Case Report: MDM4 Amplified in a Thymoma Patient With Autoimmune Enteropathy and Myocarditis
IntroductionThymoma is a type of mediastinal malignant tumors which always associated with autoimmune diseases. Although surgery is the predominant treatment method for thymoma, the pathogenesis of thymoma and thymoma-associated autoimmune diseases is still unknown. However, the case study here prov...
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doaj-e090a8ddb94e416eb7232f05c764384a2021-05-13T09:06:37ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922021-05-011210.3389/fendo.2021.661316661316Case Report: MDM4 Amplified in a Thymoma Patient With Autoimmune Enteropathy and MyocarditisXin DuLei YuFei LiZhen YuXing-guo YangYu-xuan JiangXin-tao YuIntroductionThymoma is a type of mediastinal malignant tumors which always associated with autoimmune diseases. Although surgery is the predominant treatment method for thymoma, the pathogenesis of thymoma and thymoma-associated autoimmune diseases is still unknown. However, the case study here provided a possible pathogenesis and treatment to cure the thymoma with autoimmune enteropathy and myocarditis.Case presentationA thymoma case with autoimmune enteropathy and myocarditis undergoing surgery was reported. The symptoms and laboratory results of the patient had dramatically fluctuated after tumor resection and gradually alleviated. The whole exome sequencing found MDM4 amplified in tumor cells. Immunohistochemistry indicated that thymoma cells were positive for MDM4. The result of drug sensitivity tests showed thymoma cells were highly sensitive to Nutlin-3a.ConclusionMDM4 could play an important role in the pathogenesis of this thymoma case with autoimmune enteropathy and myocarditis. This discovery may provide a novel idea of pathogenesis and treatment for thymoma and autoimmune diseases.https://www.frontiersin.org/articles/10.3389/fendo.2021.661316/fullthymomaautoimmune enteropathyautoimmune myocarditisMDM4whole exome sequencingimmunohistochemistry |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xin Du Lei Yu Fei Li Zhen Yu Xing-guo Yang Yu-xuan Jiang Xin-tao Yu |
spellingShingle |
Xin Du Lei Yu Fei Li Zhen Yu Xing-guo Yang Yu-xuan Jiang Xin-tao Yu Case Report: MDM4 Amplified in a Thymoma Patient With Autoimmune Enteropathy and Myocarditis Frontiers in Endocrinology thymoma autoimmune enteropathy autoimmune myocarditis MDM4 whole exome sequencing immunohistochemistry |
author_facet |
Xin Du Lei Yu Fei Li Zhen Yu Xing-guo Yang Yu-xuan Jiang Xin-tao Yu |
author_sort |
Xin Du |
title |
Case Report: MDM4 Amplified in a Thymoma Patient With Autoimmune Enteropathy and Myocarditis |
title_short |
Case Report: MDM4 Amplified in a Thymoma Patient With Autoimmune Enteropathy and Myocarditis |
title_full |
Case Report: MDM4 Amplified in a Thymoma Patient With Autoimmune Enteropathy and Myocarditis |
title_fullStr |
Case Report: MDM4 Amplified in a Thymoma Patient With Autoimmune Enteropathy and Myocarditis |
title_full_unstemmed |
Case Report: MDM4 Amplified in a Thymoma Patient With Autoimmune Enteropathy and Myocarditis |
title_sort |
case report: mdm4 amplified in a thymoma patient with autoimmune enteropathy and myocarditis |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Endocrinology |
issn |
1664-2392 |
publishDate |
2021-05-01 |
description |
IntroductionThymoma is a type of mediastinal malignant tumors which always associated with autoimmune diseases. Although surgery is the predominant treatment method for thymoma, the pathogenesis of thymoma and thymoma-associated autoimmune diseases is still unknown. However, the case study here provided a possible pathogenesis and treatment to cure the thymoma with autoimmune enteropathy and myocarditis.Case presentationA thymoma case with autoimmune enteropathy and myocarditis undergoing surgery was reported. The symptoms and laboratory results of the patient had dramatically fluctuated after tumor resection and gradually alleviated. The whole exome sequencing found MDM4 amplified in tumor cells. Immunohistochemistry indicated that thymoma cells were positive for MDM4. The result of drug sensitivity tests showed thymoma cells were highly sensitive to Nutlin-3a.ConclusionMDM4 could play an important role in the pathogenesis of this thymoma case with autoimmune enteropathy and myocarditis. This discovery may provide a novel idea of pathogenesis and treatment for thymoma and autoimmune diseases. |
topic |
thymoma autoimmune enteropathy autoimmune myocarditis MDM4 whole exome sequencing immunohistochemistry |
url |
https://www.frontiersin.org/articles/10.3389/fendo.2021.661316/full |
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