Cytochrome P450 2U1 Is a Novel Independent Prognostic Biomarker in Breast Cancer Patients
Background: The susceptibility of breast cancer is largely affected by the metabolic capacity of breast tissue. This ability depends in part on the expression profile of cytochrome P450 (CYPs). CYPs are a superfamily of enzymes with related catalysis to endogenous and exogenous bioactive substances,...
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doaj-e07768a72c13411fb16a502841f9255e2020-11-25T02:59:25ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-08-011010.3389/fonc.2020.01379549235Cytochrome P450 2U1 Is a Novel Independent Prognostic Biomarker in Breast Cancer PatientsBin Luo0Chuang Chen1Xiaoyan Wu2Dandan Yan3Fangfang Chen4Xinxin Yu5Jingping Yuan6Department of Pathology, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Pathology, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Pathology, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Pathology, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Pathology, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Pathology, Renmin Hospital of Wuhan University, Wuhan, ChinaBackground: The susceptibility of breast cancer is largely affected by the metabolic capacity of breast tissue. This ability depends in part on the expression profile of cytochrome P450 (CYPs). CYPs are a superfamily of enzymes with related catalysis to endogenous and exogenous bioactive substances, including xenobiotic metabolism, drugs, and some endogenous substances metabolism which activate cells and stimulate cell signaling pathways, such as arachidonic acid metabolism, steroid metabolism, fatty acid metabolism. Interestingly, CYP was electively expressed in different tumors, and mediated the metabolic activation of multiple carcinogens and participated in the activation and deactivation of tumor therapeutic drugs. However, the biological action of cytochrome P450 2U1 (CYP2U1) in breast carcinoma is little understood so far.Methods: To investigate the biological value of CYP2U1 in breast carcinoma, we performed immunohistochemical (IHC) analysis and survival analysis based on clinico-pathological data of breast cancer.Results: IHC analysis showed that the abundance of CYP2U1 protein was inversely proportional to the state of estrogen receptor(ER) (P < 0.05), and the lower the degree of tumor differentiation, the higher the protein abundance (P < 0.001). Additionally, compared with luminal tumors, the CYP2U1 protein content was more abundant in triple negative breast cancer (P < 0.05). Importantly, survival analysis showed that higher CYP2U1 protein levels predicted poor 5-year overall survival rate (P < 0.01), 5-year disease-free survival rate (P < 0.05), and 5-year metastatic-free survival rate (P < 0.01) for the entire enrolled breast cancer patients.Conclusions: CYP2U1 is generally closely related to the clinicopathological characteristics and is also an adverse prognostic factor for breast carcinoma patients, indicating that CYP2U1 is engaged in the malignant progression of breast carcinoma.https://www.frontiersin.org/article/10.3389/fonc.2020.01379/fullcytochrome P450 2U1breast cancerprognostic biomarkerdisease-free survivaloverall survival |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bin Luo Chuang Chen Xiaoyan Wu Dandan Yan Fangfang Chen Xinxin Yu Jingping Yuan |
spellingShingle |
Bin Luo Chuang Chen Xiaoyan Wu Dandan Yan Fangfang Chen Xinxin Yu Jingping Yuan Cytochrome P450 2U1 Is a Novel Independent Prognostic Biomarker in Breast Cancer Patients Frontiers in Oncology cytochrome P450 2U1 breast cancer prognostic biomarker disease-free survival overall survival |
author_facet |
Bin Luo Chuang Chen Xiaoyan Wu Dandan Yan Fangfang Chen Xinxin Yu Jingping Yuan |
author_sort |
Bin Luo |
title |
Cytochrome P450 2U1 Is a Novel Independent Prognostic Biomarker in Breast Cancer Patients |
title_short |
Cytochrome P450 2U1 Is a Novel Independent Prognostic Biomarker in Breast Cancer Patients |
title_full |
Cytochrome P450 2U1 Is a Novel Independent Prognostic Biomarker in Breast Cancer Patients |
title_fullStr |
Cytochrome P450 2U1 Is a Novel Independent Prognostic Biomarker in Breast Cancer Patients |
title_full_unstemmed |
Cytochrome P450 2U1 Is a Novel Independent Prognostic Biomarker in Breast Cancer Patients |
title_sort |
cytochrome p450 2u1 is a novel independent prognostic biomarker in breast cancer patients |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2020-08-01 |
description |
Background: The susceptibility of breast cancer is largely affected by the metabolic capacity of breast tissue. This ability depends in part on the expression profile of cytochrome P450 (CYPs). CYPs are a superfamily of enzymes with related catalysis to endogenous and exogenous bioactive substances, including xenobiotic metabolism, drugs, and some endogenous substances metabolism which activate cells and stimulate cell signaling pathways, such as arachidonic acid metabolism, steroid metabolism, fatty acid metabolism. Interestingly, CYP was electively expressed in different tumors, and mediated the metabolic activation of multiple carcinogens and participated in the activation and deactivation of tumor therapeutic drugs. However, the biological action of cytochrome P450 2U1 (CYP2U1) in breast carcinoma is little understood so far.Methods: To investigate the biological value of CYP2U1 in breast carcinoma, we performed immunohistochemical (IHC) analysis and survival analysis based on clinico-pathological data of breast cancer.Results: IHC analysis showed that the abundance of CYP2U1 protein was inversely proportional to the state of estrogen receptor(ER) (P < 0.05), and the lower the degree of tumor differentiation, the higher the protein abundance (P < 0.001). Additionally, compared with luminal tumors, the CYP2U1 protein content was more abundant in triple negative breast cancer (P < 0.05). Importantly, survival analysis showed that higher CYP2U1 protein levels predicted poor 5-year overall survival rate (P < 0.01), 5-year disease-free survival rate (P < 0.05), and 5-year metastatic-free survival rate (P < 0.01) for the entire enrolled breast cancer patients.Conclusions: CYP2U1 is generally closely related to the clinicopathological characteristics and is also an adverse prognostic factor for breast carcinoma patients, indicating that CYP2U1 is engaged in the malignant progression of breast carcinoma. |
topic |
cytochrome P450 2U1 breast cancer prognostic biomarker disease-free survival overall survival |
url |
https://www.frontiersin.org/article/10.3389/fonc.2020.01379/full |
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