A Cytotoxic Compound from n-Hexane Fraction of Lantana camara Linn Leaves

A Cytotoxic Compound from n-Hexane Fraction of Lantana camara Linn Leaves

In this study, one triterpenoid compound from n-hexane fraction of Lantana camaraLinn leaves has cytotoxic activity was isolated. Isolation was carried out using gravity chromatographycolumnand purification by recrystallization method. Isolated compound was obtained white solid with melting point 25...

Full description

Bibliographic Details
Main Authors: Suryati Suryati, Yuni Malasari, Mai Efdi, Elida Mardiah
Format: Article
Language:English
Published: Jenderal Soedirman University 2019-06-01
Series:Molekul
Online Access:https://ojs.jmolekul.com/ojs/index.php/jm/article/view/477
id doaj-e09054c274f74a0e9cf7f4ce8baf9ae0
record_format Article
spelling doaj-e09054c274f74a0e9cf7f4ce8baf9ae02020-11-24T23:54:38ZengJenderal Soedirman UniversityMolekul1907-97612019-06-01141313610.20884/1.jm.2019.14.1.477267A Cytotoxic Compound from n-Hexane Fraction of Lantana camara Linn LeavesSuryati Suryati0Yuni MalasariMai EfdiElida MardiahAndalas UniversityIn this study, one triterpenoid compound from n-hexane fraction of Lantana camaraLinn leaves has cytotoxic activity was isolated. Isolation was carried out using gravity chromatographycolumnand purification by recrystallization method. Isolated compound was obtained white solid with melting point 252-253oC. The structure of isolated compound was elucidated using spectroscopic analysis Ultraviolet (UV), Infrared (IR), 1H-Nuclear Magnetic Resonance (1H-NMR), 13C-Nuclear Magnetic Resonance (13C-NMR) Heteronuclear Multiple Bond Connectivity (HMBC),  Heteronuclear Multiple Quantum Correlation (HMQC), Distortionless Enhancement Polarization Transfer (DEPT) and comparative literature data, identified as Lantadene A (22β-angeloyloxy-3-oxoolean-12-en-28-oic-acid) with molecule formula C35H52O5. The Lantadene A compound was evaluated for cytotoxic activity against shrimp larvae Artemia SalinaLeach using Brine Shrimp Lethality Test(BSLT) method, showed strong cytotoxic activity with an LC50value of 48.97 µg/mL.https://ojs.jmolekul.com/ojs/index.php/jm/article/view/477
collection DOAJ
language English
format Article
sources DOAJ
author Suryati Suryati
Yuni Malasari
Mai Efdi
Elida Mardiah
spellingShingle Suryati Suryati
Yuni Malasari
Mai Efdi
Elida Mardiah
A Cytotoxic Compound from n-Hexane Fraction of Lantana camara Linn Leaves
Molekul
author_facet Suryati Suryati
Yuni Malasari
Mai Efdi
Elida Mardiah
author_sort Suryati Suryati
title A Cytotoxic Compound from n-Hexane Fraction of Lantana camara Linn Leaves
title_short A Cytotoxic Compound from n-Hexane Fraction of Lantana camara Linn Leaves
title_full A Cytotoxic Compound from n-Hexane Fraction of Lantana camara Linn Leaves
title_fullStr A Cytotoxic Compound from n-Hexane Fraction of Lantana camara Linn Leaves
title_full_unstemmed A Cytotoxic Compound from n-Hexane Fraction of Lantana camara Linn Leaves
title_sort cytotoxic compound from n-hexane fraction of lantana camara linn leaves
publisher Jenderal Soedirman University
series Molekul
issn 1907-9761
publishDate 2019-06-01
description In this study, one triterpenoid compound from n-hexane fraction of Lantana camaraLinn leaves has cytotoxic activity was isolated. Isolation was carried out using gravity chromatographycolumnand purification by recrystallization method. Isolated compound was obtained white solid with melting point 252-253oC. The structure of isolated compound was elucidated using spectroscopic analysis Ultraviolet (UV), Infrared (IR), 1H-Nuclear Magnetic Resonance (1H-NMR), 13C-Nuclear Magnetic Resonance (13C-NMR) Heteronuclear Multiple Bond Connectivity (HMBC),  Heteronuclear Multiple Quantum Correlation (HMQC), Distortionless Enhancement Polarization Transfer (DEPT) and comparative literature data, identified as Lantadene A (22β-angeloyloxy-3-oxoolean-12-en-28-oic-acid) with molecule formula C35H52O5. The Lantadene A compound was evaluated for cytotoxic activity against shrimp larvae Artemia SalinaLeach using Brine Shrimp Lethality Test(BSLT) method, showed strong cytotoxic activity with an LC50value of 48.97 µg/mL.
url https://ojs.jmolekul.com/ojs/index.php/jm/article/view/477
work_keys_str_mv AT suryatisuryati acytotoxiccompoundfromnhexanefractionoflantanacamaralinnleaves
AT yunimalasari acytotoxiccompoundfromnhexanefractionoflantanacamaralinnleaves
AT maiefdi acytotoxiccompoundfromnhexanefractionoflantanacamaralinnleaves
AT elidamardiah acytotoxiccompoundfromnhexanefractionoflantanacamaralinnleaves
AT suryatisuryati cytotoxiccompoundfromnhexanefractionoflantanacamaralinnleaves
AT yunimalasari cytotoxiccompoundfromnhexanefractionoflantanacamaralinnleaves
AT maiefdi cytotoxiccompoundfromnhexanefractionoflantanacamaralinnleaves
AT elidamardiah cytotoxiccompoundfromnhexanefractionoflantanacamaralinnleaves
_version_ 1725465553289609216

Similar Items