RELATED FACTORS FOR COLONIZATION BY Candida SPECIES IN THE ORAL CAVITY OF HIV-INFECTED INDIVIDUALS
The colonization of the oral cavity is a prerequisite to the development of oropharyngeal candidiasis. Aims: The aims of this study were: to evaluate colonization and quantify Candida spp. in the oral cavity; to determine the predisposing factors for colonization; and to correlate the levels of CD4...
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2015-10-01
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doaj-dfffee4bf60243cdb9b4c5700a788ff82020-11-25T02:35:03ZengUniversidade de São PauloRevista do Instituto de Medicina Tropical de São Paulo1678-99462015-10-0157541341910.1590/S0036-46652015000500008S0036-46652015000500413RELATED FACTORS FOR COLONIZATION BY Candida SPECIES IN THE ORAL CAVITY OF HIV-INFECTED INDIVIDUALSRalciane de Paula MENEZESAércio Sebastião BORGESLúcio Borges de ARAUJOReginaldo dos Santos PEDROSODenise Von Dolinger de Brito RÖDERThe colonization of the oral cavity is a prerequisite to the development of oropharyngeal candidiasis. Aims: The aims of this study were: to evaluate colonization and quantify Candida spp. in the oral cavity; to determine the predisposing factors for colonization; and to correlate the levels of CD4+ cells and viral load with the yeast count of colony forming units per milliliter (CFU/mL) in HIV-positive individuals treated at a University Hospital. Saliva samples were collected from 147 HIV patients and were plated on Sabouraud Dextrose Agar (SDA) and chromogenic agar, and incubated at 30 ºC for 72 h. Colonies with similar morphology in both media were counted and the result expressed in CFU/mL. Results: Of the 147 HIV patients, 89 had positive cultures for Candida spp., with a total of 111 isolates, of which C. albicans was the most frequent species (67.6%), and the mean of colonies counted was 8.8 × 10³ CFU/mL. The main predisposing factors for oral colonization by Candida spp. were the use of antibiotics and oral prostheses. The use of reverse transcriptase inhibitors appears to have a greater protective effect for colonization. A low CD4+ T lymphocyte count is associated with a higher density of yeast in the saliva of HIV patients.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652015000500413&lng=en&tlng=enCandida, HIVCandidiasisOralColonization |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ralciane de Paula MENEZES Aércio Sebastião BORGES Lúcio Borges de ARAUJO Reginaldo dos Santos PEDROSO Denise Von Dolinger de Brito RÖDER |
spellingShingle |
Ralciane de Paula MENEZES Aércio Sebastião BORGES Lúcio Borges de ARAUJO Reginaldo dos Santos PEDROSO Denise Von Dolinger de Brito RÖDER RELATED FACTORS FOR COLONIZATION BY Candida SPECIES IN THE ORAL CAVITY OF HIV-INFECTED INDIVIDUALS Revista do Instituto de Medicina Tropical de São Paulo Candida, HIV Candidiasis Oral Colonization |
author_facet |
Ralciane de Paula MENEZES Aércio Sebastião BORGES Lúcio Borges de ARAUJO Reginaldo dos Santos PEDROSO Denise Von Dolinger de Brito RÖDER |
author_sort |
Ralciane de Paula MENEZES |
title |
RELATED FACTORS FOR COLONIZATION BY Candida SPECIES IN THE ORAL CAVITY OF HIV-INFECTED INDIVIDUALS |
title_short |
RELATED FACTORS FOR COLONIZATION BY Candida SPECIES IN THE ORAL CAVITY OF HIV-INFECTED INDIVIDUALS |
title_full |
RELATED FACTORS FOR COLONIZATION BY Candida SPECIES IN THE ORAL CAVITY OF HIV-INFECTED INDIVIDUALS |
title_fullStr |
RELATED FACTORS FOR COLONIZATION BY Candida SPECIES IN THE ORAL CAVITY OF HIV-INFECTED INDIVIDUALS |
title_full_unstemmed |
RELATED FACTORS FOR COLONIZATION BY Candida SPECIES IN THE ORAL CAVITY OF HIV-INFECTED INDIVIDUALS |
title_sort |
related factors for colonization by candida species in the oral cavity of hiv-infected individuals |
publisher |
Universidade de São Paulo |
series |
Revista do Instituto de Medicina Tropical de São Paulo |
issn |
1678-9946 |
publishDate |
2015-10-01 |
description |
The colonization of the oral cavity is a prerequisite to the development of oropharyngeal candidiasis. Aims: The aims of this study were: to evaluate colonization and quantify Candida spp. in the oral cavity; to determine the predisposing factors for colonization; and to correlate the levels of CD4+ cells and viral load with the yeast count of colony forming units per milliliter (CFU/mL) in HIV-positive individuals treated at a University Hospital. Saliva samples were collected from 147 HIV patients and were plated on Sabouraud Dextrose Agar (SDA) and chromogenic agar, and incubated at 30 ºC for 72 h. Colonies with similar morphology in both media were counted and the result expressed in CFU/mL. Results: Of the 147 HIV patients, 89 had positive cultures for Candida spp., with a total of 111 isolates, of which C. albicans was the most frequent species (67.6%), and the mean of colonies counted was 8.8 × 10³ CFU/mL. The main predisposing factors for oral colonization by Candida spp. were the use of antibiotics and oral prostheses. The use of reverse transcriptase inhibitors appears to have a greater protective effect for colonization. A low CD4+ T lymphocyte count is associated with a higher density of yeast in the saliva of HIV patients. |
topic |
Candida, HIV Candidiasis Oral Colonization |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652015000500413&lng=en&tlng=en |
work_keys_str_mv |
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