IFNGR1 signaling is associated with adverse pregnancy outcomes during infection with malaria parasites.
Complicated/severe cases of placental pathology due to Plasmodium falciparum and P. vivax, especially adverse pregnancy outcomes during P. vivax infection, have been increasing in recent years. However, the pathogenesis of placental pathology during severe malaria is poorly understood, while respons...
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doaj-e0511ccbed0d4141bc1f8d385916934e2020-11-25T01:45:49ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-011211e018539210.1371/journal.pone.0185392IFNGR1 signaling is associated with adverse pregnancy outcomes during infection with malaria parasites.Mamoru NiikuraShin-Ichi InoueShoichiro MineoHiroko AsahiFumie KobayashiComplicated/severe cases of placental pathology due to Plasmodium falciparum and P. vivax, especially adverse pregnancy outcomes during P. vivax infection, have been increasing in recent years. However, the pathogenesis of placental pathology during severe malaria is poorly understood, while responses against IFN-γ are thought to be associated with adverse pregnancy outcomes. In the present study, we explored the role of IFN-γ receptor 1 (IFNGR1) signaling in placental pathology during severe malaria using luciferase-expressing rodent malaria parasites, P. berghei NK65 (PbNK65L). We detected luciferase activities in the lung, spleen, adipose tissue, and placenta in pregnant mice, suggesting that infected erythrocytes could accumulate in various organs during infection. Importantly, we found that fetal mortality in IFNGR1-deficient mice infected with PbNK65L parasites was much less than in infected wild type (WT) mice. Placental pathology was also improved in IFNGR1-deficient mice. In contrast, bioluminescence imaging showed that parasite accumulation in the placentas of IFNGR1-deficient pregnant mice was comparable to that in WT mice infected with PbNK65L. These findings suggest that IFNGR1 signaling plays a pivotal role in placental pathology and subsequent adverse pregnancy outcomes during severe malaria. Our findings may increase our understanding of how disease aggravation occurs during malaria during pregnancy.http://europepmc.org/articles/PMC5678718?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mamoru Niikura Shin-Ichi Inoue Shoichiro Mineo Hiroko Asahi Fumie Kobayashi |
spellingShingle |
Mamoru Niikura Shin-Ichi Inoue Shoichiro Mineo Hiroko Asahi Fumie Kobayashi IFNGR1 signaling is associated with adverse pregnancy outcomes during infection with malaria parasites. PLoS ONE |
author_facet |
Mamoru Niikura Shin-Ichi Inoue Shoichiro Mineo Hiroko Asahi Fumie Kobayashi |
author_sort |
Mamoru Niikura |
title |
IFNGR1 signaling is associated with adverse pregnancy outcomes during infection with malaria parasites. |
title_short |
IFNGR1 signaling is associated with adverse pregnancy outcomes during infection with malaria parasites. |
title_full |
IFNGR1 signaling is associated with adverse pregnancy outcomes during infection with malaria parasites. |
title_fullStr |
IFNGR1 signaling is associated with adverse pregnancy outcomes during infection with malaria parasites. |
title_full_unstemmed |
IFNGR1 signaling is associated with adverse pregnancy outcomes during infection with malaria parasites. |
title_sort |
ifngr1 signaling is associated with adverse pregnancy outcomes during infection with malaria parasites. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2017-01-01 |
description |
Complicated/severe cases of placental pathology due to Plasmodium falciparum and P. vivax, especially adverse pregnancy outcomes during P. vivax infection, have been increasing in recent years. However, the pathogenesis of placental pathology during severe malaria is poorly understood, while responses against IFN-γ are thought to be associated with adverse pregnancy outcomes. In the present study, we explored the role of IFN-γ receptor 1 (IFNGR1) signaling in placental pathology during severe malaria using luciferase-expressing rodent malaria parasites, P. berghei NK65 (PbNK65L). We detected luciferase activities in the lung, spleen, adipose tissue, and placenta in pregnant mice, suggesting that infected erythrocytes could accumulate in various organs during infection. Importantly, we found that fetal mortality in IFNGR1-deficient mice infected with PbNK65L parasites was much less than in infected wild type (WT) mice. Placental pathology was also improved in IFNGR1-deficient mice. In contrast, bioluminescence imaging showed that parasite accumulation in the placentas of IFNGR1-deficient pregnant mice was comparable to that in WT mice infected with PbNK65L. These findings suggest that IFNGR1 signaling plays a pivotal role in placental pathology and subsequent adverse pregnancy outcomes during severe malaria. Our findings may increase our understanding of how disease aggravation occurs during malaria during pregnancy. |
url |
http://europepmc.org/articles/PMC5678718?pdf=render |
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