Sustained activation of the Aryl hydrocarbon Receptor transcription factor promotes resistance to BRAF-inhibitors in melanoma

Resistance to BRAF inhibitors limits their clinical benefit in melanoma patients. Here, the authors show that the Aryl hydrocarbon Receptor (AhR) is a key mediator of resistant genes and use resveratrol, an AhR antagonist, to revert resistance in melanoma bearing mice.

Bibliographic Details
Main Authors:	Sébastien Corre, Nina Tardif, Nicolas Mouchet, Héloïse M. Leclair, Lise Boussemart, Arthur Gautron, Laura Bachelot, Anthony Perrot, Anatoly Soshilov, Aljosja Rogiers, Florian Rambow, Erwan Dumontet, Karin Tarte, Alban Bessede, Gilles J. Guillemin, Jean-Christophe Marine, Michael S. Denison, David Gilot, Marie-Dominique Galibert
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-11-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-06951-2

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spelling	doaj-e059e48b1f30450aba786bdcd533d1462021-05-11T09:50:45ZengNature Publishing GroupNature Communications2041-17232018-11-019111310.1038/s41467-018-06951-2Sustained activation of the Aryl hydrocarbon Receptor transcription factor promotes resistance to BRAF-inhibitors in melanomaSébastien Corre0Nina Tardif1Nicolas Mouchet2Héloïse M. Leclair3Lise Boussemart4Arthur Gautron5Laura Bachelot6Anthony Perrot7Anatoly Soshilov8Aljosja Rogiers9Florian Rambow10Erwan Dumontet11Karin Tarte12Alban Bessede13Gilles J. Guillemin14Jean-Christophe Marine15Michael S. Denison16David Gilot17Marie-Dominique Galibert18IGDR (Institut de Génétique et Développement de Rennes)—UMR6290, CNRS, Univ RennesIGDR (Institut de Génétique et Développement de Rennes)—UMR6290, CNRS, Univ RennesIGDR (Institut de Génétique et Développement de Rennes)—UMR6290, CNRS, Univ RennesIGDR (Institut de Génétique et Développement de Rennes)—UMR6290, CNRS, Univ RennesIGDR (Institut de Génétique et Développement de Rennes)—UMR6290, CNRS, Univ RennesIGDR (Institut de Génétique et Développement de Rennes)—UMR6290, CNRS, Univ RennesIGDR (Institut de Génétique et Développement de Rennes)—UMR6290, CNRS, Univ RennesIGDR (Institut de Génétique et Développement de Rennes)—UMR6290, CNRS, Univ RennesDepartment of Environmental Toxicology, University of CaliforniaLaboratory for Molecular Cancer Biology, VIB Center for Cancer Biology, VIBLaboratory for Molecular Cancer Biology, VIB Center for Cancer Biology, VIBMICMAC (MIcroenvironment, Cell differentiation, iMmunology And Cancer)—UMR_S 1236, Inserm, Univ RennesMICMAC (MIcroenvironment, Cell differentiation, iMmunology And Cancer)—UMR_S 1236, Inserm, Univ RennesImmuSmolNeuroinflammation Group, MND and Neurodegenerative Diseases Research Center, Macquarie UniversityLaboratory for Molecular Cancer Biology, VIB Center for Cancer Biology, VIBDepartment of Environmental Toxicology, University of CaliforniaIGDR (Institut de Génétique et Développement de Rennes)—UMR6290, CNRS, Univ RennesIGDR (Institut de Génétique et Développement de Rennes)—UMR6290, CNRS, Univ RennesResistance to BRAF inhibitors limits their clinical benefit in melanoma patients. Here, the authors show that the Aryl hydrocarbon Receptor (AhR) is a key mediator of resistant genes and use resveratrol, an AhR antagonist, to revert resistance in melanoma bearing mice.https://doi.org/10.1038/s41467-018-06951-2
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Sébastien Corre Nina Tardif Nicolas Mouchet Héloïse M. Leclair Lise Boussemart Arthur Gautron Laura Bachelot Anthony Perrot Anatoly Soshilov Aljosja Rogiers Florian Rambow Erwan Dumontet Karin Tarte Alban Bessede Gilles J. Guillemin Jean-Christophe Marine Michael S. Denison David Gilot Marie-Dominique Galibert
spellingShingle	Sébastien Corre Nina Tardif Nicolas Mouchet Héloïse M. Leclair Lise Boussemart Arthur Gautron Laura Bachelot Anthony Perrot Anatoly Soshilov Aljosja Rogiers Florian Rambow Erwan Dumontet Karin Tarte Alban Bessede Gilles J. Guillemin Jean-Christophe Marine Michael S. Denison David Gilot Marie-Dominique Galibert Sustained activation of the Aryl hydrocarbon Receptor transcription factor promotes resistance to BRAF-inhibitors in melanoma Nature Communications
author_facet	Sébastien Corre Nina Tardif Nicolas Mouchet Héloïse M. Leclair Lise Boussemart Arthur Gautron Laura Bachelot Anthony Perrot Anatoly Soshilov Aljosja Rogiers Florian Rambow Erwan Dumontet Karin Tarte Alban Bessede Gilles J. Guillemin Jean-Christophe Marine Michael S. Denison David Gilot Marie-Dominique Galibert
author_sort	Sébastien Corre
title	Sustained activation of the Aryl hydrocarbon Receptor transcription factor promotes resistance to BRAF-inhibitors in melanoma
title_short	Sustained activation of the Aryl hydrocarbon Receptor transcription factor promotes resistance to BRAF-inhibitors in melanoma
title_full	Sustained activation of the Aryl hydrocarbon Receptor transcription factor promotes resistance to BRAF-inhibitors in melanoma
title_fullStr	Sustained activation of the Aryl hydrocarbon Receptor transcription factor promotes resistance to BRAF-inhibitors in melanoma
title_full_unstemmed	Sustained activation of the Aryl hydrocarbon Receptor transcription factor promotes resistance to BRAF-inhibitors in melanoma
title_sort	sustained activation of the aryl hydrocarbon receptor transcription factor promotes resistance to braf-inhibitors in melanoma
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-11-01
description	Resistance to BRAF inhibitors limits their clinical benefit in melanoma patients. Here, the authors show that the Aryl hydrocarbon Receptor (AhR) is a key mediator of resistant genes and use resveratrol, an AhR antagonist, to revert resistance in melanoma bearing mice.
url	https://doi.org/10.1038/s41467-018-06951-2
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Sustained activation of the Aryl hydrocarbon Receptor transcription factor promotes resistance to BRAF-inhibitors in melanoma

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