Chemical-genetic profiling reveals limited cross-resistance between antimicrobial peptides with different modes of action
The genetics underlying bacterial susceptibility to antimicrobial peptides (AMPs) remain unclear. Here, using a genome-wide chemical-genetic approach, the authors map the diversity of resistance determinants across AMPs in Escherichia coli and provide evidence that cross-resistance is prevalent only...
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Nature Publishing Group
2019-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-13618-z |
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doaj-e0586b491c9a457fa943b36f2a4c75e92021-05-11T11:55:16ZengNature Publishing GroupNature Communications2041-17232019-12-0110111310.1038/s41467-019-13618-zChemical-genetic profiling reveals limited cross-resistance between antimicrobial peptides with different modes of actionBálint Kintses0Pramod K. Jangir1Gergely Fekete2Mónika Számel3Orsolya Méhi4Réka Spohn5Lejla Daruka6Ana Martins7Ali Hosseinnia8Alla Gagarinova9Sunyoung Kim10Sadhna Phanse11Bálint Csörgő12Ádám Györkei13Eszter Ari14Viktória Lázár15István Nagy16Mohan Babu17Csaba Pál18Balázs Papp19Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research CentreSynthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research CentreSynthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research CentreSynthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research CentreSynthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research CentreSynthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research CentreSynthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research CentreSynthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research CentreDepartment of Biochemistry, University of ReginaDepartment of Biochemistry, University of SaskatchewanDepartment of Biochemistry, University of ReginaDepartment of Biochemistry, University of ReginaSynthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research CentreSynthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research CentreSynthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research CentreSynthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research CentreSequencing Platform, Institute of Biochemistry, Biological Research CentreDepartment of Biochemistry, University of ReginaSynthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research CentreSynthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research CentreThe genetics underlying bacterial susceptibility to antimicrobial peptides (AMPs) remain unclear. Here, using a genome-wide chemical-genetic approach, the authors map the diversity of resistance determinants across AMPs in Escherichia coli and provide evidence that cross-resistance is prevalent only between AMPs with similar modes of action.https://doi.org/10.1038/s41467-019-13618-z |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Bálint Kintses Pramod K. Jangir Gergely Fekete Mónika Számel Orsolya Méhi Réka Spohn Lejla Daruka Ana Martins Ali Hosseinnia Alla Gagarinova Sunyoung Kim Sadhna Phanse Bálint Csörgő Ádám Györkei Eszter Ari Viktória Lázár István Nagy Mohan Babu Csaba Pál Balázs Papp |
| spellingShingle |
Bálint Kintses Pramod K. Jangir Gergely Fekete Mónika Számel Orsolya Méhi Réka Spohn Lejla Daruka Ana Martins Ali Hosseinnia Alla Gagarinova Sunyoung Kim Sadhna Phanse Bálint Csörgő Ádám Györkei Eszter Ari Viktória Lázár István Nagy Mohan Babu Csaba Pál Balázs Papp Chemical-genetic profiling reveals limited cross-resistance between antimicrobial peptides with different modes of action Nature Communications |
| author_facet |
Bálint Kintses Pramod K. Jangir Gergely Fekete Mónika Számel Orsolya Méhi Réka Spohn Lejla Daruka Ana Martins Ali Hosseinnia Alla Gagarinova Sunyoung Kim Sadhna Phanse Bálint Csörgő Ádám Györkei Eszter Ari Viktória Lázár István Nagy Mohan Babu Csaba Pál Balázs Papp |
| author_sort |
Bálint Kintses |
| title |
Chemical-genetic profiling reveals limited cross-resistance between antimicrobial peptides with different modes of action |
| title_short |
Chemical-genetic profiling reveals limited cross-resistance between antimicrobial peptides with different modes of action |
| title_full |
Chemical-genetic profiling reveals limited cross-resistance between antimicrobial peptides with different modes of action |
| title_fullStr |
Chemical-genetic profiling reveals limited cross-resistance between antimicrobial peptides with different modes of action |
| title_full_unstemmed |
Chemical-genetic profiling reveals limited cross-resistance between antimicrobial peptides with different modes of action |
| title_sort |
chemical-genetic profiling reveals limited cross-resistance between antimicrobial peptides with different modes of action |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-12-01 |
| description |
The genetics underlying bacterial susceptibility to antimicrobial peptides (AMPs) remain unclear. Here, using a genome-wide chemical-genetic approach, the authors map the diversity of resistance determinants across AMPs in Escherichia coli and provide evidence that cross-resistance is prevalent only between AMPs with similar modes of action. |
| url |
https://doi.org/10.1038/s41467-019-13618-z |
| work_keys_str_mv |
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