Selective internal radiation therapy of hepatic tumors: Morphologic and functional imaging for voxel-based computer-aided dosimetry
Introduction: Selective Internal Radiation Therapy (SIRT) is used for the treatment of hepatic tumors. The aim of this retrospective study was to compare two dosimetric approaches based on 99mTc-MAA SPECT/CT and 90Y PET/CT, using Simplicit90Y™ versus the supplier suggested method of activity calcula...
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Format: | Article |
Language: | English |
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Elsevier
2020-12-01
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Series: | Biomedicine & Pharmacotherapy |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S075333222031057X |
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doaj-e00a436ac35043c89ee426d4a9c0d01a |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Andrea Skanjeti Nicolas Magand Didier Defez Jeremie Tordo Agnes Rode Anne Frederique Manichon François Hallouard Caroline Clave-Darcissac Anthony Dhomps Danyelle M. Townsend Domenico Rubello Francesco Giammarile |
spellingShingle |
Andrea Skanjeti Nicolas Magand Didier Defez Jeremie Tordo Agnes Rode Anne Frederique Manichon François Hallouard Caroline Clave-Darcissac Anthony Dhomps Danyelle M. Townsend Domenico Rubello Francesco Giammarile Selective internal radiation therapy of hepatic tumors: Morphologic and functional imaging for voxel-based computer-aided dosimetry Biomedicine & Pharmacotherapy SIRT Hepatic tumors Voxel-based dosimetry Survival |
author_facet |
Andrea Skanjeti Nicolas Magand Didier Defez Jeremie Tordo Agnes Rode Anne Frederique Manichon François Hallouard Caroline Clave-Darcissac Anthony Dhomps Danyelle M. Townsend Domenico Rubello Francesco Giammarile |
author_sort |
Andrea Skanjeti |
title |
Selective internal radiation therapy of hepatic tumors: Morphologic and functional imaging for voxel-based computer-aided dosimetry |
title_short |
Selective internal radiation therapy of hepatic tumors: Morphologic and functional imaging for voxel-based computer-aided dosimetry |
title_full |
Selective internal radiation therapy of hepatic tumors: Morphologic and functional imaging for voxel-based computer-aided dosimetry |
title_fullStr |
Selective internal radiation therapy of hepatic tumors: Morphologic and functional imaging for voxel-based computer-aided dosimetry |
title_full_unstemmed |
Selective internal radiation therapy of hepatic tumors: Morphologic and functional imaging for voxel-based computer-aided dosimetry |
title_sort |
selective internal radiation therapy of hepatic tumors: morphologic and functional imaging for voxel-based computer-aided dosimetry |
publisher |
Elsevier |
series |
Biomedicine & Pharmacotherapy |
issn |
0753-3322 |
publishDate |
2020-12-01 |
description |
Introduction: Selective Internal Radiation Therapy (SIRT) is used for the treatment of hepatic tumors. The aim of this retrospective study was to compare two dosimetric approaches based on 99mTc-MAA SPECT/CT and 90Y PET/CT, using Simplicit90Y™ versus the supplier suggested method of activity calculation. Material and methods: A total of 19 patients underwent 21 SIRT after baseline angiography and 99mTc-MAA SPECT/CT, followed by 90Y PET/CT. Overlap between 99mTc-MAA and 90Y-microspheres was quantified with different thresholds isocontours. The perfused volume and tumor absorbed dose were estimated using Simplicit90Y™ based on SPECT/CT and PET/CT, then compared with the supplier suggested method. These data were related to overall survival to evaluate their prognostic impact. Results: The overlap between PET/CT and SPECT/CT was dependent on thresholds, decreasing with an increasing threshold. The overlap between the 99mTc-MAA and 90Y-microspheres biodistributions versus the tumor distribution on morphological imaging was suboptimal, in particular for small tumor volume. The tumor absorbed dose estimated after 90Y PET/CT was not different from tumor absorbed dose estimated after SPECT/CT. The Perfused lobe absorbed dose was significantly lower while the volume of the perfused lobe was significantly higher when estimated by Simplicit90Y™ compared to the supplier suggested conventional approach. A statistical parameter based on overlap between tumor and 90Y-microspheres distribution as well as tumoral dosimetry was significantly related to the overall survival. Conclusion: Post-treatment imaging remains paramount to estimate the irradiation dosimetry, due to an imperfect overlap. The perfused volume could be estimated from functional imaging, given its impact on dosimetry. Finally, survival seems related to tumoral overlap and dosimetry. |
topic |
SIRT Hepatic tumors Voxel-based dosimetry Survival |
url |
http://www.sciencedirect.com/science/article/pii/S075333222031057X |
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doaj-e00a436ac35043c89ee426d4a9c0d01a2021-05-21T04:18:32ZengElsevierBiomedicine & Pharmacotherapy0753-33222020-12-01132110865Selective internal radiation therapy of hepatic tumors: Morphologic and functional imaging for voxel-based computer-aided dosimetryAndrea Skanjeti0Nicolas Magand1Didier Defez2Jeremie Tordo3Agnes Rode4Anne Frederique Manichon5François Hallouard6Caroline Clave-Darcissac7Anthony Dhomps8Danyelle M. Townsend9Domenico Rubello10Francesco Giammarile11Nuclear Medicine Department, Hospices Civils de Lyon, 165 Chemin du Grand Revoyet, 69310 Pierre-Bénite, France; EA 3738, Université Claude Bernard Lyon 1, 165 Chemin du Grand Revoyet, 69310 Pierre-Bénite, France; Corresponding author at: Nuclear Medicine Department, Hospices Civils de Lyon, EA 3738, Université Claude Bernard Lyon 1, 165 Chemin du Grand Revoyet, 69310 Pierre-Bénite, France.Radiology Department, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, 103 Grande Rue de la Croix-Rousse, 69004 Lyon, FranceMedical Physics Department, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, 165 Chemin du Grand Revoyet, 69310 Pierre-Bénite, FranceNuclear Medicine Department, Hospices Civils de Lyon, 165 Chemin du Grand Revoyet, 69310 Pierre-Bénite, FranceRadiology Department, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, 103 Grande Rue de la Croix-Rousse, 69004 Lyon, FranceRadiology Department, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, 103 Grande Rue de la Croix-Rousse, 69004 Lyon, FranceRadiopharmacy Unit, Pharmacy Department, Groupement Hospitalier Sud, Hospices Civils de Lyon, 165 Chemin du Grand Revoyet, 69310 Pierre-Bénite, FranceRadiopharmacy Unit, Pharmacy Department, Groupement Hospitalier Sud, Hospices Civils de Lyon, 165 Chemin du Grand Revoyet, 69310 Pierre-Bénite, FranceNuclear Medicine Department, Hospices Civils de Lyon, 165 Chemin du Grand Revoyet, 69310 Pierre-Bénite, FranceDrug Discovery and Pharmaceutical Sciences, Medical University of South Carolina, 70 President St, Charleston, SC 29425,USANuclear Medicine Unit, Santa Maria della Misericordia Hospital, Viale Tre Martiri, 140, 45100 Rovigo, ItalyDivision of Human Health, International Atomic Energy Agency, Wagramer Str. 5, 1220 Vienna, AustriaIntroduction: Selective Internal Radiation Therapy (SIRT) is used for the treatment of hepatic tumors. The aim of this retrospective study was to compare two dosimetric approaches based on 99mTc-MAA SPECT/CT and 90Y PET/CT, using Simplicit90Y™ versus the supplier suggested method of activity calculation. Material and methods: A total of 19 patients underwent 21 SIRT after baseline angiography and 99mTc-MAA SPECT/CT, followed by 90Y PET/CT. Overlap between 99mTc-MAA and 90Y-microspheres was quantified with different thresholds isocontours. The perfused volume and tumor absorbed dose were estimated using Simplicit90Y™ based on SPECT/CT and PET/CT, then compared with the supplier suggested method. These data were related to overall survival to evaluate their prognostic impact. Results: The overlap between PET/CT and SPECT/CT was dependent on thresholds, decreasing with an increasing threshold. The overlap between the 99mTc-MAA and 90Y-microspheres biodistributions versus the tumor distribution on morphological imaging was suboptimal, in particular for small tumor volume. The tumor absorbed dose estimated after 90Y PET/CT was not different from tumor absorbed dose estimated after SPECT/CT. The Perfused lobe absorbed dose was significantly lower while the volume of the perfused lobe was significantly higher when estimated by Simplicit90Y™ compared to the supplier suggested conventional approach. A statistical parameter based on overlap between tumor and 90Y-microspheres distribution as well as tumoral dosimetry was significantly related to the overall survival. Conclusion: Post-treatment imaging remains paramount to estimate the irradiation dosimetry, due to an imperfect overlap. The perfused volume could be estimated from functional imaging, given its impact on dosimetry. Finally, survival seems related to tumoral overlap and dosimetry.http://www.sciencedirect.com/science/article/pii/S075333222031057XSIRTHepatic tumorsVoxel-based dosimetrySurvival |