Curcumin Nanoparticles Protect against Isoproterenol Induced Myocardial Infarction by Alleviating Myocardial Tissue Oxidative Stress, Electrocardiogram, and Biological Changes
Curcumin from <i>Curcuma longa</i> is a nutraceutical compound reported to possess strong antioxidant activity that makes it a candidate for use in counteracting oxidative stress-induced damage. The effect of pre-treatment with curcumin nanoparticles (nC) compared to conventional curcumi...
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doaj-e06b8ed38c3943b8aab99660d467d6ba2020-11-25T02:16:52ZengMDPI AGMolecules1420-30492019-08-012415280210.3390/molecules24152802molecules24152802Curcumin Nanoparticles Protect against Isoproterenol Induced Myocardial Infarction by Alleviating Myocardial Tissue Oxidative Stress, Electrocardiogram, and Biological ChangesPaul-Mihai Boarescu0Ioana Boarescu1Ioana Corina Bocșan2Raluca Maria Pop3Dan Gheban4Adriana Elena Bulboacă5Cristina Nicula6Ruxandra-Mioara Râjnoveanu7Sorana D. Bolboacă8Department of Pathophysiology, Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca, Victor Babeş Street, no. 2-4, 400012 Cluj-Napoca, RomaniaDepartment of Neurology, County Clinical Emergency Hospital of Cluj-Napoca, Victor Babes Street, no 43, 400012 Cluj-Napoca, RomaniaDepartment of Pharmacology, Toxicology and Clinical Pharmacology, Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca, Gheorghe Marinescu Street, no 23, 400337 Cluj-Napoca, RomaniaDepartment of Pharmacology, Toxicology and Clinical Pharmacology, Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca, Gheorghe Marinescu Street, no 23, 400337 Cluj-Napoca, RomaniaDepartment of Pathological Anatomy, Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca, Clinicilor Street, no 3-5, 400006 Cluj-Napoca, RomaniaDepartment of Pathophysiology, Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca, Victor Babeş Street, no. 2-4, 400012 Cluj-Napoca, RomaniaDepartment of Ophthalmology, Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca, Clinicilor Street, no 3-5, 400006 Cluj-Napoca, RomaniaDepartment of Pneumology, Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca, B.P. Hasdeu Street, no. 6, 400371 Cluj-Napoca, RomaniaDepartment of Medical Informatics and Biostatistics, Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca, Louis Pasteur Street, no. 6, 400349 Cluj-Napoca, RomaniaCurcumin from <i>Curcuma longa</i> is a nutraceutical compound reported to possess strong antioxidant activity that makes it a candidate for use in counteracting oxidative stress-induced damage. The effect of pre-treatment with curcumin nanoparticles (nC) compared to conventional curcumin (Cs) on blood pressure, electrocardiogram, and biological changes on isoproterenol (ISO)-induced myocardial infarction (MI) in rats had been investigated. The Cs doses of 150 and 200 mg/kg bw and all nC doses (100, 150 and 200 mg/kg bw) significantly reduced heart rate before ISO administration and prevented QRS complex enlargement after MI induction (<i>p</i> < 0.026). All doses of Cs and nC prevented prolongation of the QT and QT corrected (QTc) intervals, with better results for higher doses (<i>p</i> < 0.048). The nC solution had more significant results than Cs in all metabolic parameters assessed (lactate dehydrogenase, glycaemia, aspartate transaminase, and alanine transaminase, <i>p</i> < 0.009). nC was more efficient than Cs in limiting myocardial oxidative stress and enhancing antioxidative capacity (<i>p</i> < 0.004). Compared to Cs, nC better prevented myocardial damage extension, reduced interstitial oedema, and inflammation. Curcumin nanoparticles as compared to conventional curcumin exert better antioxidative effects. Moreover, nC better prevent cardiomyocytes damage, and electrocardiogram alterations, in the case of ISO-induced MI in rats.https://www.mdpi.com/1420-3049/24/15/2802myocardial infarctioncurcuminnanoparticlesisoproterenoloxidative stress |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Paul-Mihai Boarescu Ioana Boarescu Ioana Corina Bocșan Raluca Maria Pop Dan Gheban Adriana Elena Bulboacă Cristina Nicula Ruxandra-Mioara Râjnoveanu Sorana D. Bolboacă |
spellingShingle |
Paul-Mihai Boarescu Ioana Boarescu Ioana Corina Bocșan Raluca Maria Pop Dan Gheban Adriana Elena Bulboacă Cristina Nicula Ruxandra-Mioara Râjnoveanu Sorana D. Bolboacă Curcumin Nanoparticles Protect against Isoproterenol Induced Myocardial Infarction by Alleviating Myocardial Tissue Oxidative Stress, Electrocardiogram, and Biological Changes Molecules myocardial infarction curcumin nanoparticles isoproterenol oxidative stress |
author_facet |
Paul-Mihai Boarescu Ioana Boarescu Ioana Corina Bocșan Raluca Maria Pop Dan Gheban Adriana Elena Bulboacă Cristina Nicula Ruxandra-Mioara Râjnoveanu Sorana D. Bolboacă |
author_sort |
Paul-Mihai Boarescu |
title |
Curcumin Nanoparticles Protect against Isoproterenol Induced Myocardial Infarction by Alleviating Myocardial Tissue Oxidative Stress, Electrocardiogram, and Biological Changes |
title_short |
Curcumin Nanoparticles Protect against Isoproterenol Induced Myocardial Infarction by Alleviating Myocardial Tissue Oxidative Stress, Electrocardiogram, and Biological Changes |
title_full |
Curcumin Nanoparticles Protect against Isoproterenol Induced Myocardial Infarction by Alleviating Myocardial Tissue Oxidative Stress, Electrocardiogram, and Biological Changes |
title_fullStr |
Curcumin Nanoparticles Protect against Isoproterenol Induced Myocardial Infarction by Alleviating Myocardial Tissue Oxidative Stress, Electrocardiogram, and Biological Changes |
title_full_unstemmed |
Curcumin Nanoparticles Protect against Isoproterenol Induced Myocardial Infarction by Alleviating Myocardial Tissue Oxidative Stress, Electrocardiogram, and Biological Changes |
title_sort |
curcumin nanoparticles protect against isoproterenol induced myocardial infarction by alleviating myocardial tissue oxidative stress, electrocardiogram, and biological changes |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2019-08-01 |
description |
Curcumin from <i>Curcuma longa</i> is a nutraceutical compound reported to possess strong antioxidant activity that makes it a candidate for use in counteracting oxidative stress-induced damage. The effect of pre-treatment with curcumin nanoparticles (nC) compared to conventional curcumin (Cs) on blood pressure, electrocardiogram, and biological changes on isoproterenol (ISO)-induced myocardial infarction (MI) in rats had been investigated. The Cs doses of 150 and 200 mg/kg bw and all nC doses (100, 150 and 200 mg/kg bw) significantly reduced heart rate before ISO administration and prevented QRS complex enlargement after MI induction (<i>p</i> < 0.026). All doses of Cs and nC prevented prolongation of the QT and QT corrected (QTc) intervals, with better results for higher doses (<i>p</i> < 0.048). The nC solution had more significant results than Cs in all metabolic parameters assessed (lactate dehydrogenase, glycaemia, aspartate transaminase, and alanine transaminase, <i>p</i> < 0.009). nC was more efficient than Cs in limiting myocardial oxidative stress and enhancing antioxidative capacity (<i>p</i> < 0.004). Compared to Cs, nC better prevented myocardial damage extension, reduced interstitial oedema, and inflammation. Curcumin nanoparticles as compared to conventional curcumin exert better antioxidative effects. Moreover, nC better prevent cardiomyocytes damage, and electrocardiogram alterations, in the case of ISO-induced MI in rats. |
topic |
myocardial infarction curcumin nanoparticles isoproterenol oxidative stress |
url |
https://www.mdpi.com/1420-3049/24/15/2802 |
work_keys_str_mv |
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