Anthelmintic acetogenin from Annona squamosa L. Seeds

Annona squamosa seeds extracts showed anthelmintic activity against Haemonchus contortus, the main nematode of sheep and goat in Northeastern Brazil. A compound 1 was isolated from ethyl acetate extract and inhibited the egg hatching of H. contortus at 25 mg ml-1. The structure of 1 was determined a...

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Bibliographic Details
Main Authors: Marta M.C. Souza, Claudia M.L. Bevilaqua, Selene M. Morais, Cícero T.C. Costa, Ana R.A. Silva, Raimundo Braz-Filho
Format: Article
Language:English
Published: Academia Brasileira de Ciências 2008-06-01
Series:Anais da Academia Brasileira de Ciências
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Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652008000200005
Description
Summary:Annona squamosa seeds extracts showed anthelmintic activity against Haemonchus contortus, the main nematode of sheep and goat in Northeastern Brazil. A compound 1 was isolated from ethyl acetate extract and inhibited the egg hatching of H. contortus at 25 mg ml-1. The structure of 1 was determined as a C37 trihydroxy adjacent bistetrahydrofuran acetogenin based on spectroscopic analysis.<br>Extratos das sementes de Annona squamosa demonstraram atividade anti-helmíntica contra Haemonchus contortus, o principal nematódeo de ovinos e caprinos no Nordeste do Brasil. O composto 1 foi isolado do extrato acetato de etila e inibiu a eclosão dos ovos de H. contortus a 25 mg ml-1. A estrutura de 1 foi determinada como uma acetogenina C37 tri-hidroxi bis-tetrahydrofurano adjacente, baseando-se nos dados espectrais.
ISSN:0001-3765
1678-2690