Milled flaxseed-added diets ameliorated hepatic inflammation by reducing gene expression of TLR4/NF-κB pathway and altered gut microbiota in STZ-induced type 1 diabetic mice

Milled flaxseed-added diets ameliorated hepatic inflammation by reducing gene expression of TLR4/NF-κB pathway and altered gut microbiota in STZ-induced type 1 diabetic mice

Flaxseed has displayed the potential beneficial as functional foods. However, most studies focused on effects of flaxseed extracts or ingredients in flaxseed. Besides, few studies showed that flaxseed extracts contributed to anti-type 1 diabetes (T1D), yet the underlying mechanism is still unknown....

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Main Authors: Hui Xia, Xiangling Shi, Beijia Zhou, Jing Sui, Chao Yang, Hechun Liu, Ligang Yang, Shaokang Wang, Guiju Sun
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2022-01-01
Series:Food Science and Human Wellness
Subjects:
Milled flaxseed
Type 1 diabetes
Gut microbiota
TLR4/NF-κB pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S2213453021000707
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spelling doaj-e043d5d5d7624957a030e223ee581ce32021-09-13T04:14:02ZengKeAi Communications Co., Ltd.Food Science and Human Wellness2213-45302022-01-011113240Milled flaxseed-added diets ameliorated hepatic inflammation by reducing gene expression of TLR4/NF-κB pathway and altered gut microbiota in STZ-induced type 1 diabetic miceHui Xia0Xiangling Shi1Beijia Zhou2Jing Sui3Chao Yang4Hechun Liu5Ligang Yang6Shaokang Wang7Guiju Sun8Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, ChinaResearch Institute for Environment and Health, School of Law and Public Affairs, Nanjing University of Information Science and Technology, Nanjing, Jiangsu, 210044, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China; Corresponding author at: Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food hygiene, School of Public Health, Southeast University, Nanjing 210009, China.Flaxseed has displayed the potential beneficial as functional foods. However, most studies focused on effects of flaxseed extracts or ingredients in flaxseed. Besides, few studies showed that flaxseed extracts contributed to anti-type 1 diabetes (T1D), yet the underlying mechanism is still unknown. In the present study, 16.7% of milled flaxseed (MF)-added diet was given to diabetic mice induced by streptozocin for 6 weeks. The results showed that MF feeding 1) slightly decreased blood glucose levels and improved the ability of glucose tolerance by oral glucose tolerance test, 2) decreased liver tumor necrosis factor-α levels and increased liver glycogen levels with significance via down-regulating TLR4/NF-κB pathways, 3) and significantly altered some beneficial bacteria in gut microbiota. In conclusion, the present study showed that milled flaxseed showed the potential on anti-T1D through anti-inflammation via TLR4/NF-κB and altering the gut microbiota in STZ-induced diabetic mice.http://www.sciencedirect.com/science/article/pii/S2213453021000707Milled flaxseedType 1 diabetesGut microbiotaTLR4/NF-κB pathway
collection DOAJ
language English
format Article
sources DOAJ
author Hui Xia
Xiangling Shi
Beijia Zhou
Jing Sui
Chao Yang
Hechun Liu
Ligang Yang
Shaokang Wang
Guiju Sun
spellingShingle Hui Xia
Xiangling Shi
Beijia Zhou
Jing Sui
Chao Yang
Hechun Liu
Ligang Yang
Shaokang Wang
Guiju Sun
Milled flaxseed-added diets ameliorated hepatic inflammation by reducing gene expression of TLR4/NF-κB pathway and altered gut microbiota in STZ-induced type 1 diabetic mice
Food Science and Human Wellness
Milled flaxseed
Type 1 diabetes
Gut microbiota
TLR4/NF-κB pathway
author_facet Hui Xia
Xiangling Shi
Beijia Zhou
Jing Sui
Chao Yang
Hechun Liu
Ligang Yang
Shaokang Wang
Guiju Sun
author_sort Hui Xia
title Milled flaxseed-added diets ameliorated hepatic inflammation by reducing gene expression of TLR4/NF-κB pathway and altered gut microbiota in STZ-induced type 1 diabetic mice
title_short Milled flaxseed-added diets ameliorated hepatic inflammation by reducing gene expression of TLR4/NF-κB pathway and altered gut microbiota in STZ-induced type 1 diabetic mice
title_full Milled flaxseed-added diets ameliorated hepatic inflammation by reducing gene expression of TLR4/NF-κB pathway and altered gut microbiota in STZ-induced type 1 diabetic mice
title_fullStr Milled flaxseed-added diets ameliorated hepatic inflammation by reducing gene expression of TLR4/NF-κB pathway and altered gut microbiota in STZ-induced type 1 diabetic mice
title_full_unstemmed Milled flaxseed-added diets ameliorated hepatic inflammation by reducing gene expression of TLR4/NF-κB pathway and altered gut microbiota in STZ-induced type 1 diabetic mice
title_sort milled flaxseed-added diets ameliorated hepatic inflammation by reducing gene expression of tlr4/nf-κb pathway and altered gut microbiota in stz-induced type 1 diabetic mice
publisher KeAi Communications Co., Ltd.
series Food Science and Human Wellness
issn 2213-4530
publishDate 2022-01-01
description Flaxseed has displayed the potential beneficial as functional foods. However, most studies focused on effects of flaxseed extracts or ingredients in flaxseed. Besides, few studies showed that flaxseed extracts contributed to anti-type 1 diabetes (T1D), yet the underlying mechanism is still unknown. In the present study, 16.7% of milled flaxseed (MF)-added diet was given to diabetic mice induced by streptozocin for 6 weeks. The results showed that MF feeding 1) slightly decreased blood glucose levels and improved the ability of glucose tolerance by oral glucose tolerance test, 2) decreased liver tumor necrosis factor-α levels and increased liver glycogen levels with significance via down-regulating TLR4/NF-κB pathways, 3) and significantly altered some beneficial bacteria in gut microbiota. In conclusion, the present study showed that milled flaxseed showed the potential on anti-T1D through anti-inflammation via TLR4/NF-κB and altering the gut microbiota in STZ-induced diabetic mice.
topic Milled flaxseed
Type 1 diabetes
Gut microbiota
TLR4/NF-κB pathway
url http://www.sciencedirect.com/science/article/pii/S2213453021000707
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