Lead-induced gut injuries and the dietary protective strategies: A review

Lead-induced gut injuries and the dietary protective strategies: A review

Recently, a bidirectional relationship between dietary lead (Pb) exposure and gut changes has been identified. Pb causes gut dysbacteriosis and destroys gut physiological homeostasis, causing a series of oxidative stress, immune-inflammatory reactions and increased permeability of the intestinal bar...

Full description

Bibliographic Details
Main Authors: Leilei Yu, Yaqi Yu, Yue Xiao, Fengwei Tian, Arjan Narbad, Qixiao Zhai, Wei Chen
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Journal of Functional Foods
Subjects:
Lead
Gut microbiota
Gut physiology
Gut disorders
Dietary supplement
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464621001778
id doaj-e0a08308cb674a09a052a204af36df5d
record_format Article
spelling doaj-e0a08308cb674a09a052a204af36df5d2021-06-19T04:53:20ZengElsevierJournal of Functional Foods1756-46462021-08-0183104528Lead-induced gut injuries and the dietary protective strategies: A reviewLeilei Yu0Yaqi Yu1Yue Xiao2Fengwei Tian3Arjan Narbad4Qixiao Zhai5Wei Chen6State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; International Joint Research Laboratory for Probiotics at Jiangnan University, Wuxi, Jiangsu 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; International Joint Research Laboratory for Probiotics at Jiangnan University, Wuxi, Jiangsu 214122, China; (Yangzhou) Institute of Food Biotechnology, Jiangnan University, Yangzhou 225004, China; Corresponding authors at: State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.International Joint Research Laboratory for Probiotics at Jiangnan University, Wuxi, Jiangsu 214122, China; Gut Health and Microbiome Institute Strategic Programme, Quadram Institute Bioscience, Norwich 16 NR4 7UQ, UKState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; International Joint Research Laboratory for Probiotics at Jiangnan University, Wuxi, Jiangsu 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; International Joint Research Laboratory for Probiotics at Jiangnan University, Wuxi, Jiangsu 214122, China; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, Jiangsu 214122, China; Beijing Innovation Centre of Food Nutrition and Human Health, Beijing Technology & Business University, Beijing 100048, China; Corresponding authors at: State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.Recently, a bidirectional relationship between dietary lead (Pb) exposure and gut changes has been identified. Pb causes gut dysbacteriosis and destroys gut physiological homeostasis, causing a series of oxidative stress, immune-inflammatory reactions and increased permeability of the intestinal barrier. Pb-induced gut dysbiosis and physiological disorders are related to impairments in nutrient absorption, essential element homeostasis, lipid metabolism, and nervous system, which can in turn influence Pb transport and metabolism. Dietary supplements such as probiotics, prebiotics, minerals, and antioxidants could be a potential strategy to alleviate Pb toxicity. They can protect the gut barrier, promote Pb discharge, and regulate oxidative stress and essential metal levels, which likely depend on the gut microbiota. Thus, dietary supplements, especially probiotics and prebiotics, are a new and safe strategy to prevent and alleviate Pb poisoning in the future.http://www.sciencedirect.com/science/article/pii/S1756464621001778LeadGut microbiotaGut physiologyGut disordersDietary supplement
collection DOAJ
language English
format Article
sources DOAJ
author Leilei Yu
Yaqi Yu
Yue Xiao
Fengwei Tian
Arjan Narbad
Qixiao Zhai
Wei Chen
spellingShingle Leilei Yu
Yaqi Yu
Yue Xiao
Fengwei Tian
Arjan Narbad
Qixiao Zhai
Wei Chen
Lead-induced gut injuries and the dietary protective strategies: A review
Journal of Functional Foods
Lead
Gut microbiota
Gut physiology
Gut disorders
Dietary supplement
author_facet Leilei Yu
Yaqi Yu
Yue Xiao
Fengwei Tian
Arjan Narbad
Qixiao Zhai
Wei Chen
author_sort Leilei Yu
title Lead-induced gut injuries and the dietary protective strategies: A review
title_short Lead-induced gut injuries and the dietary protective strategies: A review
title_full Lead-induced gut injuries and the dietary protective strategies: A review
title_fullStr Lead-induced gut injuries and the dietary protective strategies: A review
title_full_unstemmed Lead-induced gut injuries and the dietary protective strategies: A review
title_sort lead-induced gut injuries and the dietary protective strategies: a review
publisher Elsevier
series Journal of Functional Foods
issn 1756-4646
publishDate 2021-08-01
description Recently, a bidirectional relationship between dietary lead (Pb) exposure and gut changes has been identified. Pb causes gut dysbacteriosis and destroys gut physiological homeostasis, causing a series of oxidative stress, immune-inflammatory reactions and increased permeability of the intestinal barrier. Pb-induced gut dysbiosis and physiological disorders are related to impairments in nutrient absorption, essential element homeostasis, lipid metabolism, and nervous system, which can in turn influence Pb transport and metabolism. Dietary supplements such as probiotics, prebiotics, minerals, and antioxidants could be a potential strategy to alleviate Pb toxicity. They can protect the gut barrier, promote Pb discharge, and regulate oxidative stress and essential metal levels, which likely depend on the gut microbiota. Thus, dietary supplements, especially probiotics and prebiotics, are a new and safe strategy to prevent and alleviate Pb poisoning in the future.
topic Lead
Gut microbiota
Gut physiology
Gut disorders
Dietary supplement
url http://www.sciencedirect.com/science/article/pii/S1756464621001778
work_keys_str_mv AT leileiyu leadinducedgutinjuriesandthedietaryprotectivestrategiesareview
AT yaqiyu leadinducedgutinjuriesandthedietaryprotectivestrategiesareview
AT yuexiao leadinducedgutinjuriesandthedietaryprotectivestrategiesareview
AT fengweitian leadinducedgutinjuriesandthedietaryprotectivestrategiesareview
AT arjannarbad leadinducedgutinjuriesandthedietaryprotectivestrategiesareview
AT qixiaozhai leadinducedgutinjuriesandthedietaryprotectivestrategiesareview
AT weichen leadinducedgutinjuriesandthedietaryprotectivestrategiesareview
_version_ 1721371926774939648

Similar Items