Dissemination of Mycobacterium tuberculosis is associated to a SIGLEC1 null variant that limits antigen exchange via trafficking extracellular vesicles

Dissemination of Mycobacterium tuberculosis is associated to a SIGLEC1 null variant that limits antigen exchange via trafficking extracellular vesicles

Abstract The identification of individuals with null alleles enables studying how the loss of gene function affects infection. We previously described a non‐functional variant in SIGLEC1, which encodes the myeloid‐cell receptor Siglec‐1/CD169 implicated in HIV‐1 cell‐to‐cell transmission. Here we re...

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Bibliographic Details
Main Authors: Susana Benet, Cristina Gálvez, Francis Drobniewski, Irina Kontsevaya, Lilibeth Arias, Marta Monguió‐Tortajada, Itziar Erkizia, Victor Urrea, Ruo‐Yan Ong, Marina Luquin, Maeva Dupont, Jakub Chojnacki, Judith Dalmau, Paula Cardona, Olivier Neyrolles, Geanncarlo Lugo‐Villarino, Christel Vérollet, Esther Julián, Hansjakob Furrer, Huldrych F. Günthard, Paul R. Crocker, Gustavo Tapia, Francesc E. Borràs, Jacques Fellay, Paul J. McLaren, Amalio Telenti, Pere‐Joan Cardona, Bonaventura Clotet, Cristina Vilaplana, Javier Martinez‐Picado, Nuria Izquierdo‐Useros
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Journal of Extracellular Vesicles
Subjects:
Extracellular vesicles
HIV‐1
Mtb
Siglec‐1
Online Access:https://doi.org/10.1002/jev2.12046

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