Neonates with coronavirus disease 2019 acquired from infected mothers: the incompatibility of maternal intensity and infant lung involvement: two case reports

• Main Authors: Somayeh Moeindarbary, Azam Pourhoseini, Parvaneh Layegh, Zahra Shahriari, Faezeh Fayyaz, Milad Bahrami, Mahdi Rafiee
• Format: Article
• Language: English
• Published: BMC 2021-05-01
• Series: Journal of Medical Case Reports
• Subjects: Vertical transmission; COVID-19; Case report; Neonates; Maternal–fetal transmission
• Online Access: https://doi.org/10.1186/s13256-021-02698-5

Abstract Background The outbreak of coronavirus disease 2019 (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was declared a public health emergency by the World Health Organization on January 30, 2020. The results of recent studies have suggested that neonates may present symptoms of COVID-19. Although the presentation of the disease in neonates is known to vary, only a limited number of studies have investigated newborns infected with COVID-19. Case presentation This study presents two Asian cases of newborns with COVID-19. Maternal–fetal or postnatal transmission was suggested based on the simultaneity of maternal infection. Chest radiography in one of the neonates showed severe lung involvement. Despite support and resuscitation attempts, the poor clinical condition of the neonate led to his death. However, the two mothers and one of the neonates were discharged from the hospital in good general condition. Conclusion The neonates had worse clinical conditions than the mothers, and the intensity of pneumonia and level of lung involvement in the newborns were not associated with the stage and severity of the disease in the mothers with COVID-19.