Pyrrolizidine Alkaloids: Chemistry, Pharmacology, Toxicology and Food Safety

Pyrrolizidine Alkaloids: Chemistry, Pharmacology, Toxicology and Food Safety

Pyrrolizidine alkaloids (PA) are widely distributed in plants throughout the world, frequently in species relevant for human consumption. Apart from the toxicity that these molecules can cause in humans and livestock, PA are also known for their wide range of pharmacological properties, which can be...

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Main Authors: Rute Moreira, David M. Pereira, Patrícia Valentão, Paula B. Andrade
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:International Journal of Molecular Sciences
Subjects:
pyrrolizidine alkaloids
chemistry
toxicity
pharmacological properties
food safety
Online Access:http://www.mdpi.com/1422-0067/19/6/1668
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spelling doaj-e005b2044f7542cb9af3ab31990ca0312020-11-25T00:50:02ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-06-01196166810.3390/ijms19061668ijms19061668Pyrrolizidine Alkaloids: Chemistry, Pharmacology, Toxicology and Food SafetyRute Moreira0David M. Pereira1Patrícia Valentão2Paula B. Andrade3REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, R. Jorge Viterbo Ferreira, nº 228, 4050-313 Porto, PortugalREQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, R. Jorge Viterbo Ferreira, nº 228, 4050-313 Porto, PortugalREQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, R. Jorge Viterbo Ferreira, nº 228, 4050-313 Porto, PortugalREQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, R. Jorge Viterbo Ferreira, nº 228, 4050-313 Porto, PortugalPyrrolizidine alkaloids (PA) are widely distributed in plants throughout the world, frequently in species relevant for human consumption. Apart from the toxicity that these molecules can cause in humans and livestock, PA are also known for their wide range of pharmacological properties, which can be exploited in drug discovery programs. In this work we review the current body of knowledge regarding the chemistry, toxicology, pharmacology and food safety of PA.http://www.mdpi.com/1422-0067/19/6/1668pyrrolizidine alkaloidschemistrytoxicitypharmacological propertiesfood safety
collection DOAJ
language English
format Article
sources DOAJ
author Rute Moreira
David M. Pereira
Patrícia Valentão
Paula B. Andrade
spellingShingle Rute Moreira
David M. Pereira
Patrícia Valentão
Paula B. Andrade
Pyrrolizidine Alkaloids: Chemistry, Pharmacology, Toxicology and Food Safety
International Journal of Molecular Sciences
pyrrolizidine alkaloids
chemistry
toxicity
pharmacological properties
food safety
author_facet Rute Moreira
David M. Pereira
Patrícia Valentão
Paula B. Andrade
author_sort Rute Moreira
title Pyrrolizidine Alkaloids: Chemistry, Pharmacology, Toxicology and Food Safety
title_short Pyrrolizidine Alkaloids: Chemistry, Pharmacology, Toxicology and Food Safety
title_full Pyrrolizidine Alkaloids: Chemistry, Pharmacology, Toxicology and Food Safety
title_fullStr Pyrrolizidine Alkaloids: Chemistry, Pharmacology, Toxicology and Food Safety
title_full_unstemmed Pyrrolizidine Alkaloids: Chemistry, Pharmacology, Toxicology and Food Safety
title_sort pyrrolizidine alkaloids: chemistry, pharmacology, toxicology and food safety
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1422-0067
publishDate 2018-06-01
description Pyrrolizidine alkaloids (PA) are widely distributed in plants throughout the world, frequently in species relevant for human consumption. Apart from the toxicity that these molecules can cause in humans and livestock, PA are also known for their wide range of pharmacological properties, which can be exploited in drug discovery programs. In this work we review the current body of knowledge regarding the chemistry, toxicology, pharmacology and food safety of PA.
topic pyrrolizidine alkaloids
chemistry
toxicity
pharmacological properties
food safety
url http://www.mdpi.com/1422-0067/19/6/1668
work_keys_str_mv AT rutemoreira pyrrolizidinealkaloidschemistrypharmacologytoxicologyandfoodsafety
AT davidmpereira pyrrolizidinealkaloidschemistrypharmacologytoxicologyandfoodsafety
AT patriciavalentao pyrrolizidinealkaloidschemistrypharmacologytoxicologyandfoodsafety
AT paulabandrade pyrrolizidinealkaloidschemistrypharmacologytoxicologyandfoodsafety
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