Effects of surfactants on preterm infant lungs
Lack of surfactant is the commonest cause of death in preterm infants. Their lungs may contain as little as 10 mg/ kg of surfactant at birth, a tenth of the amount normally found at term. Surfactants (animal origin or synthetic) can reduce mortality by 40% in infants with less than 30 weeks of gesta...
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doaj-e00dd816eaea47dc94a1458683cdbf742020-11-25T03:05:38ZengMavera, Edições Científicas e Técnicas LtdaMedical Express2358-04292210.5935/MedicalExpress.2015.02.06S2358-04292015000200006Effects of surfactants on preterm infant lungsGian Maria PacificiLack of surfactant is the commonest cause of death in preterm infants. Their lungs may contain as little as 10 mg/ kg of surfactant at birth, a tenth of the amount normally found at term. Surfactants (animal origin or synthetic) can reduce mortality by 40% in infants with less than 30 weeks of gestation. Poractant is the surfactant derived from minced porcine lungs, Beractant from minced bovine lungs. Bronchoalveolar lavage with diluted poractant is effective in mechanically ventilated term infants with severe acute respiratory distress syndrome due to meconium aspiration syndrome. Nebulized surfactant and mask airway surfactant do not require intubation. Alternatively, surfactant may be administered via a thin catheter during spontaneous breathing. In conclusion, surfactants reduce the mortality in preterm infants.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2358-04292015000200006&lng=en&tlng=enberactantporactantecalfactantneonatesurfactant |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gian Maria Pacifici |
spellingShingle |
Gian Maria Pacifici Effects of surfactants on preterm infant lungs Medical Express beractant poractante calfactant neonate surfactant |
author_facet |
Gian Maria Pacifici |
author_sort |
Gian Maria Pacifici |
title |
Effects of surfactants on preterm infant lungs |
title_short |
Effects of surfactants on preterm infant lungs |
title_full |
Effects of surfactants on preterm infant lungs |
title_fullStr |
Effects of surfactants on preterm infant lungs |
title_full_unstemmed |
Effects of surfactants on preterm infant lungs |
title_sort |
effects of surfactants on preterm infant lungs |
publisher |
Mavera, Edições Científicas e Técnicas Ltda |
series |
Medical Express |
issn |
2358-0429 |
description |
Lack of surfactant is the commonest cause of death in preterm infants. Their lungs may contain as little as 10 mg/ kg of surfactant at birth, a tenth of the amount normally found at term. Surfactants (animal origin or synthetic) can reduce mortality by 40% in infants with less than 30 weeks of gestation. Poractant is the surfactant derived from minced porcine lungs, Beractant from minced bovine lungs. Bronchoalveolar lavage with diluted poractant is effective in mechanically ventilated term infants with severe acute respiratory distress syndrome due to meconium aspiration syndrome. Nebulized surfactant and mask airway surfactant do not require intubation. Alternatively, surfactant may be administered via a thin catheter during spontaneous breathing. In conclusion, surfactants reduce the mortality in preterm infants. |
topic |
beractant poractante calfactant neonate surfactant |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2358-04292015000200006&lng=en&tlng=en |
work_keys_str_mv |
AT gianmariapacifici effectsofsurfactantsonpreterminfantlungs |
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