TbD1 deletion as a driver of the evolutionary success of modern epidemic Mycobacterium tuberculosis lineages
Mycobacterium tuberculosis (Mtb) modern strains emerged from a common progenitor after the loss of Mtb-specific deletion 1 region (TbD1). Here, the authors show that deletion of TbD1 correlates with enhanced Mtb virulence in animal models, mirroring the development of hypoxic granulomas in human dis...
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Nature Publishing Group
2020-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-14508-5 |
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doaj-dfe06d57f9b145fda733b5868dbc18ce2021-05-11T08:34:11ZengNature Publishing GroupNature Communications2041-17232020-02-0111111410.1038/s41467-020-14508-5TbD1 deletion as a driver of the evolutionary success of modern epidemic Mycobacterium tuberculosis lineagesDaria Bottai0Wafa Frigui1Fadel Sayes2Mariagrazia Di Luca3Dalila Spadoni4Alexandre Pawlik5Marina Zoppo6Mickael Orgeur7Varun Khanna8David Hardy9Sophie Mangenot10Valerie Barbe11Claudine Medigue12Laurence Ma13Christiane Bouchier14Arianna Tavanti15Gerald Larrouy-Maumus16Roland Brosch17Department of Biology, University of PisaInstitut Pasteur, Unit for Integrated Mycobacterial PathogenomicsInstitut Pasteur, Unit for Integrated Mycobacterial PathogenomicsDepartment of Biology, University of PisaDepartment of Biology, University of PisaInstitut Pasteur, Unit for Integrated Mycobacterial PathogenomicsDepartment of Biology, University of PisaInstitut Pasteur, Unit for Integrated Mycobacterial PathogenomicsInstitut Pasteur, Unit for Integrated Mycobacterial PathogenomicsInstitut Pasteur, Experimental Neuropathology UnitGénomique Métabolique, Genoscope, Institut de biologie François Jacob, Commissariat à l’Energie Atomique (CEA), CNRS, Université Evry, Université Paris-SaclayGénomique Métabolique, Genoscope, Institut de biologie François Jacob, Commissariat à l’Energie Atomique (CEA), CNRS, Université Evry, Université Paris-SaclayLABGeM, Génomique Métabolique, Genoscope, Institut François Jacob, CEA, CNRS, Univ Evry, Université Paris-SaclayInstitut Pasteur, Plate-forme génomique, Pasteur Genopole Ile de FranceInstitut Pasteur, Plate-forme génomique, Pasteur Genopole Ile de FranceDepartment of Biology, University of PisaMRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Faculty of Natural Sciences, Imperial College LondonInstitut Pasteur, Unit for Integrated Mycobacterial PathogenomicsMycobacterium tuberculosis (Mtb) modern strains emerged from a common progenitor after the loss of Mtb-specific deletion 1 region (TbD1). Here, the authors show that deletion of TbD1 correlates with enhanced Mtb virulence in animal models, mirroring the development of hypoxic granulomas in human disease progression.https://doi.org/10.1038/s41467-020-14508-5 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Daria Bottai Wafa Frigui Fadel Sayes Mariagrazia Di Luca Dalila Spadoni Alexandre Pawlik Marina Zoppo Mickael Orgeur Varun Khanna David Hardy Sophie Mangenot Valerie Barbe Claudine Medigue Laurence Ma Christiane Bouchier Arianna Tavanti Gerald Larrouy-Maumus Roland Brosch |
| spellingShingle |
Daria Bottai Wafa Frigui Fadel Sayes Mariagrazia Di Luca Dalila Spadoni Alexandre Pawlik Marina Zoppo Mickael Orgeur Varun Khanna David Hardy Sophie Mangenot Valerie Barbe Claudine Medigue Laurence Ma Christiane Bouchier Arianna Tavanti Gerald Larrouy-Maumus Roland Brosch TbD1 deletion as a driver of the evolutionary success of modern epidemic Mycobacterium tuberculosis lineages Nature Communications |
| author_facet |
Daria Bottai Wafa Frigui Fadel Sayes Mariagrazia Di Luca Dalila Spadoni Alexandre Pawlik Marina Zoppo Mickael Orgeur Varun Khanna David Hardy Sophie Mangenot Valerie Barbe Claudine Medigue Laurence Ma Christiane Bouchier Arianna Tavanti Gerald Larrouy-Maumus Roland Brosch |
| author_sort |
Daria Bottai |
| title |
TbD1 deletion as a driver of the evolutionary success of modern epidemic Mycobacterium tuberculosis lineages |
| title_short |
TbD1 deletion as a driver of the evolutionary success of modern epidemic Mycobacterium tuberculosis lineages |
| title_full |
TbD1 deletion as a driver of the evolutionary success of modern epidemic Mycobacterium tuberculosis lineages |
| title_fullStr |
TbD1 deletion as a driver of the evolutionary success of modern epidemic Mycobacterium tuberculosis lineages |
| title_full_unstemmed |
TbD1 deletion as a driver of the evolutionary success of modern epidemic Mycobacterium tuberculosis lineages |
| title_sort |
tbd1 deletion as a driver of the evolutionary success of modern epidemic mycobacterium tuberculosis lineages |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-02-01 |
| description |
Mycobacterium tuberculosis (Mtb) modern strains emerged from a common progenitor after the loss of Mtb-specific deletion 1 region (TbD1). Here, the authors show that deletion of TbD1 correlates with enhanced Mtb virulence in animal models, mirroring the development of hypoxic granulomas in human disease progression. |
| url |
https://doi.org/10.1038/s41467-020-14508-5 |
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