Connexins and Pannexins in Vascular Function and Disease
Connexins (Cxs) and pannexins (Panxs) are ubiquitous membrane channel forming proteins that are critically involved in many aspects of vascular physiology and pathology. The permeation of ions and small metabolites through Panx channels, Cx hemichannels and gap junction channels confers a crucial ro...
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doaj-e08d2853faa34a8bafcd07b15e957b462020-11-24T21:41:08ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-06-01196166310.3390/ijms19061663ijms19061663Connexins and Pannexins in Vascular Function and DiseaseFilippo Molica0Xavier F. Figueroa1Brenda R. Kwak2Brant E. Isakson3Jonathan M. Gibbins4Department of Pathology and Immunology, University of Geneva, CH-1211 Geneva, SwitzerlandDepartamento de Fisiología, Faculdad de Ciencias Biológicas, Pontifica Universidad Católica de Chile, Santiago 8330025, ChileDepartment of Pathology and Immunology, University of Geneva, CH-1211 Geneva, SwitzerlandRobert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USAInstitute for Cardiovascular & Metabolic Research, School of Biological Sciences, Harborne Building, University of Reading, Reading RG6 6AS, UKConnexins (Cxs) and pannexins (Panxs) are ubiquitous membrane channel forming proteins that are critically involved in many aspects of vascular physiology and pathology. The permeation of ions and small metabolites through Panx channels, Cx hemichannels and gap junction channels confers a crucial role to these proteins in intercellular communication and in maintaining tissue homeostasis. This review provides an overview of current knowledge with respect to the pathophysiological role of these channels in large arteries, the microcirculation, veins, the lymphatic system and platelet function. The essential nature of these membrane proteins in vascular homeostasis is further emphasized by the pathologies that are linked to mutations and polymorphisms in Cx and Panx genes.http://www.mdpi.com/1422-0067/19/6/1663connexinpannexinvascular physiologyvascular disease |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Filippo Molica Xavier F. Figueroa Brenda R. Kwak Brant E. Isakson Jonathan M. Gibbins |
spellingShingle |
Filippo Molica Xavier F. Figueroa Brenda R. Kwak Brant E. Isakson Jonathan M. Gibbins Connexins and Pannexins in Vascular Function and Disease International Journal of Molecular Sciences connexin pannexin vascular physiology vascular disease |
author_facet |
Filippo Molica Xavier F. Figueroa Brenda R. Kwak Brant E. Isakson Jonathan M. Gibbins |
author_sort |
Filippo Molica |
title |
Connexins and Pannexins in Vascular Function and Disease |
title_short |
Connexins and Pannexins in Vascular Function and Disease |
title_full |
Connexins and Pannexins in Vascular Function and Disease |
title_fullStr |
Connexins and Pannexins in Vascular Function and Disease |
title_full_unstemmed |
Connexins and Pannexins in Vascular Function and Disease |
title_sort |
connexins and pannexins in vascular function and disease |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2018-06-01 |
description |
Connexins (Cxs) and pannexins (Panxs) are ubiquitous membrane channel forming proteins that are critically involved in many aspects of vascular physiology and pathology. The permeation of ions and small metabolites through Panx channels, Cx hemichannels and gap junction channels confers a crucial role to these proteins in intercellular communication and in maintaining tissue homeostasis. This review provides an overview of current knowledge with respect to the pathophysiological role of these channels in large arteries, the microcirculation, veins, the lymphatic system and platelet function. The essential nature of these membrane proteins in vascular homeostasis is further emphasized by the pathologies that are linked to mutations and polymorphisms in Cx and Panx genes. |
topic |
connexin pannexin vascular physiology vascular disease |
url |
http://www.mdpi.com/1422-0067/19/6/1663 |
work_keys_str_mv |
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