Intravitreal bevacizumab and Ahmed glaucoma valve implantation in patients with neovascular glaucoma
<b>AIM:</b>To explore the efficacy of preoperative intravitreal bevacizumab (IVB) injection combined with Ahmed glaucoma valve (AGV) implantation in the treatment of neovascular glaucoma (NVG).<b>METHODS:</b> This retrospective study included 35 eyes from 35 patients who unde...
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doaj-e07632d1ccde4abf89ad171e454aa1602020-11-25T00:08:48ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982014-10-017583784210.3980/j.issn.2222-3959.2014.05.18Intravitreal bevacizumab and Ahmed glaucoma valve implantation in patients with neovascular glaucomaHai-Tao Zhang0Yu-Xin Yang1Ying-Ying Xu2Rui-Min Yang3Bao-Jun Wang4Jun-Xi Hu5Department of Ophthalmology, the First Affiliated Hospital of Xinxiang Medical College, Xinxiang 453100, Henan Province, ChinaDepartment of Ophthalmology, the First Affiliated Hospital of Xinxiang Medical College, Xinxiang 453100, Henan Province, ChinaDepartment of Ophthalmology, the First Affiliated Hospital of Xinxiang Medical College, Xinxiang 453100, Henan Province, ChinaDepartment of Interventional Radiology, the First Affiliated Hospital of Xinxiang Medical College, Xinxiang 453100, Henan Province, ChinaDepartment of Ophthalmology, the First Affiliated Hospital of Xinxiang Medical College, Xinxiang 453100, Henan Province, ChinaDepartment of Ophthalmology, the First Affiliated Hospital of Xinxiang Medical College, Xinxiang 453100, Henan Province, China<b>AIM:</b>To explore the efficacy of preoperative intravitreal bevacizumab (IVB) injection combined with Ahmed glaucoma valve (AGV) implantation in the treatment of neovascular glaucoma (NVG).<b>METHODS:</b> This retrospective study included 35 eyes from 35 patients who underwent preoperative IVB and AGV implantation for treatment of NVG. Findings such as intraocular pressure (IOP) number of anti-glaucoma medications, visual acuity (VA), surgical success rates, and complications were recorded.<b>RESULTS:</b> After AGV implantation, IOP was 18.2±4.0 mm Hg, 15.5±3.3 mm Hg and 9.8±2.6 mm Hg at 6, 12 and 36mo, significantly decreased compared with pre-IOP (<i>P<</i>0.01). The number of anti-glaucoma medications was 0.9±0.5, 0.8±0.9 and 0.8±0.6 at 6, 12 and 36mo, significantly decreased compared to pre-treatment (<i>P<</i>0.01). At last visit, there were 19 eyes with stable VA, 4 with VA improvement, 12 with diminished VA and 3 with complete loss light perception. There were 7 cases that failed during 3-year fellow up period. Cumulative probabilities of valve survival by Kaplan-Meier analysis were 82.9%, 74.1% and 71.0% at 12, 24 and 36mo, respectively. Cox stepwise regression analysis found that the survival time was significant associated with the pre-visual acuity <2/400 (<i>P<</i>0.05). Post-operative complications occurred in 8 eyes, of which hyphema presented in 2 eyes, choroidal effusion in 2 eyes.<b>CONCLUSION:</b> The procedure of preoperative IVB and AGV implantation should be one of treatments for NVG because of its safety and effectiveness.http://www.ijo.cn/en_publish/2014/5/20140518.pdfAhmed glaucoma valvebevacizumabintravitreal injectionneovascular glaucomaneovascular glaucoma |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hai-Tao Zhang Yu-Xin Yang Ying-Ying Xu Rui-Min Yang Bao-Jun Wang Jun-Xi Hu |
spellingShingle |
Hai-Tao Zhang Yu-Xin Yang Ying-Ying Xu Rui-Min Yang Bao-Jun Wang Jun-Xi Hu Intravitreal bevacizumab and Ahmed glaucoma valve implantation in patients with neovascular glaucoma International Journal of Ophthalmology Ahmed glaucoma valve bevacizumab intravitreal injection neovascular glaucoma neovascular glaucoma |
author_facet |
Hai-Tao Zhang Yu-Xin Yang Ying-Ying Xu Rui-Min Yang Bao-Jun Wang Jun-Xi Hu |
author_sort |
Hai-Tao Zhang |
title |
Intravitreal bevacizumab and Ahmed glaucoma valve implantation in patients with neovascular glaucoma |
title_short |
Intravitreal bevacizumab and Ahmed glaucoma valve implantation in patients with neovascular glaucoma |
title_full |
Intravitreal bevacizumab and Ahmed glaucoma valve implantation in patients with neovascular glaucoma |
title_fullStr |
Intravitreal bevacizumab and Ahmed glaucoma valve implantation in patients with neovascular glaucoma |
title_full_unstemmed |
Intravitreal bevacizumab and Ahmed glaucoma valve implantation in patients with neovascular glaucoma |
title_sort |
intravitreal bevacizumab and ahmed glaucoma valve implantation in patients with neovascular glaucoma |
publisher |
Press of International Journal of Ophthalmology (IJO PRESS) |
series |
International Journal of Ophthalmology |
issn |
2222-3959 2227-4898 |
publishDate |
2014-10-01 |
description |
<b>AIM:</b>To explore the efficacy of preoperative intravitreal bevacizumab (IVB) injection combined with Ahmed glaucoma valve (AGV) implantation in the treatment of neovascular glaucoma (NVG).<b>METHODS:</b> This retrospective study included 35 eyes from 35 patients who underwent preoperative IVB and AGV implantation for treatment of NVG. Findings such as intraocular pressure (IOP) number of anti-glaucoma medications, visual acuity (VA), surgical success rates, and complications were recorded.<b>RESULTS:</b> After AGV implantation, IOP was 18.2±4.0 mm Hg, 15.5±3.3 mm Hg and 9.8±2.6 mm Hg at 6, 12 and 36mo, significantly decreased compared with pre-IOP (<i>P<</i>0.01). The number of anti-glaucoma medications was 0.9±0.5, 0.8±0.9 and 0.8±0.6 at 6, 12 and 36mo, significantly decreased compared to pre-treatment (<i>P<</i>0.01). At last visit, there were 19 eyes with stable VA, 4 with VA improvement, 12 with diminished VA and 3 with complete loss light perception. There were 7 cases that failed during 3-year fellow up period. Cumulative probabilities of valve survival by Kaplan-Meier analysis were 82.9%, 74.1% and 71.0% at 12, 24 and 36mo, respectively. Cox stepwise regression analysis found that the survival time was significant associated with the pre-visual acuity <2/400 (<i>P<</i>0.05). Post-operative complications occurred in 8 eyes, of which hyphema presented in 2 eyes, choroidal effusion in 2 eyes.<b>CONCLUSION:</b> The procedure of preoperative IVB and AGV implantation should be one of treatments for NVG because of its safety and effectiveness. |
topic |
Ahmed glaucoma valve bevacizumab intravitreal injection neovascular glaucoma neovascular glaucoma |
url |
http://www.ijo.cn/en_publish/2014/5/20140518.pdf |
work_keys_str_mv |
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