Circulating levels of mitochondrial uncoupling protein 2, but not prohibitin, are lower in humans with type 2 diabetes and correlate with brachial artery flow-mediated dilation

Circulating levels of mitochondrial uncoupling protein 2, but not prohibitin, are lower in humans with type 2 diabetes and correlate with brachial artery flow-mediated dilation

Abstract Background Excessive reactive oxygen species from endothelial mitochondria in type 2 diabetes individuals (T2DM) may occur through multiple related mechanisms, including production of mitochondrial reactive oxygen species (mtROS), inner mitochondrial membrane (Δψm) hyperpolarization, change...

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Bibliographic Details
Main Authors: Mamatha Kakarla, Venkata K. Puppala, Sudhi Tyagi, Amberly Anger, Kathryn Repp, Jingli Wang, Rong Ying, Michael E. Widlansky
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Cardiovascular Diabetology
Subjects:
Mitochondria
Endothelium
Mitochondrial membrane potential
UCP2
PHB
Online Access:http://link.springer.com/article/10.1186/s12933-019-0956-4

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