Asystolic cardiac arrest following liposomal amphotericin B infusion: anaphylaxis or compliment activation-related pseudoallergy?

Asystolic cardiac arrest following liposomal amphotericin B infusion: anaphylaxis or compliment activation-related pseudoallergy?

Abstract Allergic reaction to liposomal amphotericin B is rare. We report a case of cardiac arrest in a 64-year-old woman following liposomal amphotericin B infusion, requiring resuscitation. We also present the results of subsequent skin prick and intradermal testing to liposomal amphotericin on th...

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Bibliographic Details
Main Authors: George P. Drewett, Ana Copaescu, Joseph DeLuca, Natasha E. Holmes, Jason A. Trubiano
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Allergy, Asthma & Clinical Immunology
Subjects:
Ambisome
LAmB
Skin prick testing
Intradermal testing
CARPA
Online Access:https://doi.org/10.1186/s13223-021-00582-x
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spelling doaj-dfe6426d81c242048d5648acd39022fc2021-08-01T11:41:06ZengBMCAllergy, Asthma & Clinical Immunology1710-14922021-07-011711510.1186/s13223-021-00582-xAsystolic cardiac arrest following liposomal amphotericin B infusion: anaphylaxis or compliment activation-related pseudoallergy?George P. Drewett0Ana Copaescu1Joseph DeLuca2Natasha E. Holmes3Jason A. Trubiano4Department of Infectious Diseases, Austin HealthDepartment of Drug and Antibiotic Allergy Services, Austin HealthDepartment of Drug and Antibiotic Allergy Services, Austin HealthDepartment of Infectious Diseases, Austin HealthDepartment of Infectious Diseases, Austin HealthAbstract Allergic reaction to liposomal amphotericin B is rare. We report a case of cardiac arrest in a 64-year-old woman following liposomal amphotericin B infusion, requiring resuscitation. We also present the results of subsequent skin prick and intradermal testing to liposomal amphotericin on the patient and three healthy controls, highlighting the need for further research into the immunopathogenesis of this reaction.https://doi.org/10.1186/s13223-021-00582-xAmbisomeLAmBSkin prick testingIntradermal testingCARPA
collection DOAJ
language English
format Article
sources DOAJ
author George P. Drewett
Ana Copaescu
Joseph DeLuca
Natasha E. Holmes
Jason A. Trubiano
spellingShingle George P. Drewett
Ana Copaescu
Joseph DeLuca
Natasha E. Holmes
Jason A. Trubiano
Asystolic cardiac arrest following liposomal amphotericin B infusion: anaphylaxis or compliment activation-related pseudoallergy?
Allergy, Asthma & Clinical Immunology
Ambisome
LAmB
Skin prick testing
Intradermal testing
CARPA
author_facet George P. Drewett
Ana Copaescu
Joseph DeLuca
Natasha E. Holmes
Jason A. Trubiano
author_sort George P. Drewett
title Asystolic cardiac arrest following liposomal amphotericin B infusion: anaphylaxis or compliment activation-related pseudoallergy?
title_short Asystolic cardiac arrest following liposomal amphotericin B infusion: anaphylaxis or compliment activation-related pseudoallergy?
title_full Asystolic cardiac arrest following liposomal amphotericin B infusion: anaphylaxis or compliment activation-related pseudoallergy?
title_fullStr Asystolic cardiac arrest following liposomal amphotericin B infusion: anaphylaxis or compliment activation-related pseudoallergy?
title_full_unstemmed Asystolic cardiac arrest following liposomal amphotericin B infusion: anaphylaxis or compliment activation-related pseudoallergy?
title_sort asystolic cardiac arrest following liposomal amphotericin b infusion: anaphylaxis or compliment activation-related pseudoallergy?
publisher BMC
series Allergy, Asthma & Clinical Immunology
issn 1710-1492
publishDate 2021-07-01
description Abstract Allergic reaction to liposomal amphotericin B is rare. We report a case of cardiac arrest in a 64-year-old woman following liposomal amphotericin B infusion, requiring resuscitation. We also present the results of subsequent skin prick and intradermal testing to liposomal amphotericin on the patient and three healthy controls, highlighting the need for further research into the immunopathogenesis of this reaction.
topic Ambisome
LAmB
Skin prick testing
Intradermal testing
CARPA
url https://doi.org/10.1186/s13223-021-00582-x
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AT anacopaescu asystoliccardiacarrestfollowingliposomalamphotericinbinfusionanaphylaxisorcomplimentactivationrelatedpseudoallergy
AT josephdeluca asystoliccardiacarrestfollowingliposomalamphotericinbinfusionanaphylaxisorcomplimentactivationrelatedpseudoallergy
AT natashaeholmes asystoliccardiacarrestfollowingliposomalamphotericinbinfusionanaphylaxisorcomplimentactivationrelatedpseudoallergy
AT jasonatrubiano asystoliccardiacarrestfollowingliposomalamphotericinbinfusionanaphylaxisorcomplimentactivationrelatedpseudoallergy
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