Chemical combinations potentiate human pluripotent stem cell-derived 3D pancreatic progenitor clusters toward functional β cells

Human pluripotent stem cell (hPSC) derived pancreatic beta cells are a promising and potentially limitless source for cell replacement therapy. Here the authors perform stage-wise chemical screening to develop an improved protocol for hPSC differentiation to functional pancreatic beta cells at high...

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Main Authors:	Haisong Liu, Ronghui Li, Hsin-Kai Liao, Zheying Min, Chao Wang, Yang Yu, Lei Shi, Jiameng Dan, Alberto Hayek, Llanos Martinez Martinez, Estrella Nuñez Delicado, Juan Carlos Izpisua Belmonte
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-23525-x

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spelling	doaj-e0538b6a302e489391b9de003c23bba82021-06-13T11:17:19ZengNature Publishing GroupNature Communications2041-17232021-06-0112111010.1038/s41467-021-23525-xChemical combinations potentiate human pluripotent stem cell-derived 3D pancreatic progenitor clusters toward functional β cellsHaisong Liu0Ronghui Li1Hsin-Kai Liao2Zheying Min3Chao Wang4Yang Yu5Lei Shi6Jiameng Dan7Alberto Hayek8Llanos Martinez Martinez9Estrella Nuñez Delicado10Juan Carlos Izpisua Belmonte11Gene Expression Laboratory, The Salk Institute for Biological StudiesGene Expression Laboratory, The Salk Institute for Biological StudiesGene Expression Laboratory, The Salk Institute for Biological StudiesBeijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology and Key Laboratory of Assisted Reproduction, Ministry of Education, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third HospitalGene Expression Laboratory, The Salk Institute for Biological StudiesGene Expression Laboratory, The Salk Institute for Biological StudiesGene Expression Laboratory, The Salk Institute for Biological StudiesGene Expression Laboratory, The Salk Institute for Biological StudiesDepartment of Pediatrics, UCSD-Medical SchoolUniversidad Católica San Antonio de MurciaUniversidad Católica San Antonio de MurciaGene Expression Laboratory, The Salk Institute for Biological StudiesHuman pluripotent stem cell (hPSC) derived pancreatic beta cells are a promising and potentially limitless source for cell replacement therapy. Here the authors perform stage-wise chemical screening to develop an improved protocol for hPSC differentiation to functional pancreatic beta cells at high efficiency.https://doi.org/10.1038/s41467-021-23525-x
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Haisong Liu Ronghui Li Hsin-Kai Liao Zheying Min Chao Wang Yang Yu Lei Shi Jiameng Dan Alberto Hayek Llanos Martinez Martinez Estrella Nuñez Delicado Juan Carlos Izpisua Belmonte
spellingShingle	Haisong Liu Ronghui Li Hsin-Kai Liao Zheying Min Chao Wang Yang Yu Lei Shi Jiameng Dan Alberto Hayek Llanos Martinez Martinez Estrella Nuñez Delicado Juan Carlos Izpisua Belmonte Chemical combinations potentiate human pluripotent stem cell-derived 3D pancreatic progenitor clusters toward functional β cells Nature Communications
author_facet	Haisong Liu Ronghui Li Hsin-Kai Liao Zheying Min Chao Wang Yang Yu Lei Shi Jiameng Dan Alberto Hayek Llanos Martinez Martinez Estrella Nuñez Delicado Juan Carlos Izpisua Belmonte
author_sort	Haisong Liu
title	Chemical combinations potentiate human pluripotent stem cell-derived 3D pancreatic progenitor clusters toward functional β cells
title_short	Chemical combinations potentiate human pluripotent stem cell-derived 3D pancreatic progenitor clusters toward functional β cells
title_full	Chemical combinations potentiate human pluripotent stem cell-derived 3D pancreatic progenitor clusters toward functional β cells
title_fullStr	Chemical combinations potentiate human pluripotent stem cell-derived 3D pancreatic progenitor clusters toward functional β cells
title_full_unstemmed	Chemical combinations potentiate human pluripotent stem cell-derived 3D pancreatic progenitor clusters toward functional β cells
title_sort	chemical combinations potentiate human pluripotent stem cell-derived 3d pancreatic progenitor clusters toward functional β cells
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-06-01
description	Human pluripotent stem cell (hPSC) derived pancreatic beta cells are a promising and potentially limitless source for cell replacement therapy. Here the authors perform stage-wise chemical screening to develop an improved protocol for hPSC differentiation to functional pancreatic beta cells at high efficiency.
url	https://doi.org/10.1038/s41467-021-23525-x
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Chemical combinations potentiate human pluripotent stem cell-derived 3D pancreatic progenitor clusters toward functional β cells

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