The efficacy of honey and a Thai Herbal Oil preparation in the treatment of pressure ulcers based on Thai traditional medicine wound diagnosis versus standard practice: An open-label randomized controlled trial
Background: Scientific support for Thai traditional medicine (TTM) practice is warranted for reintroduction into modern healthcare systems. A promising TTM practice for treatment of pressure ulcers was selected to conduct a clinical trial. This study aimed to evaluate the efficacy of the TTM practic...
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doaj-e04d94a80c1943c48dd4fba2cff619e52020-11-25T00:45:23ZengElsevierContemporary Clinical Trials Communications2451-86542020-03-0117The efficacy of honey and a Thai Herbal Oil preparation in the treatment of pressure ulcers based on Thai traditional medicine wound diagnosis versus standard practice: An open-label randomized controlled trialSomtanuek Chotchoungchatchai0Orapitchaya Krairit1Pramote Tragulpiankit2Sompop Prathanturarug3Department of Pharmaceutical Botany, Faculty of Pharmacy, Mahidol University, Bangkok, ThailandDepartment of Internal Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, ThailandDepartment of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, ThailandDepartment of Pharmaceutical Botany, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand; Corresponding author. Department of Pharmaceutical Botany, Faculty of Pharmacy, Mahidol University, 447 Sri-Ayuthaya Road, Bangkok, 10400, Thailand.Background: Scientific support for Thai traditional medicine (TTM) practice is warranted for reintroduction into modern healthcare systems. A promising TTM practice for treatment of pressure ulcers was selected to conduct a clinical trial. This study aimed to evaluate the efficacy of the TTM practice for the treatment of pressure ulcers using honey or a Thai Herbal Oil preparation (THO) based on the TTM wound diagnosis comparing with the standard practice. Methods: The study design was an open-label randomized controlled trial. Sixty-six participants, with pressure ulcers at least stage II-IV or unstageable, were allocated to two groups via minimization. A TTM practice group received honey or THO depending on the TTM diagnosis via the Thai Traditional Medicine Pressure Ulcer Assessment Tool (TTM-PUAT). A standard practice group received advanced dressings, including hydrogel, alginate, silver-impregnated, or hydrocolloid dressings. The primary outcome was the Pressure Ulcer Scale for Healing (PUSH). Results: Both TTM practice and standard practice showed a significant reduction in PUSH scores after treatments. However, there was no significant difference in PUSH score reduction between the groups. The mean PUSH score reduction over the 6-week period was 2.58 ± 3.38 (95% CI 1.34–3.82) in the TTM practice group and 3.24 ± 3.49 (95% CI 1.91–4.57) in the standard practice group (p = 0.284). The TTM practice and standard practice accelerated pressure ulcer healing without statistically significant difference between the practices, during 6 weeks in a home-based care setting. This finding supported the TTM practice as an alternative treatment for pressure ulcer. Keywords: Decubitus, Diagnosis, Honey, Clinacanthus nutans, Zingiber montanum, Traditional medicinehttp://www.sciencedirect.com/science/article/pii/S2451865420300223 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Somtanuek Chotchoungchatchai Orapitchaya Krairit Pramote Tragulpiankit Sompop Prathanturarug |
spellingShingle |
Somtanuek Chotchoungchatchai Orapitchaya Krairit Pramote Tragulpiankit Sompop Prathanturarug The efficacy of honey and a Thai Herbal Oil preparation in the treatment of pressure ulcers based on Thai traditional medicine wound diagnosis versus standard practice: An open-label randomized controlled trial Contemporary Clinical Trials Communications |
author_facet |
Somtanuek Chotchoungchatchai Orapitchaya Krairit Pramote Tragulpiankit Sompop Prathanturarug |
author_sort |
Somtanuek Chotchoungchatchai |
title |
The efficacy of honey and a Thai Herbal Oil preparation in the treatment of pressure ulcers based on Thai traditional medicine wound diagnosis versus standard practice: An open-label randomized controlled trial |
title_short |
The efficacy of honey and a Thai Herbal Oil preparation in the treatment of pressure ulcers based on Thai traditional medicine wound diagnosis versus standard practice: An open-label randomized controlled trial |
title_full |
The efficacy of honey and a Thai Herbal Oil preparation in the treatment of pressure ulcers based on Thai traditional medicine wound diagnosis versus standard practice: An open-label randomized controlled trial |
title_fullStr |
The efficacy of honey and a Thai Herbal Oil preparation in the treatment of pressure ulcers based on Thai traditional medicine wound diagnosis versus standard practice: An open-label randomized controlled trial |
title_full_unstemmed |
The efficacy of honey and a Thai Herbal Oil preparation in the treatment of pressure ulcers based on Thai traditional medicine wound diagnosis versus standard practice: An open-label randomized controlled trial |
title_sort |
efficacy of honey and a thai herbal oil preparation in the treatment of pressure ulcers based on thai traditional medicine wound diagnosis versus standard practice: an open-label randomized controlled trial |
publisher |
Elsevier |
series |
Contemporary Clinical Trials Communications |
issn |
2451-8654 |
publishDate |
2020-03-01 |
description |
Background: Scientific support for Thai traditional medicine (TTM) practice is warranted for reintroduction into modern healthcare systems. A promising TTM practice for treatment of pressure ulcers was selected to conduct a clinical trial. This study aimed to evaluate the efficacy of the TTM practice for the treatment of pressure ulcers using honey or a Thai Herbal Oil preparation (THO) based on the TTM wound diagnosis comparing with the standard practice. Methods: The study design was an open-label randomized controlled trial. Sixty-six participants, with pressure ulcers at least stage II-IV or unstageable, were allocated to two groups via minimization. A TTM practice group received honey or THO depending on the TTM diagnosis via the Thai Traditional Medicine Pressure Ulcer Assessment Tool (TTM-PUAT). A standard practice group received advanced dressings, including hydrogel, alginate, silver-impregnated, or hydrocolloid dressings. The primary outcome was the Pressure Ulcer Scale for Healing (PUSH). Results: Both TTM practice and standard practice showed a significant reduction in PUSH scores after treatments. However, there was no significant difference in PUSH score reduction between the groups. The mean PUSH score reduction over the 6-week period was 2.58 ± 3.38 (95% CI 1.34–3.82) in the TTM practice group and 3.24 ± 3.49 (95% CI 1.91–4.57) in the standard practice group (p = 0.284). The TTM practice and standard practice accelerated pressure ulcer healing without statistically significant difference between the practices, during 6 weeks in a home-based care setting. This finding supported the TTM practice as an alternative treatment for pressure ulcer. Keywords: Decubitus, Diagnosis, Honey, Clinacanthus nutans, Zingiber montanum, Traditional medicine |
url |
http://www.sciencedirect.com/science/article/pii/S2451865420300223 |
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