Heterogeneity of Glucose Transport in Lung Cancer

Increased glucose uptake is a known hallmark of cancer. Cancer cells need glucose for energy production via glycolysis and the tricarboxylic acid cycle, and also to fuel the pentose phosphate pathway, the serine biosynthetic pathway, lipogenesis, and the hexosamine pathway. For this reason, glucose...

Full description

Bibliographic Details
Main Authors:	Cesar A. Martinez, Claudio Scafoglio
Format:	Article
Language:	English
Published:	MDPI AG 2020-06-01
Series:	Biomolecules
Subjects:	glucose metabolism glucose transport cancer lung cancer tumor heterogeneity
Online Access:	https://www.mdpi.com/2218-273X/10/6/868

id	doaj-e02059c7aff54fe7bc88a07992c67051
record_format	Article
spelling	doaj-e02059c7aff54fe7bc88a07992c670512020-11-25T03:25:12ZengMDPI AGBiomolecules2218-273X2020-06-011086886810.3390/biom10060868Heterogeneity of Glucose Transport in Lung CancerCesar A. Martinez0Claudio Scafoglio1Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USADivision of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USAIncreased glucose uptake is a known hallmark of cancer. Cancer cells need glucose for energy production via glycolysis and the tricarboxylic acid cycle, and also to fuel the pentose phosphate pathway, the serine biosynthetic pathway, lipogenesis, and the hexosamine pathway. For this reason, glucose transport inhibition is an emerging new treatment for different malignancies, including lung cancer. However, studies both in animal models and in humans have shown high levels of heterogeneity in the utilization of glucose and other metabolites in cancer, unveiling a complexity that is difficult to target therapeutically. Here, we present an overview of different levels of heterogeneity in glucose uptake and utilization in lung cancer, with diagnostic and therapeutic implications.https://www.mdpi.com/2218-273X/10/6/868glucose metabolismglucose transportcancerlung cancertumor heterogeneity
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Cesar A. Martinez Claudio Scafoglio
spellingShingle	Cesar A. Martinez Claudio Scafoglio Heterogeneity of Glucose Transport in Lung Cancer Biomolecules glucose metabolism glucose transport cancer lung cancer tumor heterogeneity
author_facet	Cesar A. Martinez Claudio Scafoglio
author_sort	Cesar A. Martinez
title	Heterogeneity of Glucose Transport in Lung Cancer
title_short	Heterogeneity of Glucose Transport in Lung Cancer
title_full	Heterogeneity of Glucose Transport in Lung Cancer
title_fullStr	Heterogeneity of Glucose Transport in Lung Cancer
title_full_unstemmed	Heterogeneity of Glucose Transport in Lung Cancer
title_sort	heterogeneity of glucose transport in lung cancer
publisher	MDPI AG
series	Biomolecules
issn	2218-273X
publishDate	2020-06-01
description	Increased glucose uptake is a known hallmark of cancer. Cancer cells need glucose for energy production via glycolysis and the tricarboxylic acid cycle, and also to fuel the pentose phosphate pathway, the serine biosynthetic pathway, lipogenesis, and the hexosamine pathway. For this reason, glucose transport inhibition is an emerging new treatment for different malignancies, including lung cancer. However, studies both in animal models and in humans have shown high levels of heterogeneity in the utilization of glucose and other metabolites in cancer, unveiling a complexity that is difficult to target therapeutically. Here, we present an overview of different levels of heterogeneity in glucose uptake and utilization in lung cancer, with diagnostic and therapeutic implications.
topic	glucose metabolism glucose transport cancer lung cancer tumor heterogeneity
url	https://www.mdpi.com/2218-273X/10/6/868
work_keys_str_mv	AT cesaramartinez heterogeneityofglucosetransportinlungcancer AT claudioscafoglio heterogeneityofglucosetransportinlungcancer
_version_	1724598258825691136

Heterogeneity of Glucose Transport in Lung Cancer

Similar Items