Association of the macrophage migration inhibitory factor promoter polymorphisms with benign lymphoepithelial lesion of lacrimal gland

AIM: To identify the association of the macrophage migration inhibitory factor (MIF) gene polymorphism with the susceptibility of benign lymphoepithelial lesions (BLEL) of the lacrimal gland. METHODS: A total of 40 BLEL of lacrimal gland cases were matched with 40 healthy subjects (HS). Extraction...

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Main Authors: Qin-Jian Li, Peng-Xiang Zhao, Xu-Juan Zhang, Yang Yi, Dan-Ying Cheng, Jian-Min Ma, Xue-Mei Ma
Format: Article
Language:English
Published: Press of International Journal of Ophthalmology (IJO PRESS) 2017-08-01
Series:International Journal of Ophthalmology
Subjects:
Online Access:http://www.ijo.cn/en_publish/2017/8/20170807.pdf
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spelling doaj-e04e28cb85ba467db4f47a8b1dee21a22020-11-25T02:47:38ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982017-08-011081229123210.18240/ijo.2017.08.07Association of the macrophage migration inhibitory factor promoter polymorphisms with benign lymphoepithelial lesion of lacrimal glandQin-Jian Li0Peng-Xiang Zhao1Xu-Juan Zhang2Yang Yi3Dan-Ying Cheng4Jian-Min Ma5Xue-Mei Ma6College of Life Science and Bio-engineering, Beijing University of Technology, Beijing 100124, ChinaCollege of Life Science and Bio-engineering, Beijing University of Technology, Beijing 100124, ChinaCollege of Life Science and Bio-engineering, Beijing University of Technology, Beijing 100124, ChinaCollege of Life Science and Bio-engineering, Beijing University of Technology, Beijing 100124, ChinaInstitute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, ChinaBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology &amp;Vision Science Key Lab, Beijing 100730, ChinaCollege of Life Science and Bio-engineering, Beijing University of Technology, Beijing 100124, ChinaAIM: To identify the association of the macrophage migration inhibitory factor (MIF) gene polymorphism with the susceptibility of benign lymphoepithelial lesions (BLEL) of the lacrimal gland. METHODS: A total of 40 BLEL of lacrimal gland cases were matched with 40 healthy subjects (HS). Extraction the plasma and whole blood DNA of patients of lacrimal gland BLEL and HS. Elisa and polymerase chain reaction was used to determine in plasma contents of MIF and MIF gene SNP-173G>C and STR -794 CATT(5-8) polymorphism, respectively. RESULTS: The MIF levels in plasma were significantly higher in patients with lacrimal gland BLEL versus HS (P<0.001). The -173 G>C MIF polymorphism was significantly associated with lacrimal gland BLEL, with a significantly higher frequency of the C allele in lacrimal gland BLEL patients compared with HS (OR=2.38, 95% CI=1.07-5.31, P=0.032), and the -173 C/x is more frequent in patients than in HS, P=0.037. Besides, we found that the carriage rate of the MIF -173C/x is associated with higher plasma levels of MIF in the BLEL of lacrimal gland. CONCLUSION: MIF -173G/C variants play an insidious role in susceptibility of BLEL of lacrimal gland. Otherwise, there is no statistically significant correlation exists between MIF-794 CATT (5-8) and BLEL of lacrimal gland.http://www.ijo.cn/en_publish/2017/8/20170807.pdf1232benign lymphoepithelial lesionlacrimal glandmacrophage migration inhibitory factorgene polymorphism
collection DOAJ
language English
format Article
sources DOAJ
author Qin-Jian Li
Peng-Xiang Zhao
Xu-Juan Zhang
Yang Yi
Dan-Ying Cheng
Jian-Min Ma
Xue-Mei Ma
spellingShingle Qin-Jian Li
Peng-Xiang Zhao
Xu-Juan Zhang
Yang Yi
Dan-Ying Cheng
Jian-Min Ma
Xue-Mei Ma
Association of the macrophage migration inhibitory factor promoter polymorphisms with benign lymphoepithelial lesion of lacrimal gland
International Journal of Ophthalmology
1232
benign lymphoepithelial lesion
lacrimal gland
macrophage migration inhibitory factor
gene polymorphism
author_facet Qin-Jian Li
Peng-Xiang Zhao
Xu-Juan Zhang
Yang Yi
Dan-Ying Cheng
Jian-Min Ma
Xue-Mei Ma
author_sort Qin-Jian Li
title Association of the macrophage migration inhibitory factor promoter polymorphisms with benign lymphoepithelial lesion of lacrimal gland
title_short Association of the macrophage migration inhibitory factor promoter polymorphisms with benign lymphoepithelial lesion of lacrimal gland
title_full Association of the macrophage migration inhibitory factor promoter polymorphisms with benign lymphoepithelial lesion of lacrimal gland
title_fullStr Association of the macrophage migration inhibitory factor promoter polymorphisms with benign lymphoepithelial lesion of lacrimal gland
title_full_unstemmed Association of the macrophage migration inhibitory factor promoter polymorphisms with benign lymphoepithelial lesion of lacrimal gland
title_sort association of the macrophage migration inhibitory factor promoter polymorphisms with benign lymphoepithelial lesion of lacrimal gland
publisher Press of International Journal of Ophthalmology (IJO PRESS)
series International Journal of Ophthalmology
issn 2222-3959
2227-4898
publishDate 2017-08-01
description AIM: To identify the association of the macrophage migration inhibitory factor (MIF) gene polymorphism with the susceptibility of benign lymphoepithelial lesions (BLEL) of the lacrimal gland. METHODS: A total of 40 BLEL of lacrimal gland cases were matched with 40 healthy subjects (HS). Extraction the plasma and whole blood DNA of patients of lacrimal gland BLEL and HS. Elisa and polymerase chain reaction was used to determine in plasma contents of MIF and MIF gene SNP-173G>C and STR -794 CATT(5-8) polymorphism, respectively. RESULTS: The MIF levels in plasma were significantly higher in patients with lacrimal gland BLEL versus HS (P<0.001). The -173 G>C MIF polymorphism was significantly associated with lacrimal gland BLEL, with a significantly higher frequency of the C allele in lacrimal gland BLEL patients compared with HS (OR=2.38, 95% CI=1.07-5.31, P=0.032), and the -173 C/x is more frequent in patients than in HS, P=0.037. Besides, we found that the carriage rate of the MIF -173C/x is associated with higher plasma levels of MIF in the BLEL of lacrimal gland. CONCLUSION: MIF -173G/C variants play an insidious role in susceptibility of BLEL of lacrimal gland. Otherwise, there is no statistically significant correlation exists between MIF-794 CATT (5-8) and BLEL of lacrimal gland.
topic 1232
benign lymphoepithelial lesion
lacrimal gland
macrophage migration inhibitory factor
gene polymorphism
url http://www.ijo.cn/en_publish/2017/8/20170807.pdf
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