Metastasis of the epididymis and spermatic cord from pancreatic adenocarcinoma: A rare entity. Description of a case and revision of literature
Introduction: Metastatic epididymal and spermatic cord adenocarcinoma from epithelial tumors are a rare condition. The most frequent primary cancers are prostate, lung, kidney, gastrointestinal tumors and breast. In literature, there are very low number of cases reporting metastasis from pancreatic...
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doaj-e0185cd936d54acbb605c7f86c6b93e82020-11-25T03:17:54ZengPAGEPress PublicationsArchivio Italiano di Urologia e Andrologia1124-35622282-41972018-03-01901727310.4081/aiua.2018.1.725651Metastasis of the epididymis and spermatic cord from pancreatic adenocarcinoma: A rare entity. Description of a case and revision of literatureCarmelo Agostino Di Franco0Bruno Rovereto1Daniele Porru2Valeria Zoccarato3Cesare Regina4Tiziano Cebrelli5Nicolò Fiorello6Alessandra Viglio7Lavinia Galvagno8Carlo Marchetti9Andrea Ringressi10Davide Barletta11Giovanni Giliberto12Department of Urology, University Hospital IRCCS Policlinico S.Matteo of PaviaDepartment of Urology, University Hospital IRCCS Policlinico S.Matteo of PaviaDepartment of Urology, University Hospital IRCCS Policlinico S.Matteo of PaviaDepartment of Urology, University Hospital IRCCS Policlinico S.Matteo of PaviaDepartment of Urology, University Hospital IRCCS Policlinico S.Matteo of PaviaDepartment of Urology, University Hospital IRCCS Policlinico S.Matteo of PaviaDepartment of Urology, University Hospital IRCCS Policlinico S.Matteo of PaviaDepartment of Pathology, University Hospital IRCCS Policlinico S.Matteo of PaviaLanguage and Translation Services, EnnaDepartment of Urology, University Hospital IRCCS Policlinico S.Matteo of PaviaDepartment of Urology, University Hospital IRCCS Policlinico S.Matteo of PaviaDepartment of Urology, University Hospital IRCCS Policlinico S.Matteo of PaviaDepartment of Urology, University Hospital IRCCS Policlinico S.Matteo of PaviaIntroduction: Metastatic epididymal and spermatic cord adenocarcinoma from epithelial tumors are a rare condition. The most frequent primary cancers are prostate, lung, kidney, gastrointestinal tumors and breast. In literature, there are very low number of cases reporting metastasis from pancreatic cancer to epididymis and spermatic cord. Case description: We report a case of 70-years old man with history of left orchiectomy for undescended testicle, who presented to our department with a palpable nodule in the right scrotum. Scrotal ultrasound revealed an inhomogeneous hypoechoic nodule of epididymis and/or spermatic cord. Neoplastic markers showed high levels of CEA (carcinoembryonic antigen) and bHCG (beta Human Chorionic Gonadotropin). The patient underwent right surgical scrotal exploration with orchifunicolectomy. Pathologic examination revealed pathologic tissue showing rare glandular structures. Immunohistochemistry profile was compatible with malign epithelial neoplasm with glandular differentiation. Total body CT-scan revealed pathologic tissue in pancreas between head and body and a suspect pathologic lesion in liver and 18-FDG PET-scan confirmed the pancreatic neoplastic mass and a suspect secondary hepatic lesion. Biopsy of pancreatic pathologic area was positive for ductal pancreatic adenocarcinoma. The patient was sent to oncologic evaluation and started chemotherapy. Conclusions: Malignancies of epididymis and spermatic cord are rare entities and, in literature, very low number of cases of metastasis from pancreatic carcinoma to epididymis and spermatic cord are described. Early differential diagnosis is fundamental mostly in those patients with age range unusual for testis cancers.http://www.pagepressjournals.org/index.php/aiua/article/view/7279UrologyAndrologyspermatic cordpancreascancerpancreatic metastasisItalyOncologyEpididymismetastasisscrotal cancer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Carmelo Agostino Di Franco Bruno Rovereto Daniele Porru Valeria Zoccarato Cesare Regina Tiziano Cebrelli Nicolò Fiorello Alessandra Viglio Lavinia Galvagno Carlo Marchetti Andrea Ringressi Davide Barletta Giovanni Giliberto |
spellingShingle |
Carmelo Agostino Di Franco Bruno Rovereto Daniele Porru Valeria Zoccarato Cesare Regina Tiziano Cebrelli Nicolò Fiorello Alessandra Viglio Lavinia Galvagno Carlo Marchetti Andrea Ringressi Davide Barletta Giovanni Giliberto Metastasis of the epididymis and spermatic cord from pancreatic adenocarcinoma: A rare entity. Description of a case and revision of literature Archivio Italiano di Urologia e Andrologia Urology Andrology spermatic cord pancreas cancer pancreatic metastasis Italy Oncology Epididymis metastasis scrotal cancer |
author_facet |
Carmelo Agostino Di Franco Bruno Rovereto Daniele Porru Valeria Zoccarato Cesare Regina Tiziano Cebrelli Nicolò Fiorello Alessandra Viglio Lavinia Galvagno Carlo Marchetti Andrea Ringressi Davide Barletta Giovanni Giliberto |
author_sort |
Carmelo Agostino Di Franco |
title |
Metastasis of the epididymis and spermatic cord from pancreatic adenocarcinoma: A rare entity. Description of a case and revision of literature |
title_short |
Metastasis of the epididymis and spermatic cord from pancreatic adenocarcinoma: A rare entity. Description of a case and revision of literature |
title_full |
Metastasis of the epididymis and spermatic cord from pancreatic adenocarcinoma: A rare entity. Description of a case and revision of literature |
title_fullStr |
Metastasis of the epididymis and spermatic cord from pancreatic adenocarcinoma: A rare entity. Description of a case and revision of literature |
title_full_unstemmed |
Metastasis of the epididymis and spermatic cord from pancreatic adenocarcinoma: A rare entity. Description of a case and revision of literature |
title_sort |
metastasis of the epididymis and spermatic cord from pancreatic adenocarcinoma: a rare entity. description of a case and revision of literature |
publisher |
PAGEPress Publications |
series |
Archivio Italiano di Urologia e Andrologia |
issn |
1124-3562 2282-4197 |
publishDate |
2018-03-01 |
description |
Introduction: Metastatic epididymal and spermatic cord adenocarcinoma from epithelial tumors are a rare condition. The most frequent primary cancers are prostate, lung, kidney, gastrointestinal tumors and breast. In literature, there are very low number of cases reporting metastasis from pancreatic cancer to epididymis and spermatic cord.
Case description: We report a case of 70-years old man with history of left orchiectomy for undescended testicle, who presented to our department with a palpable nodule in the right scrotum. Scrotal ultrasound revealed an inhomogeneous hypoechoic nodule of epididymis and/or spermatic cord. Neoplastic markers showed high levels of CEA (carcinoembryonic antigen) and bHCG (beta Human Chorionic Gonadotropin). The patient underwent right surgical scrotal exploration with orchifunicolectomy. Pathologic examination revealed pathologic tissue showing rare glandular structures. Immunohistochemistry profile was compatible with malign epithelial neoplasm with glandular differentiation. Total body CT-scan revealed pathologic tissue in pancreas between head and body and a suspect pathologic lesion in liver and 18-FDG PET-scan confirmed the pancreatic neoplastic mass and a suspect secondary hepatic lesion. Biopsy of pancreatic pathologic area was positive for ductal pancreatic adenocarcinoma. The patient was sent to oncologic evaluation and started chemotherapy.
Conclusions: Malignancies of epididymis and spermatic cord are rare entities and, in literature, very low number of cases of metastasis from pancreatic carcinoma to epididymis and spermatic cord are described. Early differential diagnosis is fundamental mostly in those patients with age range unusual for testis cancers. |
topic |
Urology Andrology spermatic cord pancreas cancer pancreatic metastasis Italy Oncology Epididymis metastasis scrotal cancer |
url |
http://www.pagepressjournals.org/index.php/aiua/article/view/7279 |
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