The natural alkaloid Jerantinine B has activity in acute myeloid leukemia cells through a mechanism involving c-Jun

The natural alkaloid Jerantinine B has activity in acute myeloid leukemia cells through a mechanism involving c-Jun

Abstract Background Acute myeloid leukemia (AML) is a heterogenous hematological malignancy with poor long-term survival. New drugs which improve the outcome of AML patients are urgently required. In this work, the activity and mechanism of action of the cytotoxic indole alkaloid Jerantinine B (JB),...

Full description

Bibliographic Details
Main Authors: Hayaa Moeed Alhuthali, Tracey D. Bradshaw, Kuan-Hon Lim, Toh-Seok Kam, Claire H. Seedhouse
Format: Article
Language:English
Published: BMC 2020-07-01
Series:BMC Cancer
Subjects:
Acute myeloid leukemia
Jerantinine
c-Jun
reactive oxygen species
Online Access:http://link.springer.com/article/10.1186/s12885-020-07119-2

Internet

http://link.springer.com/article/10.1186/s12885-020-07119-2

Similar Items