Ruyiping extract reduces lung metastasis in triple negative breast cancer by regulating macrophage polarization
Lung metastasis of Triple-negative breast cancer (TNBC) causes severe breath-related events and poor prognosis. Ruyiping (RYP), a traditional Chinese medicine prescription, is used to treat breast cancer lung metastasis in clinical practice. This study was to explore the anti-lung-metastatic activit...
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2021-09-01
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doaj-dfceef2b11b9411bbd19a7e6dea9de9f2021-09-05T04:39:04ZengElsevierBiomedicine & Pharmacotherapy0753-33222021-09-01141111883Ruyiping extract reduces lung metastasis in triple negative breast cancer by regulating macrophage polarizationRui Yang0Ying Xie1Qiong Li2Yiyi Ye3Youyang Shi4Xiangdong Zhao5Chunyu Wu6Yiyun Xu7Rui Wang8Yang Zhang9Xiaojuan Yang10Xianghui Han11Sheng Liu12Institute of Chinese Traditional Surgery, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, ChinaInstitute of Chinese Traditional Surgery, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, ChinaDepartment of Breast Surgery, Yueyang Hospital of Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200000, ChinaInstitute of Chinese Traditional Surgery, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, ChinaInstitute of Chinese Traditional Surgery, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, ChinaDepartment of Anus and Intestine Surgery, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518000, ChinaInstitute of Chinese Traditional Surgery, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, ChinaInstitute of Chinese Traditional Surgery, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, ChinaInstitute of Chinese Traditional Surgery, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, ChinaInstitute of Chinese Traditional Surgery, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, ChinaInstitute of Chinese Traditional Surgery, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, ChinaInstitute of Chinese Traditional Surgery, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China; Corresponding authors.Institute of Chinese Traditional Surgery, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China; Corresponding authors.Lung metastasis of Triple-negative breast cancer (TNBC) causes severe breath-related events and poor prognosis. Ruyiping (RYP), a traditional Chinese medicine prescription, is used to treat breast cancer lung metastasis in clinical practice. This study was to explore the anti-lung-metastatic activities and mechanism of RYP extract by regulating macrophage polarization. The results showed that RYP can inhibit the viability and induce the apoptosis of TNBC cells. In in vitro experiments, RYP significantly inhibited the invasion and migration ability of TNBC cells promoted by M2, the subtype of macrophage which increased TNBC metastasis related genes. In in vivo experiments, RYP reduced the TNBC progression and lung metastasis. M2/M1 ration in the lung and M2 in the tumor was reduced by RYP, as well as M2 master regulator Stat6. Therefore, RYP extract may exhibit anti-lung metastasis function by reducing M2 in both tumor and lung through reducing Stat6.http://www.sciencedirect.com/science/article/pii/S075333222100665XTriple negative breast cancerLung metastasisRuyiping extractMacrophage polarization |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rui Yang Ying Xie Qiong Li Yiyi Ye Youyang Shi Xiangdong Zhao Chunyu Wu Yiyun Xu Rui Wang Yang Zhang Xiaojuan Yang Xianghui Han Sheng Liu |
spellingShingle |
Rui Yang Ying Xie Qiong Li Yiyi Ye Youyang Shi Xiangdong Zhao Chunyu Wu Yiyun Xu Rui Wang Yang Zhang Xiaojuan Yang Xianghui Han Sheng Liu Ruyiping extract reduces lung metastasis in triple negative breast cancer by regulating macrophage polarization Biomedicine & Pharmacotherapy Triple negative breast cancer Lung metastasis Ruyiping extract Macrophage polarization |
author_facet |
Rui Yang Ying Xie Qiong Li Yiyi Ye Youyang Shi Xiangdong Zhao Chunyu Wu Yiyun Xu Rui Wang Yang Zhang Xiaojuan Yang Xianghui Han Sheng Liu |
author_sort |
Rui Yang |
title |
Ruyiping extract reduces lung metastasis in triple negative breast cancer by regulating macrophage polarization |
title_short |
Ruyiping extract reduces lung metastasis in triple negative breast cancer by regulating macrophage polarization |
title_full |
Ruyiping extract reduces lung metastasis in triple negative breast cancer by regulating macrophage polarization |
title_fullStr |
Ruyiping extract reduces lung metastasis in triple negative breast cancer by regulating macrophage polarization |
title_full_unstemmed |
Ruyiping extract reduces lung metastasis in triple negative breast cancer by regulating macrophage polarization |
title_sort |
ruyiping extract reduces lung metastasis in triple negative breast cancer by regulating macrophage polarization |
publisher |
Elsevier |
series |
Biomedicine & Pharmacotherapy |
issn |
0753-3322 |
publishDate |
2021-09-01 |
description |
Lung metastasis of Triple-negative breast cancer (TNBC) causes severe breath-related events and poor prognosis. Ruyiping (RYP), a traditional Chinese medicine prescription, is used to treat breast cancer lung metastasis in clinical practice. This study was to explore the anti-lung-metastatic activities and mechanism of RYP extract by regulating macrophage polarization. The results showed that RYP can inhibit the viability and induce the apoptosis of TNBC cells. In in vitro experiments, RYP significantly inhibited the invasion and migration ability of TNBC cells promoted by M2, the subtype of macrophage which increased TNBC metastasis related genes. In in vivo experiments, RYP reduced the TNBC progression and lung metastasis. M2/M1 ration in the lung and M2 in the tumor was reduced by RYP, as well as M2 master regulator Stat6. Therefore, RYP extract may exhibit anti-lung metastasis function by reducing M2 in both tumor and lung through reducing Stat6. |
topic |
Triple negative breast cancer Lung metastasis Ruyiping extract Macrophage polarization |
url |
http://www.sciencedirect.com/science/article/pii/S075333222100665X |
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