Independent predictors of cytomegalovirus vertical transmission in children with perinatal HIV contact

• Main Authors: V. B. Denisenko, E. N. Simovanian, V. V. Pushkarnaya
• Format: Article
• Language: Russian
• Published: Journal Infectology 2014-09-01
• Series: Žurnal Infektologii
• Subjects: children; cytomegalovirus infection; perinatal hiv contact independent predictors
• Online Access: https://journal.niidi.ru/jofin/article/view/152

102 pair «HIV infected pregnant women with cytomegalovirus infection – HIV negative child» were examined. Cytomegalovirus vertical transmission were realized in 20% women. Congenital cytomegalovirus infection in 90% children were proceed in clinical demonstrative form with severe multiorgan pathology formation. Multifactorial logistic regression model use demonstrate, that independent predictors of cytomegalovirus vertical transmission were T helper count less than 0,5×109/l, stage of secondary diseases and threat of pregnancy interruption. Forecasting of risk cytomegalovirus vertical transmission sensitivity and specificity in the presence of at the same time all three predictors were 90%.