Prognostic factors of brain metastases from colorectal cancer
Abstract Background For brain metastases from non-specific primary tumors, the most frequently used and validated clinical prognostic assessment tool is Karnofsky performance status (KPS). Given the lack of prognostic factors of brain metastases from colorectal cancer (CRC) other than KPS, this stud...
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doaj-e04054e5ac8f437da5697a1e5eeba9d82020-11-25T02:57:48ZengBMCBMC Cancer1471-24072019-07-011911710.1186/s12885-019-5973-xPrognostic factors of brain metastases from colorectal cancerJun Imaizumi0Dai Shida1Yoshitaka Narita2Yasuji Miyakita3Taro Tanabe4Atsuo Takashima5Narikazu Boku6Hiroshi Igaki7Jun Itami8Yukihide Kanemitsu9Department of Colorectal Surgery, National Cancer Center HospitalDepartment of Colorectal Surgery, National Cancer Center HospitalDepartment of Neurosurgery and Neuro-Oncology, National Cancer Center HospitalDepartment of Neurosurgery and Neuro-Oncology, National Cancer Center HospitalDepartment of Colorectal Surgery, National Cancer Center HospitalGastrointestinal Medical Oncology Division, National Cancer Center HospitalGastrointestinal Medical Oncology Division, National Cancer Center HospitalDepartment of Radiation Oncology, National Cancer Center HospitalDepartment of Radiation Oncology, National Cancer Center HospitalDepartment of Colorectal Surgery, National Cancer Center HospitalAbstract Background For brain metastases from non-specific primary tumors, the most frequently used and validated clinical prognostic assessment tool is Karnofsky performance status (KPS). Given the lack of prognostic factors of brain metastases from colorectal cancer (CRC) other than KPS, this study aimed to identify new prognostic factors. Methods This retrospective cohort study was conducted at a tertiary care cancer center. Subjects were patients with brain metastases from CRC among all patients who received initial treatment for CRC at the National Cancer Center Hospital from 1997 to 2015 (n = 7147). Prognostic clinicopathological variables for overall survival (OS) were investigated. Results There were 68 consecutive patients with brain metastases from CRC, corresponding to 1.0% of all patients with CRC during the study period. Median survival time was 6.8 months. One-year and 3-year OS rates were 28.0 and 10.1%, respectively. Among the six covariates tested (age, KPS, presence of extracranial metastases, control of primary lesion, number of brain metastases, and history of chemotherapy), multivariate analysis revealed KPS (score ≥ 70), number of brain metastases (1–3), and no history of chemotherapy to be independent factors associated with better prognosis. Conclusions In addition to KPS, the number of brain lesions and history of chemotherapy were independent prognostic factors for OS in patients with brain metastases from CRC. An awareness of these factors may help gastrointestinal surgeons make appropriate choices in the treatment of these patients.http://link.springer.com/article/10.1186/s12885-019-5973-xBrain metastasesColorectal cancerKarnofsky performance status |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jun Imaizumi Dai Shida Yoshitaka Narita Yasuji Miyakita Taro Tanabe Atsuo Takashima Narikazu Boku Hiroshi Igaki Jun Itami Yukihide Kanemitsu |
spellingShingle |
Jun Imaizumi Dai Shida Yoshitaka Narita Yasuji Miyakita Taro Tanabe Atsuo Takashima Narikazu Boku Hiroshi Igaki Jun Itami Yukihide Kanemitsu Prognostic factors of brain metastases from colorectal cancer BMC Cancer Brain metastases Colorectal cancer Karnofsky performance status |
author_facet |
Jun Imaizumi Dai Shida Yoshitaka Narita Yasuji Miyakita Taro Tanabe Atsuo Takashima Narikazu Boku Hiroshi Igaki Jun Itami Yukihide Kanemitsu |
author_sort |
Jun Imaizumi |
title |
Prognostic factors of brain metastases from colorectal cancer |
title_short |
Prognostic factors of brain metastases from colorectal cancer |
title_full |
Prognostic factors of brain metastases from colorectal cancer |
title_fullStr |
Prognostic factors of brain metastases from colorectal cancer |
title_full_unstemmed |
Prognostic factors of brain metastases from colorectal cancer |
title_sort |
prognostic factors of brain metastases from colorectal cancer |
publisher |
BMC |
series |
BMC Cancer |
issn |
1471-2407 |
publishDate |
2019-07-01 |
description |
Abstract Background For brain metastases from non-specific primary tumors, the most frequently used and validated clinical prognostic assessment tool is Karnofsky performance status (KPS). Given the lack of prognostic factors of brain metastases from colorectal cancer (CRC) other than KPS, this study aimed to identify new prognostic factors. Methods This retrospective cohort study was conducted at a tertiary care cancer center. Subjects were patients with brain metastases from CRC among all patients who received initial treatment for CRC at the National Cancer Center Hospital from 1997 to 2015 (n = 7147). Prognostic clinicopathological variables for overall survival (OS) were investigated. Results There were 68 consecutive patients with brain metastases from CRC, corresponding to 1.0% of all patients with CRC during the study period. Median survival time was 6.8 months. One-year and 3-year OS rates were 28.0 and 10.1%, respectively. Among the six covariates tested (age, KPS, presence of extracranial metastases, control of primary lesion, number of brain metastases, and history of chemotherapy), multivariate analysis revealed KPS (score ≥ 70), number of brain metastases (1–3), and no history of chemotherapy to be independent factors associated with better prognosis. Conclusions In addition to KPS, the number of brain lesions and history of chemotherapy were independent prognostic factors for OS in patients with brain metastases from CRC. An awareness of these factors may help gastrointestinal surgeons make appropriate choices in the treatment of these patients. |
topic |
Brain metastases Colorectal cancer Karnofsky performance status |
url |
http://link.springer.com/article/10.1186/s12885-019-5973-x |
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