunizations |
author_facet |
Olubukola T. Idoko Olubukola T. Idoko Cristina Domingo Milagritos D. Tapia Samba O. Sow Christof Geldmacher Christof Geldmacher Elmar Saathoff Elmar Saathoff Beate Kampmann Beate Kampmann |
author_sort |
Olubukola T. Idoko |
title |
Serological Protection 5–6 Years Post Vaccination Against Yellow Fever in African Infants Vaccinated in Routine Programmes |
title_short |
Serological Protection 5–6 Years Post Vaccination Against Yellow Fever in African Infants Vaccinated in Routine Programmes |
title_full |
Serological Protection 5–6 Years Post Vaccination Against Yellow Fever in African Infants Vaccinated in Routine Programmes |
title_fullStr |
Serological Protection 5–6 Years Post Vaccination Against Yellow Fever in African Infants Vaccinated in Routine Programmes |
title_full_unstemmed |
Serological Protection 5–6 Years Post Vaccination Against Yellow Fever in African Infants Vaccinated in Routine Programmes |
title_sort |
serological protection 5–6 years post vaccination against yellow fever in african infants vaccinated in routine programmes |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2020-10-01 |
description |
Introduction: Although effective live attenuated yellow fever (YF) vaccines have been available for over 9 decades sporadic outbreaks continue to occur in endemic regions. These may be linked to several factors including epidemiological factors such as vector and intermediate host distribution or vaccine coverage and efficacy. The World Health Organization's research priorities include gathering systematic evidence around the potential need for booster vaccination with YF vaccine whether this follows full or fractional doses in children. Knowledge on the longevity of response to YF vaccine and the implications of this response needs to be consolidated to guide future vaccination policy.Methods: We measured anti-YF IgG by microneutralization assay in a group of 481 African infants who had received YF vaccine as part of routine EPI programmes, to explore serological protection from YF 5–6 years post YF vaccination, as well as the effect of co variates.Findings: Notably, 22.2% of the cohort had undetectable antibody concentrations, with another 7.5% revealing concentrations below the threshold of seropositivity of 0.5 IU/mL. Sex, season, country and time since vaccination did not affect the longevity of antibody concentration or having antibody concentrations above a defined threshold.Conclusion: Roughly 30% of children in this cohort did not demonstrate anti-yellow fever antibody concentrations above the defined threshold of protection, with 20% having no demonstrable antibody. Knowledge on the longevity of response to YF vaccine and the implications needs to be consolidated to guide future vaccination policy. |
topic |
serologic protection 5-6 years post vaccination yellow fever routine immunizations |
url |
https://www.frontiersin.org/article/10.3389/fimmu.2020.577751/full |
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